The role of non-protein-coding RNAs in ischemic acute kidney injury
Acute kidney injury (AKI) is a condition characterized by a rapid decline in kidney function within a span of 48 hours. It is influenced by various factors including inflammation, oxidative stress, excessive calcium levels within cells, activation of the renin-angiotensin system, and dysfunction in...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1230742/full |
| _version_ | 1797320890487144448 |
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| author | Fatemeh Sabet Sarvestani Afsoon Afshari Negar Azarpira |
| author_facet | Fatemeh Sabet Sarvestani Afsoon Afshari Negar Azarpira |
| author_sort | Fatemeh Sabet Sarvestani |
| collection | DOAJ |
| description | Acute kidney injury (AKI) is a condition characterized by a rapid decline in kidney function within a span of 48 hours. It is influenced by various factors including inflammation, oxidative stress, excessive calcium levels within cells, activation of the renin-angiotensin system, and dysfunction in microcirculation. Ischemia-reperfusion injury (IRI) is recognized as a major cause of AKI; however, the precise mechanisms behind this process are not yet fully understood and effective treatments are still needed. To enhance the accuracy of diagnosing AKI during its early stages, the utilization of innovative markers is crucial. Numerous studies suggest that certain noncoding RNAs (ncRNAs), such as long noncoding RNAs (lncRNAs), microRNAs (miRNAs), and circular RNAs (circRNAs), play a central role in regulating gene expression and protein synthesis. These ncRNAs are closely associated with the development and recovery of AKI and have been detected in both kidney tissue and bodily fluids. Furthermore, specific ncRNAs may serve as diagnostic markers and potential targets for therapeutic interventions in AKI. This review aims to summarize the functional roles and changes observed in noncoding RNAs during ischemic AKI, as well as explore their therapeutic potential. |
| first_indexed | 2024-03-08T04:49:36Z |
| format | Article |
| id | doaj.art-5d7bfbc125cc422481a355e55f605885 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-08T04:49:36Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-5d7bfbc125cc422481a355e55f6058852024-02-08T05:18:16ZengFrontiers Media S.A.Frontiers in Immunology1664-32242024-02-011510.3389/fimmu.2024.12307421230742The role of non-protein-coding RNAs in ischemic acute kidney injuryFatemeh Sabet Sarvestani0Afsoon Afshari1Negar Azarpira2Shiraz Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, IranShiraz Nephro-Urology Research Center, Shiraz University of Medical Sciences, Shiraz, IranShiraz Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, IranAcute kidney injury (AKI) is a condition characterized by a rapid decline in kidney function within a span of 48 hours. It is influenced by various factors including inflammation, oxidative stress, excessive calcium levels within cells, activation of the renin-angiotensin system, and dysfunction in microcirculation. Ischemia-reperfusion injury (IRI) is recognized as a major cause of AKI; however, the precise mechanisms behind this process are not yet fully understood and effective treatments are still needed. To enhance the accuracy of diagnosing AKI during its early stages, the utilization of innovative markers is crucial. Numerous studies suggest that certain noncoding RNAs (ncRNAs), such as long noncoding RNAs (lncRNAs), microRNAs (miRNAs), and circular RNAs (circRNAs), play a central role in regulating gene expression and protein synthesis. These ncRNAs are closely associated with the development and recovery of AKI and have been detected in both kidney tissue and bodily fluids. Furthermore, specific ncRNAs may serve as diagnostic markers and potential targets for therapeutic interventions in AKI. This review aims to summarize the functional roles and changes observed in noncoding RNAs during ischemic AKI, as well as explore their therapeutic potential.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1230742/fullnoncoding RNAsmiRNAslncRNAscircular RNAsischemiaacute kidney injury |
| spellingShingle | Fatemeh Sabet Sarvestani Afsoon Afshari Negar Azarpira The role of non-protein-coding RNAs in ischemic acute kidney injury Frontiers in Immunology noncoding RNAs miRNAs lncRNAs circular RNAs ischemia acute kidney injury |
| title | The role of non-protein-coding RNAs in ischemic acute kidney injury |
| title_full | The role of non-protein-coding RNAs in ischemic acute kidney injury |
| title_fullStr | The role of non-protein-coding RNAs in ischemic acute kidney injury |
| title_full_unstemmed | The role of non-protein-coding RNAs in ischemic acute kidney injury |
| title_short | The role of non-protein-coding RNAs in ischemic acute kidney injury |
| title_sort | role of non protein coding rnas in ischemic acute kidney injury |
| topic | noncoding RNAs miRNAs lncRNAs circular RNAs ischemia acute kidney injury |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1230742/full |
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