De novo RNA synthesis catalyzed by the Zika Virus RNA polymerase domain
Abstract Mosquito- and tick-borne pathogens including Chikungunya, Dengue, Japanese encephalitis, West Nile, Yellow fever and Zika virus, represent a new economic and public health challenge. In the absence of effective vaccines and specific therapies, only supportive regimens are administrated for...
Main Authors: | Christina Calmels, Michel Ventura, Cindy Aknin, Mathieu Métifiot, Marie-Line Andreola |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2017-06-01
|
Series: | Scientific Reports |
Online Access: | https://doi.org/10.1038/s41598-017-03038-8 |
Similar Items
-
Targeting the Integrated Stress Response Kinase GCN2 to Modulate Retroviral Integration
by: Chloé Torres, et al.
Published: (2021-09-01) -
Discovery of Novel Integrase Inhibitors Acting outside the Active Site Through High-Throughput Screening
by: Cindy Aknin, et al.
Published: (2019-10-01) -
Non-nucleoside inhibitors of Zika virus RNA-dependent RNA polymerase
by: Gharbi-Ayachi, Aïcha, et al.
Published: (2020) -
Crystal structure of Zika virus NS5 RNA-dependent RNA polymerase
by: Andre S. Godoy, et al.
Published: (2017-03-01) -
Sofosbuvir Selects for Drug-Resistant Amino Acid Variants in the Zika Virus RNA-Dependent RNA-Polymerase Complex In Vitro
by: Adele Boccuto, et al.
Published: (2021-03-01)