Phillygenin inhibited M1 macrophage polarization and reduced hepatic stellate cell activation by inhibiting macrophage exosomal miR-125b-5p

Phillygenin inhibited M1 macrophage polarization and reduced hepatic stellate cell activation by inhibiting macrophage exosomal miR-125b-5p

Liver fibrosis (LF) is an important stage in chronic liver disease development, characterized by hepatic stellate cell (HSC) activation and excessive extracellular matrix deposition. Phillygenin (PHI), an active component in the traditional Chinese medicine Forsythiae Fructus with a significant anti...

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Bibliographic Details
Main Authors: Cheng Ma, Cheng Wang, Yafang Zhang, Yanzhi Li, Ke Fu, Lihong Gong, Honglin Zhou, Yunxia Li
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Phillygenin
Liver fibrosis
Hepatic stellate cell activation
Macrophage polarization
Exosomes
MicroRNA
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223000525

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http://www.sciencedirect.com/science/article/pii/S0753332223000525

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