Activation and Inhibition of Human Matrix Metalloproteinase-9 (MMP9) by HOCl, Myeloperoxidase and Chloramines

Activation and Inhibition of Human Matrix Metalloproteinase-9 (MMP9) by HOCl, Myeloperoxidase and Chloramines

Matrix metalloproteinase-9 (MMP9, gelatinase B) plays a key role in the degradation of extracellular-matrix (ECM) proteins in both normal physiology and multiple pathologies, including those linked with inflammation. MMP9 is excreted as an inactive proform (proMMP9) by multiple cells, and particular...

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Bibliographic Details
Main Authors:	Yihe Wang, Christine Y. Chuang, Clare L. Hawkins, Michael J. Davies
Format:	Article
Language:	English
Published:	MDPI AG 2022-08-01
Series:	Antioxidants
Subjects:	matrix metalloproteinase (MMP) extracellular matrix myeloperoxidase hypochlorous acid chloramines tissue inhibitor of matrix metalloproteinase (TIMP)
Online Access:	https://www.mdpi.com/2076-3921/11/8/1616

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