The Cell Autonomous and Non-Cell Autonomous Aspects of Neuronal Vulnerability and Resilience in Amyotrophic Lateral Sclerosis

The Cell Autonomous and Non-Cell Autonomous Aspects of Neuronal Vulnerability and Resilience in Amyotrophic Lateral Sclerosis

Amyotrophic lateral sclerosis (ALS) is defined by the loss of upper motor neurons (MNs) that project from the cerebral cortex to the brain stem and spinal cord and of lower MNs in the brain stem and spinal cord which innervate skeletal muscles, leading to spasticity, muscle atrophy, and paralysis. A...

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Bibliographic Details
Main Authors: Christoph Schweingruber, Eva Hedlund
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Biology
Subjects:
amyotrophic lateral sclerosis
neurodegeneration
neurodegenerative cell metabolism
neuron
Online Access:https://www.mdpi.com/2079-7737/11/8/1191

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