Tumor Infiltrating Lymphocytes Predicting Long-Term Outcomes in HER2-Negative Breast Cancer Patients with Visceral Metastases
Background: Tumor-infiltrating lymphocytes (TILs) were found to be associated with a better clinical outcome in specific subtypes of breast cancer. Aim: To study the association between TILs and the prognosis of Egyptian patients with HER2-negative breast cancer metastatic to the viscera. Methods: T...
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| Format: | Article |
| Language: | English |
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Kasr Al-Ainy Center of Clinical Oncology and Nuclear Medicine
2022-12-01
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| Series: | Research in Oncology |
| Subjects: | |
| Online Access: | https://resoncol.journals.ekb.eg/article_270477_3059978f3da1dc5a0903270e02f2bb30.pdf |
| _version_ | 1797977742553120768 |
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| author | Elia Hakim Amina Mostafa Mohamed Mohamed Mahmoud Sherif Maha El Naggar |
| author_facet | Elia Hakim Amina Mostafa Mohamed Mohamed Mahmoud Sherif Maha El Naggar |
| author_sort | Elia Hakim |
| collection | DOAJ |
| description | Background: Tumor-infiltrating lymphocytes (TILs) were found to be associated with a better clinical outcome in specific subtypes of breast cancer. Aim: To study the association between TILs and the prognosis of Egyptian patients with HER2-negative breast cancer metastatic to the viscera. Methods: This prospective study included 100 patients with HER2-negative metastatic breast cancer. Intratumoral TILs, stromal TILs, and CD4 and CD8 were examined in the pathological specimens and their relationship with survival and response to treatment was studied. Results: At a median follow-up period of 43 months, the median overall survival was 44.7 months (95%CI: 39.2-50.2) and the 5-year overall survival rate was 28%. A high level of CD8+ve TILs was associated with significantly longer overall survival (p < 0.001) and progression-free survival (p=0.043). There was no significant correlation between intratumoral TILs, stromal TILs, or CD4+ve and overall survival. Conclusions: A higher level of CD8+ve TILs is associated with better overall as well as progression-free survival in HER2-negative breast cancer with visceral metastases. |
| first_indexed | 2024-04-11T05:12:58Z |
| format | Article |
| id | doaj.art-5d80652b2c8c40f5837a83e23e289510 |
| institution | Directory Open Access Journal |
| issn | 2357-0687 2357-0695 |
| language | English |
| last_indexed | 2024-04-11T05:12:58Z |
| publishDate | 2022-12-01 |
| publisher | Kasr Al-Ainy Center of Clinical Oncology and Nuclear Medicine |
| record_format | Article |
| series | Research in Oncology |
| spelling | doaj.art-5d80652b2c8c40f5837a83e23e2895102022-12-24T20:13:50ZengKasr Al-Ainy Center of Clinical Oncology and Nuclear MedicineResearch in Oncology2357-06872357-06952022-12-01182455110.21608/resoncol.2022.135734.1166270477Tumor Infiltrating Lymphocytes Predicting Long-Term Outcomes in HER2-Negative Breast Cancer Patients with Visceral MetastasesElia Hakim0Amina Mostafa1Mohamed Mohamed2Mahmoud Sherif3Maha El Naggar4Department of Clinical Oncology, Sohag Cancer Center, Sohag, EgyptDepartment of Clinical Oncology, Assuit University, Assuit, EgyptDepartment of Clinical Oncology, Assuit University, Assuit, EgyptDepartment of Pathology, Assuit University, Assuit, EgyptDepartment of Clinical Oncology, Assuit University, Assuit, EgyptBackground: Tumor-infiltrating lymphocytes (TILs) were found to be associated with a better clinical outcome in specific subtypes of breast cancer. Aim: To study the association between TILs and the prognosis of Egyptian patients with HER2-negative breast cancer metastatic to the viscera. Methods: This prospective study included 100 patients with HER2-negative metastatic breast cancer. Intratumoral TILs, stromal TILs, and CD4 and CD8 were examined in the pathological specimens and their relationship with survival and response to treatment was studied. Results: At a median follow-up period of 43 months, the median overall survival was 44.7 months (95%CI: 39.2-50.2) and the 5-year overall survival rate was 28%. A high level of CD8+ve TILs was associated with significantly longer overall survival (p < 0.001) and progression-free survival (p=0.043). There was no significant correlation between intratumoral TILs, stromal TILs, or CD4+ve and overall survival. Conclusions: A higher level of CD8+ve TILs is associated with better overall as well as progression-free survival in HER2-negative breast cancer with visceral metastases.https://resoncol.journals.ekb.eg/article_270477_3059978f3da1dc5a0903270e02f2bb30.pdfbreast cancercd4cd8her2prognosistumor-infiltrating lymphocytesvisceral metastases |
| spellingShingle | Elia Hakim Amina Mostafa Mohamed Mohamed Mahmoud Sherif Maha El Naggar Tumor Infiltrating Lymphocytes Predicting Long-Term Outcomes in HER2-Negative Breast Cancer Patients with Visceral Metastases Research in Oncology breast cancer cd4 cd8 her2 prognosis tumor-infiltrating lymphocytes visceral metastases |
| title | Tumor Infiltrating Lymphocytes Predicting Long-Term Outcomes in HER2-Negative Breast Cancer Patients with Visceral Metastases |
| title_full | Tumor Infiltrating Lymphocytes Predicting Long-Term Outcomes in HER2-Negative Breast Cancer Patients with Visceral Metastases |
| title_fullStr | Tumor Infiltrating Lymphocytes Predicting Long-Term Outcomes in HER2-Negative Breast Cancer Patients with Visceral Metastases |
| title_full_unstemmed | Tumor Infiltrating Lymphocytes Predicting Long-Term Outcomes in HER2-Negative Breast Cancer Patients with Visceral Metastases |
| title_short | Tumor Infiltrating Lymphocytes Predicting Long-Term Outcomes in HER2-Negative Breast Cancer Patients with Visceral Metastases |
| title_sort | tumor infiltrating lymphocytes predicting long term outcomes in her2 negative breast cancer patients with visceral metastases |
| topic | breast cancer cd4 cd8 her2 prognosis tumor-infiltrating lymphocytes visceral metastases |
| url | https://resoncol.journals.ekb.eg/article_270477_3059978f3da1dc5a0903270e02f2bb30.pdf |
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