Oncogenic <i>KRAS</i>-Induced Feedback Inflammatory Signaling in Pancreatic Cancer: An Overview and New Therapeutic Opportunities

Oncogenic <i>KRAS</i>-Induced Feedback Inflammatory Signaling in Pancreatic Cancer: An Overview and New Therapeutic Opportunities

Pancreatic ductal adenocarcinoma (PDAC) remains highly refractory to treatment. While the <i>KRAS</i> oncogene is present in almost all PDAC cases and accounts for many of the malignant feats of PDAC, targeting KRAS or its canonical, direct effector cascades remains unsuccessful in patie...

Full description

Bibliographic Details
Main Authors:	Sapana Bansod, Paarth B. Dodhiawala, Kian-Huat Lim
Format:	Article
Language:	English
Published:	MDPI AG 2021-10-01
Series:	Cancers
Subjects:	inflammation stroma pancreatic cancer IRAK4 TPL2 TAK1
Online Access:	https://www.mdpi.com/2072-6694/13/21/5481

Similar Items

Deciphering the Role of Innate Immune NF-ĸB Pathway in Pancreatic Cancer
by: Namrata Khurana, et al.
Published: (2020-09-01)

Pancreatic fibrosis, acinar atrophy and chronic inflammation in surgical specimens associated with survival in patients with resectable pancreatic ductal adenocarcinoma
by: Taija Korpela, et al.
Published: (2022-01-01)

The Galectin Family as Molecular Targets: Hopes for Defeating Pancreatic Cancer
by: Noemí Manero-Rupérez, et al.
Published: (2020-03-01)

Pharmacological inhibition of IRAK4 kinase activity does not prevent cachexia in mice with pancreatic cancer
by: Shuxi Qiao, et al.
Published: (2023-07-01)

Innate immune mediator, Interleukin-1 receptor accessory protein (IL1RAP), is expressed and pro-tumorigenic in pancreatic cancer
by: Yang Zhang, et al.
Published: (2022-05-01)

Pancreatic Cancer Chemoresistance to Gemcitabine
by: Manoj Amrutkar, et al.
Published: (2017-11-01)

Tumor Progression Locus 2 Protects against Acute Respiratory Distress Syndrome in Influenza A Virus-Infected Mice
by: Krishna Latha, et al.
Published: (2022-10-01)

Structure-Based Prototype Peptides Targeting the Pseudomonas aeruginosa Type VI Secretion System Effector as a Novel Antibacterial Strategy
by: Xiaopan Gao, et al.
Published: (2017-09-01)

Commonly Used Pancreatic Stellate Cell Cultures Differ Phenotypically and in Their Interactions with Pancreatic Cancer Cells
by: Daniela Lenggenhager, et al.
Published: (2019-01-01)

The Role of Neural Signaling in the Pancreatic Cancer Microenvironment
by: Ryota Takahashi, et al.
Published: (2022-08-01)

Pancreatic Cancer and Its Microenvironment—Recent Advances and Current Controversies
by: Kinga B. Stopa, et al.
Published: (2020-05-01)

Heterogeneity in Pancreatic Cancer Fibroblasts—TGFβ as a Master Regulator?
by: Dale M. Watt, et al.
Published: (2021-10-01)

Apoptosis in the Pancreatic Cancer Tumor Microenvironment—The Double-Edged Sword of Cancer-Associated Fibroblasts
by: Ester Pfeifer, et al.
Published: (2021-07-01)

Phospho-Ser<sup>784</sup>-VCP Drives Resistance of Pancreatic Ductal Adenocarcinoma to Genotoxic Chemotherapies and Predicts the Chemo-Sensitizing Effect of VCP Inhibitor
by: Faliang Wang, et al.
Published: (2021-10-01)

Mechanisms of resistance to chemotherapeutic and antiangiogenic drugs as novel targets for pancreatic cancer therapy
by: Anna eTamburrino, et al.
Published: (2013-04-01)

Tumor Stroma Area and Other Prognostic Factors in Pancreatic Ductal Adenocarcinoma Patients Submitted to Surgery
by: Maria João Amaral, et al.
Published: (2023-02-01)

The hepatic microenvironment essentially determines tumor cell dormancy and metastatic outgrowth of pancreatic ductal adenocarcinoma
by: Lennart Lenk, et al.
Published: (2018-01-01)

Unravelling the Impact of the Genetic Variant rs1042058 within the TPL2 Risk Gene Locus on Molecular and Clinical Disease Course Patients with Inflammatory Bowel Disease
by: Yasser Morsy, et al.
Published: (2021-12-01)

The roles of TPL in hematological malignancies
by: Tingyun Xu, et al.
Published: (2023-12-01)

Pricing decision research for TPL considering different logistics service level influencing the market demand
by: Wei Li, et al.
Published: (2013-03-01)

<i>GmFULc</i> Is Induced by Short Days in Soybean and May Accelerate Flowering in Transgenic <i>Arabidopsis thaliana</i>
by: Jingzhe Sun, et al.
Published: (2021-09-01)

Rethinking the Roles of Cancer-Associated Fibroblasts in Pancreatic CancerSummary
by: Ralph Francescone, et al.
Published: (2024-01-01)

Dissecting FGF Signalling to Target Cellular Crosstalk in Pancreatic Cancer
by: Edward P. Carter, et al.
Published: (2021-04-01)

Hsp70 modulates immune response in pancreatic cancer through dendritic cells
by: Bhuwan Giri, et al.
Published: (2021-01-01)

Soluble Compounds Released by Hypoxic Stroma Confer Invasive Properties to Pancreatic Ductal Adenocarcinoma
by: Dajia Liu, et al.
Published: (2020-10-01)

Immune features of the peritumoral stroma in pancreatic ductal adenocarcinoma
by: Azaz Ahmed, et al.
Published: (2022-09-01)

Photodynamic Therapy for Pancreatic Ductal Adenocarcinoma
by: Vida Karimnia, et al.
Published: (2021-08-01)

The Immune Microenvironment in Pancreatic Cancer
by: Magdalena Huber, et al.
Published: (2020-10-01)

Targeting the Stromal Pro-Tumoral Hyaluronan-CD44 Pathway in Pancreatic Cancer
by: Tomas Koltai, et al.
Published: (2021-04-01)

The Immune Landscape of Human Pancreatic Ductal Carcinoma: Key Players, Clinical Implications, and Challenges
by: Marie Muller, et al.
Published: (2022-02-01)

Exploitation and Verification of a Stroma- and Metastasis-Associated Risk Prognostic Signature in Pancreatic Adenocarcinoma
by: Jia-Hao Zheng, et al.
Published: (2022-10-01)

IMPLIKASI HUKUM ASAS PRADUGA BERSALAH YANG DIGUNAKAN WARTAWAN DALAM PEMBERITAAN PERKARA PIDANA
by: Hanugrah Titi Habsari
Published: (2017-08-01)

Emerging Therapies and Future Directions in Targeting the Tumor Stroma and Immune System in the Treatment of Pancreatic Adenocarcinoma
by: Daniel H. Ahn, et al.
Published: (2018-06-01)

Targeting Mutant <i>KRAS</i> in Pancreatic Cancer: Futile or Promising?
by: Friederike Inga Nollmann, et al.
Published: (2020-08-01)

Klasifikasi kata kerja tak ergatif dan kata kerja tak akusatif dalam Bahasa Melayu: Agentiviti dan penamat
by: Maslida Yusof, et al.
Published: (2022-11-01)

Myofibroblastic CAF Density, Not Activated Stroma Index, Indicates Prognosis after Neoadjuvant Therapy of Pancreatic Carcinoma
by: Ulrike Heger, et al.
Published: (2022-08-01)

Morphological Heterogeneity in Pancreatic Cancer Reflects Structural and Functional Divergence
by: Petra Sántha, et al.
Published: (2021-02-01)

Differential Effects of Dietary Macronutrients on the Development of Oncogenic KRAS-Mediated Pancreatic Ductal Adenocarcinoma
by: Liang Zhu, et al.
Published: (2022-05-01)

Development of primary human pancreatic cancer organoids, matched stromal and immune cells and 3D tumor microenvironment models
by: Susan Tsai, et al.
Published: (2018-03-01)

Genomic Aberrations Generate Fusion Gene FOXK2::TP63 and Activate NFKB1 in Cutaneous T-Cell Lymphoma
by: Stefan Nagel, et al.
Published: (2022-08-01)