Assessing long-distance RNA sequence connectivity via RNA-templated DNA–DNA ligation

Many RNAs, including pre-mRNAs and long non-coding RNAs, can be thousands of nucleotides long and undergo complex post-transcriptional processing. Multiple sites of alternative splicing within a single gene exponentially increase the number of possible spliced isoforms, with most human genes current...

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Bibliographic Details
Main Authors: Christian K Roy, Sara Olson, Brenton R Graveley, Phillip D Zamore, Melissa J Moore
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-04-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/03700