Genetic peculiarities associated with interleukins exchange in patients with hepatocellular carcinoma resulting from viral hepatitis C
The mechanisms of hepatocellular carcinoma (HCC) formation still remain poorly understood. There are certain genetic features associated with the development of HCC. Objectives. To establish genetic peculiarities connected with interleukin stimulation and associated with the development of hepatoc...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Vitebsk State Order of Peoples’ Friendship Medical University
2022-06-01
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| Series: | Вестник Витебского государственного медицинского университета |
| Subjects: | |
| Online Access: | https://vestnik.vsmu.by/downloads/2022/3/2022_21_3_27-34.pdf |
| Summary: | The mechanisms of hepatocellular carcinoma (HCC) formation still remain poorly understood. There are certain genetic features associated with the development of HCC.
Objectives. To establish genetic peculiarities connected with interleukin stimulation and associated with the development of hepatocellular carcinoma in patients with viral hepatitis C (HCV).
Material and methods. Genetic features of patients with liver diseases were determined by comparative analysis of gene expression in liver tissues based on the sequencing results available in open databases in 72 patients with hepatocellular carcinoma due to hepatitis C and 24 patients without any liver damage.
Results. In patients with HCC-HCV, there is an increased expression of 4330 (7.93%) genes and a reduced expression of 693 (1.27%) genes compared with healthy individuals. Among the signaling pathways associated with the activity of interleukins (IL), as well as in patients with HCC-HCV, the largest number of genes is involved in the signaling pathway of interleukin-11, IL-1, IL-4 and IL-13, IL-10.
Conclusions. An increased production of pro-inflammatory cytokines IL-1, 4, 6, 8, 13, that predominantly provide for overexpression of genes associated with the JAK/STAT signaling pathway has been established. At the same time, the production of anti-inflammatory cytokines, such as IL-10, 11, ensuring cell growth and proliferation, angiogenesis, and regulation of apoptosis processes is observed. |
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| ISSN: | 1607-9906 2312-4156 |