Genetic peculiarities associated with interleukins exchange in patients with hepatocellular carcinoma resulting from viral hepatitis C
The mechanisms of hepatocellular carcinoma (HCC) formation still remain poorly understood. There are certain genetic features associated with the development of HCC. Objectives. To establish genetic peculiarities connected with interleukin stimulation and associated with the development of hepatoc...
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| Format: | Article |
| Language: | English |
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Vitebsk State Order of Peoples’ Friendship Medical University
2022-06-01
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| Series: | Вестник Витебского государственного медицинского университета |
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| Online Access: | https://vestnik.vsmu.by/downloads/2022/3/2022_21_3_27-34.pdf |
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| author | H.I. Yupatau V.A. Pryshchepenka Z.G. Yupatava O.A. Pryshchepenka |
| author_facet | H.I. Yupatau V.A. Pryshchepenka Z.G. Yupatava O.A. Pryshchepenka |
| author_sort | H.I. Yupatau |
| collection | DOAJ |
| description | The mechanisms of hepatocellular carcinoma (HCC) formation still remain poorly understood. There are certain genetic features associated with the development of HCC.
Objectives. To establish genetic peculiarities connected with interleukin stimulation and associated with the development of hepatocellular carcinoma in patients with viral hepatitis C (HCV).
Material and methods. Genetic features of patients with liver diseases were determined by comparative analysis of gene expression in liver tissues based on the sequencing results available in open databases in 72 patients with hepatocellular carcinoma due to hepatitis C and 24 patients without any liver damage.
Results. In patients with HCC-HCV, there is an increased expression of 4330 (7.93%) genes and a reduced expression of 693 (1.27%) genes compared with healthy individuals. Among the signaling pathways associated with the activity of interleukins (IL), as well as in patients with HCC-HCV, the largest number of genes is involved in the signaling pathway of interleukin-11, IL-1, IL-4 and IL-13, IL-10.
Conclusions. An increased production of pro-inflammatory cytokines IL-1, 4, 6, 8, 13, that predominantly provide for overexpression of genes associated with the JAK/STAT signaling pathway has been established. At the same time, the production of anti-inflammatory cytokines, such as IL-10, 11, ensuring cell growth and proliferation, angiogenesis, and regulation of apoptosis processes is observed. |
| first_indexed | 2024-04-13T16:47:30Z |
| format | Article |
| id | doaj.art-5d868f2e9c4e45188a1c18f0dacfa209 |
| institution | Directory Open Access Journal |
| issn | 1607-9906 2312-4156 |
| language | English |
| last_indexed | 2024-04-13T16:47:30Z |
| publishDate | 2022-06-01 |
| publisher | Vitebsk State Order of Peoples’ Friendship Medical University |
| record_format | Article |
| series | Вестник Витебского государственного медицинского университета |
| spelling | doaj.art-5d868f2e9c4e45188a1c18f0dacfa2092022-12-22T02:39:02ZengVitebsk State Order of Peoples’ Friendship Medical UniversityВестник Витебского государственного медицинского университета1607-99062312-41562022-06-012132734https://doi.org/10.22263/2312-4156.2022.3.27Genetic peculiarities associated with interleukins exchange in patients with hepatocellular carcinoma resulting from viral hepatitis CH.I. Yupatau0V.A. Pryshchepenka1Z.G. Yupatava2O.A. Pryshchepenka3Vitebsk State Order of Peoples’ Friendship Medical University, Vitebsk, Republic of BelarusVitebsk State Order of Peoples’ Friendship Medical University, Vitebsk, Republic of BelarusThe 6th City Clinical Hospital, Minsk, Republic of BelarusVitebsk State Order of Peoples’ Friendship Medical University, Vitebsk, Republic of BelarusThe mechanisms of hepatocellular carcinoma (HCC) formation still remain poorly understood. There are certain genetic features associated with the development of HCC. Objectives. To establish genetic peculiarities connected with interleukin stimulation and associated with the development of hepatocellular carcinoma in patients with viral hepatitis C (HCV). Material and methods. Genetic features of patients with liver diseases were determined by comparative analysis of gene expression in liver tissues based on the sequencing results available in open databases in 72 patients with hepatocellular carcinoma due to hepatitis C and 24 patients without any liver damage. Results. In patients with HCC-HCV, there is an increased expression of 4330 (7.93%) genes and a reduced expression of 693 (1.27%) genes compared with healthy individuals. Among the signaling pathways associated with the activity of interleukins (IL), as well as in patients with HCC-HCV, the largest number of genes is involved in the signaling pathway of interleukin-11, IL-1, IL-4 and IL-13, IL-10. Conclusions. An increased production of pro-inflammatory cytokines IL-1, 4, 6, 8, 13, that predominantly provide for overexpression of genes associated with the JAK/STAT signaling pathway has been established. At the same time, the production of anti-inflammatory cytokines, such as IL-10, 11, ensuring cell growth and proliferation, angiogenesis, and regulation of apoptosis processes is observed.https://vestnik.vsmu.by/downloads/2022/3/2022_21_3_27-34.pdfhepatocellular carcinomaviral hepatitis cliver cancerinterleukinsignaling pathwaysequencing |
| spellingShingle | H.I. Yupatau V.A. Pryshchepenka Z.G. Yupatava O.A. Pryshchepenka Genetic peculiarities associated with interleukins exchange in patients with hepatocellular carcinoma resulting from viral hepatitis C Вестник Витебского государственного медицинского университета hepatocellular carcinoma viral hepatitis c liver cancer interleukin signaling pathway sequencing |
| title | Genetic peculiarities associated with interleukins exchange in patients with hepatocellular carcinoma resulting from viral hepatitis C |
| title_full | Genetic peculiarities associated with interleukins exchange in patients with hepatocellular carcinoma resulting from viral hepatitis C |
| title_fullStr | Genetic peculiarities associated with interleukins exchange in patients with hepatocellular carcinoma resulting from viral hepatitis C |
| title_full_unstemmed | Genetic peculiarities associated with interleukins exchange in patients with hepatocellular carcinoma resulting from viral hepatitis C |
| title_short | Genetic peculiarities associated with interleukins exchange in patients with hepatocellular carcinoma resulting from viral hepatitis C |
| title_sort | genetic peculiarities associated with interleukins exchange in patients with hepatocellular carcinoma resulting from viral hepatitis c |
| topic | hepatocellular carcinoma viral hepatitis c liver cancer interleukin signaling pathway sequencing |
| url | https://vestnik.vsmu.by/downloads/2022/3/2022_21_3_27-34.pdf |
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