Review of Mechanisms and Treatment of Cancer-Induced Cardiac Cachexia
Cancer cachexia is a multifactorial, paraneoplastic syndrome that impacts roughly half of all cancer patients. It can negatively impact patient quality of life and prognosis by causing physical impairment, reducing chemotherapy tolerance, and precluding them as surgical candidates. While there is su...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/11/6/1040 |
| _version_ | 1797472370989989888 |
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| author | Vignesh Vudatha Teja Devarakonda Christopher Liu Devon C. Freudenberger Andrea N. Riner Kelly M. Herremans Jose G. Trevino |
| author_facet | Vignesh Vudatha Teja Devarakonda Christopher Liu Devon C. Freudenberger Andrea N. Riner Kelly M. Herremans Jose G. Trevino |
| author_sort | Vignesh Vudatha |
| collection | DOAJ |
| description | Cancer cachexia is a multifactorial, paraneoplastic syndrome that impacts roughly half of all cancer patients. It can negatively impact patient quality of life and prognosis by causing physical impairment, reducing chemotherapy tolerance, and precluding them as surgical candidates. While there is substantial research on cancer-induced skeletal muscle cachexia, there are comparatively fewer studies and therapies regarding cardiac cachexia in the setting of malignancy. A literature review was performed using the PubMed database to identify original articles pertaining to cancer-induced cardiac cachexia, including its mechanisms and potential therapeutic modalities. Seventy studies were identified by two independent reviewers based on inclusion and exclusion criteria. While there are multiple studies addressing the pathophysiology of cardiac-induced cancer cachexia, there are no studies evaluating therapeutic options in the clinical setting. Many treatment modalities including nutrition, heart failure medication, cancer drugs, exercise, and gene therapy have been explored in in vitro and mice models with varying degrees of success. While these may be beneficial in cancer patients, further prospective studies specifically focusing on the assessment and treatment of the cardiac component of cachexia are needed. |
| first_indexed | 2024-03-09T20:00:53Z |
| format | Article |
| id | doaj.art-5d8770d9ed5e407b8d6adb3b7cf3b6a0 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-09T20:00:53Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-5d8770d9ed5e407b8d6adb3b7cf3b6a02023-11-24T00:45:01ZengMDPI AGCells2073-44092022-03-01116104010.3390/cells11061040Review of Mechanisms and Treatment of Cancer-Induced Cardiac CachexiaVignesh Vudatha0Teja Devarakonda1Christopher Liu2Devon C. Freudenberger3Andrea N. Riner4Kelly M. Herremans5Jose G. Trevino6Department of Surgery, Virginia Commonwealth University School of Medicine, 1200 E Broad St., P.O. Box 980011, Richmond, VA 23219, USADepartment of Surgery, Virginia Commonwealth University School of Medicine, 1200 E Broad St., P.O. Box 980011, Richmond, VA 23219, USADepartment of Surgery, Virginia Commonwealth University School of Medicine, 1200 E Broad St., P.O. Box 980011, Richmond, VA 23219, USADepartment of Surgery, Virginia Commonwealth University School of Medicine, 1200 E Broad St., P.O. Box 980011, Richmond, VA 23219, USADepartment of Surgery, University of Florida College of Medicine, 1600 SW Archer Rd, P.O. Box 100287, Gainesville, FL 32610, USADepartment of Surgery, University of Florida College of Medicine, 1600 SW Archer Rd, P.O. Box 100287, Gainesville, FL 32610, USADepartment of Surgery, Virginia Commonwealth University School of Medicine, 1200 E Broad St., P.O. Box 980011, Richmond, VA 23219, USACancer cachexia is a multifactorial, paraneoplastic syndrome that impacts roughly half of all cancer patients. It can negatively impact patient quality of life and prognosis by causing physical impairment, reducing chemotherapy tolerance, and precluding them as surgical candidates. While there is substantial research on cancer-induced skeletal muscle cachexia, there are comparatively fewer studies and therapies regarding cardiac cachexia in the setting of malignancy. A literature review was performed using the PubMed database to identify original articles pertaining to cancer-induced cardiac cachexia, including its mechanisms and potential therapeutic modalities. Seventy studies were identified by two independent reviewers based on inclusion and exclusion criteria. While there are multiple studies addressing the pathophysiology of cardiac-induced cancer cachexia, there are no studies evaluating therapeutic options in the clinical setting. Many treatment modalities including nutrition, heart failure medication, cancer drugs, exercise, and gene therapy have been explored in in vitro and mice models with varying degrees of success. While these may be beneficial in cancer patients, further prospective studies specifically focusing on the assessment and treatment of the cardiac component of cachexia are needed.https://www.mdpi.com/2073-4409/11/6/1040cancercardiac cachexiareactive oxygen speciesTNFα |
| spellingShingle | Vignesh Vudatha Teja Devarakonda Christopher Liu Devon C. Freudenberger Andrea N. Riner Kelly M. Herremans Jose G. Trevino Review of Mechanisms and Treatment of Cancer-Induced Cardiac Cachexia Cells cancer cardiac cachexia reactive oxygen species TNFα |
| title | Review of Mechanisms and Treatment of Cancer-Induced Cardiac Cachexia |
| title_full | Review of Mechanisms and Treatment of Cancer-Induced Cardiac Cachexia |
| title_fullStr | Review of Mechanisms and Treatment of Cancer-Induced Cardiac Cachexia |
| title_full_unstemmed | Review of Mechanisms and Treatment of Cancer-Induced Cardiac Cachexia |
| title_short | Review of Mechanisms and Treatment of Cancer-Induced Cardiac Cachexia |
| title_sort | review of mechanisms and treatment of cancer induced cardiac cachexia |
| topic | cancer cardiac cachexia reactive oxygen species TNFα |
| url | https://www.mdpi.com/2073-4409/11/6/1040 |
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