Forward Precision Medicine: Micelles for Active Targeting Driven by Peptides
Precision medicine is based on innovative administration methods of active principles. Drug delivery on tissue of interest allows improving the therapeutic index and reducing the side effects. Active targeting by means of drug-encapsulated micelles decorated with targeting bioactive moieties represe...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/26/13/4049 |
| _version_ | 1797527924072513536 |
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| author | Filippo Prencipe Carlo Diaferia Filomena Rossi Luisa Ronga Diego Tesauro |
| author_facet | Filippo Prencipe Carlo Diaferia Filomena Rossi Luisa Ronga Diego Tesauro |
| author_sort | Filippo Prencipe |
| collection | DOAJ |
| description | Precision medicine is based on innovative administration methods of active principles. Drug delivery on tissue of interest allows improving the therapeutic index and reducing the side effects. Active targeting by means of drug-encapsulated micelles decorated with targeting bioactive moieties represents a new frontier. Between the bioactive moieties, peptides, for their versatility, easy synthesis and immunogenicity, can be selected to direct a drug toward a considerable number of molecular targets overexpressed on both cancer vasculature and cancer cells. Moreover, short peptide sequences can facilitate cellular intake. This review focuses on micelles achieved by self-assembling or mixing peptide-grafted surfactants or peptide-decorated amphiphilic copolymers. Nanovectors loaded with hydrophobic or hydrophilic cytotoxic drugs or with gene silence sequences and externally functionalized with natural or synthetic peptides are described based on their formulation and in vitro and in vivo behaviors. |
| first_indexed | 2024-03-10T09:50:45Z |
| format | Article |
| id | doaj.art-5d88344a0ff941208e845db3091fc60e |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T09:50:45Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-5d88344a0ff941208e845db3091fc60e2023-11-22T02:47:19ZengMDPI AGMolecules1420-30492021-07-012613404910.3390/molecules26134049Forward Precision Medicine: Micelles for Active Targeting Driven by PeptidesFilippo Prencipe0Carlo Diaferia1Filomena Rossi2Luisa Ronga3Diego Tesauro4Institute of Crystallography (IC) CNR, Via Amendola 122/o, 70126 Bari, ItalyDepartment of Pharmacy and Interuniversity Research Centre on Bioactive Peptides (CIRPeB), University of Naples “Federico II”, via Mezzocannone 16, 80134 Naples, ItalyDepartment of Pharmacy and Interuniversity Research Centre on Bioactive Peptides (CIRPeB), University of Naples “Federico II”, via Mezzocannone 16, 80134 Naples, ItalyInstitut des Sciences Analytiques et de Physico-Chimie Pour l’Environnement et les Matériaux, Université de Pau et des Pays de l’Adour, E2S UPPA, CNRS, IPREM, 64053 Pau, FranceDepartment of Pharmacy and Interuniversity Research Centre on Bioactive Peptides (CIRPeB), University of Naples “Federico II”, via Mezzocannone 16, 80134 Naples, ItalyPrecision medicine is based on innovative administration methods of active principles. Drug delivery on tissue of interest allows improving the therapeutic index and reducing the side effects. Active targeting by means of drug-encapsulated micelles decorated with targeting bioactive moieties represents a new frontier. Between the bioactive moieties, peptides, for their versatility, easy synthesis and immunogenicity, can be selected to direct a drug toward a considerable number of molecular targets overexpressed on both cancer vasculature and cancer cells. Moreover, short peptide sequences can facilitate cellular intake. This review focuses on micelles achieved by self-assembling or mixing peptide-grafted surfactants or peptide-decorated amphiphilic copolymers. Nanovectors loaded with hydrophobic or hydrophilic cytotoxic drugs or with gene silence sequences and externally functionalized with natural or synthetic peptides are described based on their formulation and in vitro and in vivo behaviors.https://www.mdpi.com/1420-3049/26/13/4049micellespeptide targetingdrug deliveryprecision medicinenanomedicine |
| spellingShingle | Filippo Prencipe Carlo Diaferia Filomena Rossi Luisa Ronga Diego Tesauro Forward Precision Medicine: Micelles for Active Targeting Driven by Peptides Molecules micelles peptide targeting drug delivery precision medicine nanomedicine |
| title | Forward Precision Medicine: Micelles for Active Targeting Driven by Peptides |
| title_full | Forward Precision Medicine: Micelles for Active Targeting Driven by Peptides |
| title_fullStr | Forward Precision Medicine: Micelles for Active Targeting Driven by Peptides |
| title_full_unstemmed | Forward Precision Medicine: Micelles for Active Targeting Driven by Peptides |
| title_short | Forward Precision Medicine: Micelles for Active Targeting Driven by Peptides |
| title_sort | forward precision medicine micelles for active targeting driven by peptides |
| topic | micelles peptide targeting drug delivery precision medicine nanomedicine |
| url | https://www.mdpi.com/1420-3049/26/13/4049 |
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