Inhibitory effects of saeu‐jeot extract on NLRP3 inflammasome activation and radiation‐induced micronucleus formation
Abstract Purpose Saeu‐jeot, or shrimp paste, is a traditional Korean high‐salt fermented seafood. This study elucidated the effects of saeu‐jeot extract (SJE) on NLRP3 inflammasome activation and radiation‐induced micronucleus formation. Method We treated lipopolysaccharide‐primed mouse bone marrow‐...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-06-01
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| Series: | Food Science & Nutrition |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/fsn3.2808 |
| _version_ | 1797986234542325760 |
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| author | Lan Li Hee‐Sun Kim Sung‐Won Kwon Min‐Jae Lee |
| author_facet | Lan Li Hee‐Sun Kim Sung‐Won Kwon Min‐Jae Lee |
| author_sort | Lan Li |
| collection | DOAJ |
| description | Abstract Purpose Saeu‐jeot, or shrimp paste, is a traditional Korean high‐salt fermented seafood. This study elucidated the effects of saeu‐jeot extract (SJE) on NLRP3 inflammasome activation and radiation‐induced micronucleus formation. Method We treated lipopolysaccharide‐primed mouse bone marrow‐derived macrophages with the NLRP3 inflammasome activators ATP and nigericin. We also analyzed the acute effects of ionizing radiation on micronucleated polychromatic erythrocytes (MnPCEs) in whole‐body gamma‐irradiated male BALB/c and C57BL/6 mice after oral administration of SJE. Results SJE significantly inhibited NLRP3 inflammasome activation, reducing IL‐1β secretion in vitro. In addition, the frequency of MnPCEs was significantly lower in SJE‐treated mice. Conclusions SJE has anti‐inflammatory effects and reduces radiation‐induced chromosome damage. Advance in knowledge: There are no reports concerning the effects of SJE on NLRP3 inflammasome activation or radioprotection. This experiment showed the radioprotective effects of saeu‐jeot. |
| first_indexed | 2024-04-11T07:30:43Z |
| format | Article |
| id | doaj.art-5d89a7028ba040bebf12a80859059695 |
| institution | Directory Open Access Journal |
| issn | 2048-7177 |
| language | English |
| last_indexed | 2024-04-11T07:30:43Z |
| publishDate | 2022-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Food Science & Nutrition |
| spelling | doaj.art-5d89a7028ba040bebf12a808590596952022-12-22T04:36:53ZengWileyFood Science & Nutrition2048-71772022-06-011061921192710.1002/fsn3.2808Inhibitory effects of saeu‐jeot extract on NLRP3 inflammasome activation and radiation‐induced micronucleus formationLan Li0Hee‐Sun Kim1Sung‐Won Kwon2Min‐Jae Lee3School of Public Health and Management Wenzhou Medical University Wenzhou ChinaRadiation Health Research Institute Korea Hydro and Nuclear Power Co., Ltd. Seoul South KoreaCHA Bundang Medical Center CHA University Seongnam‐si South KoreaDepartment of Laboratory Animal Medicine College of Veterinary Medicine Kangwon National University Chuncheon South KoreaAbstract Purpose Saeu‐jeot, or shrimp paste, is a traditional Korean high‐salt fermented seafood. This study elucidated the effects of saeu‐jeot extract (SJE) on NLRP3 inflammasome activation and radiation‐induced micronucleus formation. Method We treated lipopolysaccharide‐primed mouse bone marrow‐derived macrophages with the NLRP3 inflammasome activators ATP and nigericin. We also analyzed the acute effects of ionizing radiation on micronucleated polychromatic erythrocytes (MnPCEs) in whole‐body gamma‐irradiated male BALB/c and C57BL/6 mice after oral administration of SJE. Results SJE significantly inhibited NLRP3 inflammasome activation, reducing IL‐1β secretion in vitro. In addition, the frequency of MnPCEs was significantly lower in SJE‐treated mice. Conclusions SJE has anti‐inflammatory effects and reduces radiation‐induced chromosome damage. Advance in knowledge: There are no reports concerning the effects of SJE on NLRP3 inflammasome activation or radioprotection. This experiment showed the radioprotective effects of saeu‐jeot.https://doi.org/10.1002/fsn3.2808inflammasomemicronucleiNLRP3radiationsaeu‐jeot |
| spellingShingle | Lan Li Hee‐Sun Kim Sung‐Won Kwon Min‐Jae Lee Inhibitory effects of saeu‐jeot extract on NLRP3 inflammasome activation and radiation‐induced micronucleus formation Food Science & Nutrition inflammasome micronuclei NLRP3 radiation saeu‐jeot |
| title | Inhibitory effects of saeu‐jeot extract on NLRP3 inflammasome activation and radiation‐induced micronucleus formation |
| title_full | Inhibitory effects of saeu‐jeot extract on NLRP3 inflammasome activation and radiation‐induced micronucleus formation |
| title_fullStr | Inhibitory effects of saeu‐jeot extract on NLRP3 inflammasome activation and radiation‐induced micronucleus formation |
| title_full_unstemmed | Inhibitory effects of saeu‐jeot extract on NLRP3 inflammasome activation and radiation‐induced micronucleus formation |
| title_short | Inhibitory effects of saeu‐jeot extract on NLRP3 inflammasome activation and radiation‐induced micronucleus formation |
| title_sort | inhibitory effects of saeu jeot extract on nlrp3 inflammasome activation and radiation induced micronucleus formation |
| topic | inflammasome micronuclei NLRP3 radiation saeu‐jeot |
| url | https://doi.org/10.1002/fsn3.2808 |
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