KDM5C Represses FASN-Mediated Lipid Metabolism to Exert Tumor Suppressor Activity in Intrahepatic Cholangiocarcinoma

KDM5C Represses FASN-Mediated Lipid Metabolism to Exert Tumor Suppressor Activity in Intrahepatic Cholangiocarcinoma

Background: KDM5C is a histone H3K4-specific demethylase, which has multiple biological functions during development and disease. However, the role of KDM5C in intrahepatic cholangiocarcinoma (ICC) remains unknown.Methods: Expression levels of KDM5C in ICC patients were determined by qRT-PCR, wester...

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Bibliographic Details
Main Authors: Bo Zhang, Bing-hai Zhou, Min Xiao, Hui Li, Lei Guo, Meng-xi Wang, Shan-he Yu, Qing-hai Ye
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Oncology
Subjects:
KDM5C
FASN
cell proliferation
cell invasion
intrahepatic cholangiocarcinoma
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.01025/full

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