Genetic predictors of obstetric complications: intergenetic association
The goal of the research is to analyze the intergenic interaction of the marker-genes of thrombophilia, the disruption of gomocystein cycle and blood pressure control. Two groups of women have been included in the investigation. The under study group consists of 197 women with eclampcy and pregnancy...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Peoples’ Friendship University of Russia (RUDN University)
2012-12-01
|
| Series: | RUDN Journal of Medicine |
| Subjects: | |
| Online Access: | http://journals.rudn.ru/medicine/article/view/3667 |
| _version_ | 1818066198062956544 |
|---|---|
| author | T B Tretyakova N V Bashmakova N S Demchenko |
| author_facet | T B Tretyakova N V Bashmakova N S Demchenko |
| author_sort | T B Tretyakova |
| collection | DOAJ |
| description | The goal of the research is to analyze the intergenic interaction of the marker-genes of thrombophilia, the disruption of gomocystein cycle and blood pressure control. Two groups of women have been included in the investigation. The under study group consists of 197 women with eclampcy and pregnancy miscarriage in anamnesis. The comparison group consists of 228 women with normal obstetric anamnesis. The molecular-genetic analysis of 21 allelic polymorphisms of MTHFR, MTR, MTRR, FGB, F2, F5, F7, F13, ITGA2, ITGB3, PAI-1, ADD1, AGT, AGTR1, AGTR2, CYP, GNB, NOS3 genes has been carried out. Statistically significant differences haven’t been revealed in the univariate analysis of the alternative genotypes rate between groups. However, we have found out that the frequency of combined genotypes (AGT 704CC, GNB 825CT, NOS3 894GT, MTR 2756AG) in group with eclampcy and pregnancy miscarriage in anamnesis is statistically higher. |
| first_indexed | 2024-12-10T15:03:58Z |
| format | Article |
| id | doaj.art-5d8c48796952466783598af2b04b82f3 |
| institution | Directory Open Access Journal |
| issn | 2313-0245 2313-0261 |
| language | English |
| last_indexed | 2024-12-10T15:03:58Z |
| publishDate | 2012-12-01 |
| publisher | Peoples’ Friendship University of Russia (RUDN University) |
| record_format | Article |
| series | RUDN Journal of Medicine |
| spelling | doaj.art-5d8c48796952466783598af2b04b82f32022-12-22T01:44:06ZengPeoples’ Friendship University of Russia (RUDN University)RUDN Journal of Medicine2313-02452313-02612012-12-010S623283667Genetic predictors of obstetric complications: intergenetic associationT B Tretyakova0N V Bashmakova1N S Demchenko2ФГБУ «Научно-исследовательский институт охраны материнства и младенчества» Минздравсоцразвития РоссииФГБУ «Научно-исследовательский институт охраны материнства и младенчества» Минздравсоцразвития РоссииФГБУ «Научно-исследовательский институт охраны материнства и младенчества» Минздравсоцразвития РоссииThe goal of the research is to analyze the intergenic interaction of the marker-genes of thrombophilia, the disruption of gomocystein cycle and blood pressure control. Two groups of women have been included in the investigation. The under study group consists of 197 women with eclampcy and pregnancy miscarriage in anamnesis. The comparison group consists of 228 women with normal obstetric anamnesis. The molecular-genetic analysis of 21 allelic polymorphisms of MTHFR, MTR, MTRR, FGB, F2, F5, F7, F13, ITGA2, ITGB3, PAI-1, ADD1, AGT, AGTR1, AGTR2, CYP, GNB, NOS3 genes has been carried out. Statistically significant differences haven’t been revealed in the univariate analysis of the alternative genotypes rate between groups. However, we have found out that the frequency of combined genotypes (AGT 704CC, GNB 825CT, NOS3 894GT, MTR 2756AG) in group with eclampcy and pregnancy miscarriage in anamnesis is statistically higher.http://journals.rudn.ru/medicine/article/view/3667полиморфизм геновкомбинированный генотип |
| spellingShingle | T B Tretyakova N V Bashmakova N S Demchenko Genetic predictors of obstetric complications: intergenetic association RUDN Journal of Medicine полиморфизм генов комбинированный генотип |
| title | Genetic predictors of obstetric complications: intergenetic association |
| title_full | Genetic predictors of obstetric complications: intergenetic association |
| title_fullStr | Genetic predictors of obstetric complications: intergenetic association |
| title_full_unstemmed | Genetic predictors of obstetric complications: intergenetic association |
| title_short | Genetic predictors of obstetric complications: intergenetic association |
| title_sort | genetic predictors of obstetric complications intergenetic association |
| topic | полиморфизм генов комбинированный генотип |
| url | http://journals.rudn.ru/medicine/article/view/3667 |
| work_keys_str_mv | AT tbtretyakova geneticpredictorsofobstetriccomplicationsintergeneticassociation AT nvbashmakova geneticpredictorsofobstetriccomplicationsintergeneticassociation AT nsdemchenko geneticpredictorsofobstetriccomplicationsintergeneticassociation |