Phages against Pathogenic Bacterial Biofilms and Biofilm-Based Infections: A Review
Bacterial biofilms formed by pathogens are known to be hundreds of times more resistant to antimicrobial agents than planktonic cells, making it extremely difficult to cure biofilm-based infections despite the use of antibiotics, which poses a serious threat to human health. Therefore, there is an u...
| Päätekijät: | , , , , |
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| Aineistotyyppi: | Artikkeli |
| Kieli: | English |
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MDPI AG
2022-02-01
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| Sarja: | Pharmaceutics |
| Aiheet: | |
| Linkit: | https://www.mdpi.com/1999-4923/14/2/427 |
| _version_ | 1827653220211621888 |
|---|---|
| author | Siyu Liu Hongyun Lu Shengliang Zhang Ying Shi Qihe Chen |
| author_facet | Siyu Liu Hongyun Lu Shengliang Zhang Ying Shi Qihe Chen |
| author_sort | Siyu Liu |
| collection | DOAJ |
| description | Bacterial biofilms formed by pathogens are known to be hundreds of times more resistant to antimicrobial agents than planktonic cells, making it extremely difficult to cure biofilm-based infections despite the use of antibiotics, which poses a serious threat to human health. Therefore, there is an urgent need to develop promising alternative antimicrobial therapies to reduce the burden of drug-resistant bacterial infections caused by biofilms. As natural enemies of bacteria, bacteriophages (phages) have the advantages of high specificity, safety and non-toxicity, and possess great potential in the defense and removal of pathogenic bacterial biofilms, which are considered to be alternatives to treat bacterial diseases. This work mainly reviews the composition, structure and formation process of bacterial biofilms, briefly discusses the interaction between phages and biofilms, and summarizes several strategies based on phages and their derivatives against biofilms and drug-resistant bacterial infections caused by biofilms, serving the purpose of developing novel, safe and effective treatment methods against biofilm-based infections and promoting the application of phages in maintaining human health. |
| first_indexed | 2024-03-09T21:13:56Z |
| format | Article |
| id | doaj.art-5d8c4d8f7eda4e07acf7f7c6d682a1c9 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T21:13:56Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-5d8c4d8f7eda4e07acf7f7c6d682a1c92023-11-23T21:39:09ZengMDPI AGPharmaceutics1999-49232022-02-0114242710.3390/pharmaceutics14020427Phages against Pathogenic Bacterial Biofilms and Biofilm-Based Infections: A ReviewSiyu Liu0Hongyun Lu1Shengliang Zhang2Ying Shi3Qihe Chen4Department of Food Science and Nutrition, Zhejiang University, Hangzhou 310058, ChinaDepartment of Food Science and Nutrition, Zhejiang University, Hangzhou 310058, ChinaDepartment of Food Science and Nutrition, Zhejiang University, Hangzhou 310058, ChinaDepartment of Food Science and Nutrition, Zhejiang University, Hangzhou 310058, ChinaDepartment of Food Science and Nutrition, Zhejiang University, Hangzhou 310058, ChinaBacterial biofilms formed by pathogens are known to be hundreds of times more resistant to antimicrobial agents than planktonic cells, making it extremely difficult to cure biofilm-based infections despite the use of antibiotics, which poses a serious threat to human health. Therefore, there is an urgent need to develop promising alternative antimicrobial therapies to reduce the burden of drug-resistant bacterial infections caused by biofilms. As natural enemies of bacteria, bacteriophages (phages) have the advantages of high specificity, safety and non-toxicity, and possess great potential in the defense and removal of pathogenic bacterial biofilms, which are considered to be alternatives to treat bacterial diseases. This work mainly reviews the composition, structure and formation process of bacterial biofilms, briefly discusses the interaction between phages and biofilms, and summarizes several strategies based on phages and their derivatives against biofilms and drug-resistant bacterial infections caused by biofilms, serving the purpose of developing novel, safe and effective treatment methods against biofilm-based infections and promoting the application of phages in maintaining human health.https://www.mdpi.com/1999-4923/14/2/427bacterial biofilmphagepathogenic bacterial biofilm controlphage therapybiofilm-based infections |
| spellingShingle | Siyu Liu Hongyun Lu Shengliang Zhang Ying Shi Qihe Chen Phages against Pathogenic Bacterial Biofilms and Biofilm-Based Infections: A Review Pharmaceutics bacterial biofilm phage pathogenic bacterial biofilm control phage therapy biofilm-based infections |
| title | Phages against Pathogenic Bacterial Biofilms and Biofilm-Based Infections: A Review |
| title_full | Phages against Pathogenic Bacterial Biofilms and Biofilm-Based Infections: A Review |
| title_fullStr | Phages against Pathogenic Bacterial Biofilms and Biofilm-Based Infections: A Review |
| title_full_unstemmed | Phages against Pathogenic Bacterial Biofilms and Biofilm-Based Infections: A Review |
| title_short | Phages against Pathogenic Bacterial Biofilms and Biofilm-Based Infections: A Review |
| title_sort | phages against pathogenic bacterial biofilms and biofilm based infections a review |
| topic | bacterial biofilm phage pathogenic bacterial biofilm control phage therapy biofilm-based infections |
| url | https://www.mdpi.com/1999-4923/14/2/427 |
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