Quantitative Assessment of the Echogenicity of a Breast Tumor Predicts the Response to Neoadjuvant Chemotherapy
The aim of the study was to improve monitoring the treatment response in breast cancer patients undergoing neoadjuvant chemotherapy (NAC). The IRB approved this prospective study. Ultrasound examinations were performed prior to treatment and 7 days after four consecutive NAC cycles. Residual maligna...
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| Format: | Article |
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MDPI AG
2021-07-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/13/14/3546 |
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| author | Katarzyna Sylwia Dobruch-Sobczak Hanna Piotrzkowska-Wróblewska Piotr Karwat Ziemowit Klimonda Ewa Markiewicz-Grodzicka Jerzy Litniewski |
| author_facet | Katarzyna Sylwia Dobruch-Sobczak Hanna Piotrzkowska-Wróblewska Piotr Karwat Ziemowit Klimonda Ewa Markiewicz-Grodzicka Jerzy Litniewski |
| author_sort | Katarzyna Sylwia Dobruch-Sobczak |
| collection | DOAJ |
| description | The aim of the study was to improve monitoring the treatment response in breast cancer patients undergoing neoadjuvant chemotherapy (NAC). The IRB approved this prospective study. Ultrasound examinations were performed prior to treatment and 7 days after four consecutive NAC cycles. Residual malignant cell (RMC) measurement at surgery was the standard of reference. Alteration in B-mode ultrasound (tumor echogenicity and volume) and the Kullback-Leibler divergence (kld), as a quantitative measure of amplitude difference, were used. Correlations of these parameters with RMC were assessed and Receiver Operating Characteristic curve (ROC) analysis was performed. Thirty-nine patients (mean age 57 y.) with 50 tumors were included. There was a significant correlation between RMC and changes in quantitative parameters (KLD) after the second, third and fourth course of NAC, and alteration in echogenicity after the third and fourth course. Multivariate analysis of the echogenicity and KLD after the third NAC course revealed a sensitivity of 91%, specificity of 92%, PPV = 77%, NPV = 97%, accuracy = 91%, and AUC of 0.92 for non-responding tumors (RMC ≥ 70%). In conclusion, monitoring the echogenicity and KLD parameters made it possible to accurately predict the treatment response from the second course of NAC. |
| first_indexed | 2024-03-10T09:44:00Z |
| format | Article |
| id | doaj.art-5d8f146144a84a61b953866f06035e4a |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T09:44:00Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-5d8f146144a84a61b953866f06035e4a2023-11-22T03:25:06ZengMDPI AGCancers2072-66942021-07-011314354610.3390/cancers13143546Quantitative Assessment of the Echogenicity of a Breast Tumor Predicts the Response to Neoadjuvant ChemotherapyKatarzyna Sylwia Dobruch-Sobczak0Hanna Piotrzkowska-Wróblewska1Piotr Karwat2Ziemowit Klimonda3Ewa Markiewicz-Grodzicka4Jerzy Litniewski5Ultrasound Department, Institute of Fundamental Technological Research, Polish Academy of Sciences, Pawińskiego 5B, 02-106 Warsaw, PolandUltrasound Department, Institute of Fundamental Technological Research, Polish Academy of Sciences, Pawińskiego 5B, 02-106 Warsaw, PolandUltrasound Department, Institute of Fundamental Technological Research, Polish Academy of Sciences, Pawińskiego 5B, 02-106 Warsaw, PolandUltrasound Department, Institute of Fundamental Technological Research, Polish Academy of Sciences, Pawińskiego 5B, 02-106 Warsaw, PolandDepartment of Oncology and Radiotherapy, Maria Sklodowska-Curie National Research Institute of Oncology, 15 Wawelska St., 02-034 Warsaw, PolandUltrasound Department, Institute of Fundamental Technological Research, Polish Academy of Sciences, Pawińskiego 5B, 02-106 Warsaw, PolandThe aim of the study was to improve monitoring the treatment response in breast cancer patients undergoing neoadjuvant chemotherapy (NAC). The IRB approved this prospective study. Ultrasound examinations were performed prior to treatment and 7 days after four consecutive NAC cycles. Residual malignant cell (RMC) measurement at surgery was the standard of reference. Alteration in B-mode ultrasound (tumor echogenicity and volume) and the Kullback-Leibler divergence (kld), as a quantitative measure of amplitude difference, were used. Correlations of these parameters with RMC were assessed and Receiver Operating Characteristic curve (ROC) analysis was performed. Thirty-nine patients (mean age 57 y.) with 50 tumors were included. There was a significant correlation between RMC and changes in quantitative parameters (KLD) after the second, third and fourth course of NAC, and alteration in echogenicity after the third and fourth course. Multivariate analysis of the echogenicity and KLD after the third NAC course revealed a sensitivity of 91%, specificity of 92%, PPV = 77%, NPV = 97%, accuracy = 91%, and AUC of 0.92 for non-responding tumors (RMC ≥ 70%). In conclusion, monitoring the echogenicity and KLD parameters made it possible to accurately predict the treatment response from the second course of NAC.https://www.mdpi.com/2072-6694/13/14/3546quantitative ultrasoundB-mode ultrasoundechogenicitybreast cancerneoadjuvant chemotherapy |
| spellingShingle | Katarzyna Sylwia Dobruch-Sobczak Hanna Piotrzkowska-Wróblewska Piotr Karwat Ziemowit Klimonda Ewa Markiewicz-Grodzicka Jerzy Litniewski Quantitative Assessment of the Echogenicity of a Breast Tumor Predicts the Response to Neoadjuvant Chemotherapy Cancers quantitative ultrasound B-mode ultrasound echogenicity breast cancer neoadjuvant chemotherapy |
| title | Quantitative Assessment of the Echogenicity of a Breast Tumor Predicts the Response to Neoadjuvant Chemotherapy |
| title_full | Quantitative Assessment of the Echogenicity of a Breast Tumor Predicts the Response to Neoadjuvant Chemotherapy |
| title_fullStr | Quantitative Assessment of the Echogenicity of a Breast Tumor Predicts the Response to Neoadjuvant Chemotherapy |
| title_full_unstemmed | Quantitative Assessment of the Echogenicity of a Breast Tumor Predicts the Response to Neoadjuvant Chemotherapy |
| title_short | Quantitative Assessment of the Echogenicity of a Breast Tumor Predicts the Response to Neoadjuvant Chemotherapy |
| title_sort | quantitative assessment of the echogenicity of a breast tumor predicts the response to neoadjuvant chemotherapy |
| topic | quantitative ultrasound B-mode ultrasound echogenicity breast cancer neoadjuvant chemotherapy |
| url | https://www.mdpi.com/2072-6694/13/14/3546 |
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