The Effects of Ionizing Radiation on Gut Microbiota: What Can Animal Models Tell Us?—A Systematic Review
Background: The gut microbiota is relatively stable; however, various factors can precipitate an imbalance that is known to be associated with various diseases. We aimed to conduct a systematic literature review of studies reporting the effects of ionizing radiation on the composition, richness, and...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | Current Issues in Molecular Biology |
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| Online Access: | https://www.mdpi.com/1467-3045/45/5/249 |
| _version_ | 1797600546379530240 |
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| author | Ana Fernandes Ana Oliveira Raquel Soares Pedro Barata |
| author_facet | Ana Fernandes Ana Oliveira Raquel Soares Pedro Barata |
| author_sort | Ana Fernandes |
| collection | DOAJ |
| description | Background: The gut microbiota is relatively stable; however, various factors can precipitate an imbalance that is known to be associated with various diseases. We aimed to conduct a systematic literature review of studies reporting the effects of ionizing radiation on the composition, richness, and diversity of the gut microbiota of animals. Methods: A systematic literature search was performed in PubMed, EMBASE, and Cochrane library databases. The standard methodologies expected by Cochrane were utilized. Results: We identified 3531 non-duplicated records and selected twenty-nine studies after considering the defined inclusion criteria. The studies were found to be heterogeneous, with significant differences in the chosen populations, methodologies, and outcomes. Overall, we found evidence of an association between ionizing radiation exposure and dysbiosis, with a reduction of microbiota diversity and richness and alterations in the taxonomic composition. Although differences in taxonomic composition varied across studies, Proteobacteria, Verrucomicrobia, <i>Alistipes</i>, and <i>Akkermancia</i> most consistently reported to be relatively more abundant after ionizing radiation exposure, whereas Bacteroidetes, Firmicutes, and <i>Lactobacillus</i> were relatively reduced. Conclusions: This review highlights the effect of ionizing exposure on gut microbiota diversity, richness, and composition. It paves the way for further studies on human subjects regarding gastrointestinal side effects in patients submitted to treatments with ionizing radiation and the development of potential preventive, therapeutic approaches. |
| first_indexed | 2024-03-11T03:50:42Z |
| format | Article |
| id | doaj.art-5d8f406232074dce9c7651176f44a6e9 |
| institution | Directory Open Access Journal |
| issn | 1467-3037 1467-3045 |
| language | English |
| last_indexed | 2024-03-11T03:50:42Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Issues in Molecular Biology |
| spelling | doaj.art-5d8f406232074dce9c7651176f44a6e92023-11-18T00:56:50ZengMDPI AGCurrent Issues in Molecular Biology1467-30371467-30452023-05-014553877391010.3390/cimb45050249The Effects of Ionizing Radiation on Gut Microbiota: What Can Animal Models Tell Us?—A Systematic ReviewAna Fernandes0Ana Oliveira1Raquel Soares2Pedro Barata3Department Nuclear Medicine, Centro Hospitalar e Universitário de São João, E.P.E., 4200-319 Porto, PortugalDepartment Nuclear Medicine, Centro Hospitalar e Universitário de São João, E.P.E., 4200-319 Porto, Portugali3S—Institute for Research and Innovation in Health, Universidade do Porto, 4200-135 Porto, Portugali3S—Institute for Research and Innovation in Health, Universidade do Porto, 4200-135 Porto, PortugalBackground: The gut microbiota is relatively stable; however, various factors can precipitate an imbalance that is known to be associated with various diseases. We aimed to conduct a systematic literature review of studies reporting the effects of ionizing radiation on the composition, richness, and diversity of the gut microbiota of animals. Methods: A systematic literature search was performed in PubMed, EMBASE, and Cochrane library databases. The standard methodologies expected by Cochrane were utilized. Results: We identified 3531 non-duplicated records and selected twenty-nine studies after considering the defined inclusion criteria. The studies were found to be heterogeneous, with significant differences in the chosen populations, methodologies, and outcomes. Overall, we found evidence of an association between ionizing radiation exposure and dysbiosis, with a reduction of microbiota diversity and richness and alterations in the taxonomic composition. Although differences in taxonomic composition varied across studies, Proteobacteria, Verrucomicrobia, <i>Alistipes</i>, and <i>Akkermancia</i> most consistently reported to be relatively more abundant after ionizing radiation exposure, whereas Bacteroidetes, Firmicutes, and <i>Lactobacillus</i> were relatively reduced. Conclusions: This review highlights the effect of ionizing exposure on gut microbiota diversity, richness, and composition. It paves the way for further studies on human subjects regarding gastrointestinal side effects in patients submitted to treatments with ionizing radiation and the development of potential preventive, therapeutic approaches.https://www.mdpi.com/1467-3045/45/5/249microbiomemicrobiotaintestinal microbiomegut microbiotaionizing radiationradiotherapy |
| spellingShingle | Ana Fernandes Ana Oliveira Raquel Soares Pedro Barata The Effects of Ionizing Radiation on Gut Microbiota: What Can Animal Models Tell Us?—A Systematic Review Current Issues in Molecular Biology microbiome microbiota intestinal microbiome gut microbiota ionizing radiation radiotherapy |
| title | The Effects of Ionizing Radiation on Gut Microbiota: What Can Animal Models Tell Us?—A Systematic Review |
| title_full | The Effects of Ionizing Radiation on Gut Microbiota: What Can Animal Models Tell Us?—A Systematic Review |
| title_fullStr | The Effects of Ionizing Radiation on Gut Microbiota: What Can Animal Models Tell Us?—A Systematic Review |
| title_full_unstemmed | The Effects of Ionizing Radiation on Gut Microbiota: What Can Animal Models Tell Us?—A Systematic Review |
| title_short | The Effects of Ionizing Radiation on Gut Microbiota: What Can Animal Models Tell Us?—A Systematic Review |
| title_sort | effects of ionizing radiation on gut microbiota what can animal models tell us a systematic review |
| topic | microbiome microbiota intestinal microbiome gut microbiota ionizing radiation radiotherapy |
| url | https://www.mdpi.com/1467-3045/45/5/249 |
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