Proliferation, angiogenesis and differentiation related markers in compact and follicular-compact thyroid carcinomas in dogs
Immunohistochemical markers (IGF-1, IGF-1R, VEGF, FGF-2, RARα and RXR) were evaluated in healthy canine thyroid glands (n=8) and in follicular-compact (n=8) and compact thyroid carcinomas (n=8). IGF-1, IGF-1R and VEGF expression was higher in fibroblasts and endothelial cells of compact carcinoma th...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Tripoli University
2016-12-01
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| Series: | Open Veterinary Journal |
| Subjects: | |
| Online Access: | http://www.openveterinaryjournal.com/2016/Volume%206%20(3)/OVJ-141-06-16%20P.%20Pessina%20et%20al.pdf |
| _version_ | 1818398159593799680 |
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| author | P. Pessina V.A. Castillo D. César I. Sartore A. Meikle |
| author_facet | P. Pessina V.A. Castillo D. César I. Sartore A. Meikle |
| author_sort | P. Pessina |
| collection | DOAJ |
| description | Immunohistochemical markers (IGF-1, IGF-1R, VEGF, FGF-2, RARα and RXR) were evaluated in healthy canine thyroid glands (n=8) and in follicular-compact (n=8) and compact thyroid carcinomas (n=8). IGF-1, IGF-1R and VEGF expression was higher in fibroblasts and endothelial cells of compact carcinoma than in healthy glands (P < 0.05). Compared to follicular-compact carcinoma, compact carcinoma had higher IGF-1R expression in fibroblasts, and higher FGF-2 expression in endothelial cells (P < 0.05). RARα expression was higher in endothelial cells of compact carcinoma than in those of other groups (P < 0.05). The upregulation of these proliferation- and angiogenesis-related factors in endothelial cells and/or fibroblasts and not in follicular cells of compact carcinoma compared to healthy glands supports the relevance of stromal cells in cancer progression. |
| first_indexed | 2024-12-14T07:00:21Z |
| format | Article |
| id | doaj.art-5d8feaaabcb6404d9ac357cb303b6bad |
| institution | Directory Open Access Journal |
| issn | 2218-6050 2218-6050 |
| language | English |
| last_indexed | 2024-12-14T07:00:21Z |
| publishDate | 2016-12-01 |
| publisher | Tripoli University |
| record_format | Article |
| series | Open Veterinary Journal |
| spelling | doaj.art-5d8feaaabcb6404d9ac357cb303b6bad2022-12-21T23:12:26ZengTripoli UniversityOpen Veterinary Journal2218-60502218-60502016-12-0163247254http://dx.doi.org/10.4314/ovj.v6i3.15Proliferation, angiogenesis and differentiation related markers in compact and follicular-compact thyroid carcinomas in dogsP. PessinaV.A. CastilloD. CésarI. SartoreA. MeikleImmunohistochemical markers (IGF-1, IGF-1R, VEGF, FGF-2, RARα and RXR) were evaluated in healthy canine thyroid glands (n=8) and in follicular-compact (n=8) and compact thyroid carcinomas (n=8). IGF-1, IGF-1R and VEGF expression was higher in fibroblasts and endothelial cells of compact carcinoma than in healthy glands (P < 0.05). Compared to follicular-compact carcinoma, compact carcinoma had higher IGF-1R expression in fibroblasts, and higher FGF-2 expression in endothelial cells (P < 0.05). RARα expression was higher in endothelial cells of compact carcinoma than in those of other groups (P < 0.05). The upregulation of these proliferation- and angiogenesis-related factors in endothelial cells and/or fibroblasts and not in follicular cells of compact carcinoma compared to healthy glands supports the relevance of stromal cells in cancer progression.http://www.openveterinaryjournal.com/2016/Volume%206%20(3)/OVJ-141-06-16%20P.%20Pessina%20et%20al.pdfCanineHistologyImmunohistochemistryThyroid carcinoma |
| spellingShingle | P. Pessina V.A. Castillo D. César I. Sartore A. Meikle Proliferation, angiogenesis and differentiation related markers in compact and follicular-compact thyroid carcinomas in dogs Open Veterinary Journal Canine Histology Immunohistochemistry Thyroid carcinoma |
| title | Proliferation, angiogenesis and differentiation related markers in compact and follicular-compact thyroid carcinomas in dogs |
| title_full | Proliferation, angiogenesis and differentiation related markers in compact and follicular-compact thyroid carcinomas in dogs |
| title_fullStr | Proliferation, angiogenesis and differentiation related markers in compact and follicular-compact thyroid carcinomas in dogs |
| title_full_unstemmed | Proliferation, angiogenesis and differentiation related markers in compact and follicular-compact thyroid carcinomas in dogs |
| title_short | Proliferation, angiogenesis and differentiation related markers in compact and follicular-compact thyroid carcinomas in dogs |
| title_sort | proliferation angiogenesis and differentiation related markers in compact and follicular compact thyroid carcinomas in dogs |
| topic | Canine Histology Immunohistochemistry Thyroid carcinoma |
| url | http://www.openveterinaryjournal.com/2016/Volume%206%20(3)/OVJ-141-06-16%20P.%20Pessina%20et%20al.pdf |
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