Genetic Markers for Later Remission in Response to Early Improvement of Antidepressants
Planning subsequent treatment strategies based on early responses rather than waiting for delayed antidepressant action can be helpful. We identified genetic markers for later non-remission in patients exhibiting poor early improvement using whole-exome sequencing data of depressive patients treated...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-07-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/21/14/4884 |
| Summary: | Planning subsequent treatment strategies based on early responses rather than waiting for delayed antidepressant action can be helpful. We identified genetic markers for later non-remission in patients exhibiting poor early improvement using whole-exome sequencing data of depressive patients treated in a naturalistic manner. Among 1000 patients, early improvement at 2 weeks (reduction in Hamilton Depression Rating Scale [HAM-D] score ≥ 20%) and remission at 12 weeks (HAM-D score ≤ 7) were evaluated. Gene- and variant-level analyses were conducted to compare patients who did not exhibit early improvement and did not eventually achieve remission (<i>n</i> = 126) with those who exhibited early improvement and achieved remission (<i>n</i> = 385). Genes predicting final non-remission in patients who exhibited poor early improvement (<i>COMT, PRNP</i>, <i>BRPF3</i>, <i>SLC25A40,</i> and <i>CGREF1</i> in males; <i>PPFIBPI</i>, <i>LZTS3, MEPCE, MAP1A,</i> and <i>PFAS</i> in females; <i>ST3GAL5</i> in the total population) were determined. Among the significant genes, variants in the <i>PRNP</i> (rs1800014), <i>COMT</i> (rs6267), <i>BRPF3</i> (rs200565609), and <i>SLC25A40</i> genes (rs3213633) were identified. However, interpretations should be made cautiously, as complex pharmacotherapy involves various genes and pathways. Early detection of poor early improvement and final non-remission based on genetic risk would be helpful for decision-making in a clinical setting. |
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| ISSN: | 1661-6596 1422-0067 |