Long Pentraxin-3 Follows and Modulates Bladder Cancer Progression
Bladder tumors are a diffuse type of cancer. Long pentraxin-3 (PTX3) is a component of the innate immunity with pleiotropic functions in the regulation of immune response, tissue remodeling, and cancer progression. PTX3 may act as an oncosuppressor in different contexts, functioning as an antagonist...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-08-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/11/9/1277 |
| _version_ | 1797708739557457920 |
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| author | Sara Matarazzo Laura Melocchi Sara Rezzola Elisabetta Grillo Federica Maccarinelli Arianna Giacomini Marta Turati Sara Taranto Luca Zammataro Marianna Cerasuolo Mattia Bugatti William Vermi Marco Presta Roberto Ronca |
| author_facet | Sara Matarazzo Laura Melocchi Sara Rezzola Elisabetta Grillo Federica Maccarinelli Arianna Giacomini Marta Turati Sara Taranto Luca Zammataro Marianna Cerasuolo Mattia Bugatti William Vermi Marco Presta Roberto Ronca |
| author_sort | Sara Matarazzo |
| collection | DOAJ |
| description | Bladder tumors are a diffuse type of cancer. Long pentraxin-3 (PTX3) is a component of the innate immunity with pleiotropic functions in the regulation of immune response, tissue remodeling, and cancer progression. PTX3 may act as an oncosuppressor in different contexts, functioning as an antagonist of the fibroblast growth factor/fibroblast growth factor receptor (FGF/FGFR) system, rewiring the immune microenvironment, or acting through mechanisms not yet fully clarified. In this study we used biopsies and data mining to assess that PTX3 is differentially expressed during the different stages of bladder cancer (BC) progression. BC cell lines, representative of different tumor grades, and transgenic/carcinogen-induced models were used to demonstrate in vitro and in vivo that PTX3 production by tumor cells decreases along the progression from low-grade to high-grade advanced muscle invasive forms (MIBC). In vitro and in vivo data revealed for the first time that PTX3 modulation and the consequent impairment of FGF/FGR systems in BC cells have a significant impact on different biological features of BC growth, including cell proliferation, motility, metabolism, stemness, and drug resistance. PTX3 exerts an oncosuppressive effect on BC progression and may represent a potential functional biomarker in BC evolution. Moreover, FGF/FGFR blockade has an impact on drug resistance and stemness features in BC. |
| first_indexed | 2024-03-12T06:26:54Z |
| format | Article |
| id | doaj.art-5d921f464e714e8a8f56a52eceec3d33 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T06:26:54Z |
| publishDate | 2019-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-5d921f464e714e8a8f56a52eceec3d332023-09-03T01:52:03ZengMDPI AGCancers2072-66942019-08-01119127710.3390/cancers11091277cancers11091277Long Pentraxin-3 Follows and Modulates Bladder Cancer ProgressionSara Matarazzo0Laura Melocchi1Sara Rezzola2Elisabetta Grillo3Federica Maccarinelli4Arianna Giacomini5Marta Turati6Sara Taranto7Luca Zammataro8Marianna Cerasuolo9Mattia Bugatti10William Vermi11Marco Presta12Roberto Ronca13Department of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, ItalyDepartment of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, ItalyDepartment of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, ItalyDepartment of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, ItalyDepartment of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, ItalyDepartment of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, ItalyDepartment of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, ItalyDepartment of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, ItalyDepartment of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520, USASchool of Mathematics and Physics, University of Portsmouth, Hampshire PO1 3HF, UKDepartment of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, ItalyDepartment of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, ItalyDepartment of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, ItalyDepartment of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, ItalyBladder tumors are a diffuse type of cancer. Long pentraxin-3 (PTX3) is a component of the innate immunity with pleiotropic functions in the regulation of immune response, tissue remodeling, and cancer progression. PTX3 may act as an oncosuppressor in different contexts, functioning as an antagonist of the fibroblast growth factor/fibroblast growth factor receptor (FGF/FGFR) system, rewiring the immune microenvironment, or acting through mechanisms not yet fully clarified. In this study we used biopsies and data mining to assess that PTX3 is differentially expressed during the different stages of bladder cancer (BC) progression. BC cell lines, representative of different tumor grades, and transgenic/carcinogen-induced models were used to demonstrate in vitro and in vivo that PTX3 production by tumor cells decreases along the progression from low-grade to high-grade advanced muscle invasive forms (MIBC). In vitro and in vivo data revealed for the first time that PTX3 modulation and the consequent impairment of FGF/FGR systems in BC cells have a significant impact on different biological features of BC growth, including cell proliferation, motility, metabolism, stemness, and drug resistance. PTX3 exerts an oncosuppressive effect on BC progression and may represent a potential functional biomarker in BC evolution. Moreover, FGF/FGFR blockade has an impact on drug resistance and stemness features in BC.https://www.mdpi.com/2072-6694/11/9/1277long pentraxin-3bladder cancerFGFFGFRstemnessmetabolism |
| spellingShingle | Sara Matarazzo Laura Melocchi Sara Rezzola Elisabetta Grillo Federica Maccarinelli Arianna Giacomini Marta Turati Sara Taranto Luca Zammataro Marianna Cerasuolo Mattia Bugatti William Vermi Marco Presta Roberto Ronca Long Pentraxin-3 Follows and Modulates Bladder Cancer Progression Cancers long pentraxin-3 bladder cancer FGF FGFR stemness metabolism |
| title | Long Pentraxin-3 Follows and Modulates Bladder Cancer Progression |
| title_full | Long Pentraxin-3 Follows and Modulates Bladder Cancer Progression |
| title_fullStr | Long Pentraxin-3 Follows and Modulates Bladder Cancer Progression |
| title_full_unstemmed | Long Pentraxin-3 Follows and Modulates Bladder Cancer Progression |
| title_short | Long Pentraxin-3 Follows and Modulates Bladder Cancer Progression |
| title_sort | long pentraxin 3 follows and modulates bladder cancer progression |
| topic | long pentraxin-3 bladder cancer FGF FGFR stemness metabolism |
| url | https://www.mdpi.com/2072-6694/11/9/1277 |
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