Assessment of dynamic cerebral autoregulation in near-infrared spectroscopy using short channels: A feasibility study in acute ischemic stroke patients
IntroductionIn acute ischemic stroke, progressive impairment of cerebral autoregulation (CA) is frequent and associated with unfavorable outcomes. Easy assessment of cerebral blood flow and CA in stroke units bedside tools like near-infrared spectroscopy (NIRS) might improve early detection of CA de...
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2022.1028864/full |
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| author | Sabeth Becker Franziska Klein Katja König Katja König Christian Mathys Christian Mathys Thomas Liman Thomas Liman Karsten Witt Karsten Witt Karsten Witt |
| author_facet | Sabeth Becker Franziska Klein Katja König Katja König Christian Mathys Christian Mathys Thomas Liman Thomas Liman Karsten Witt Karsten Witt Karsten Witt |
| author_sort | Sabeth Becker |
| collection | DOAJ |
| description | IntroductionIn acute ischemic stroke, progressive impairment of cerebral autoregulation (CA) is frequent and associated with unfavorable outcomes. Easy assessment of cerebral blood flow and CA in stroke units bedside tools like near-infrared spectroscopy (NIRS) might improve early detection of CA deterioration. This study aimed to assess dynamic CA with multichannel CW-NIRS in acute ischemic stroke (AIS) patients compared to agematched healthy controls.MethodsCA reaction was amplified by changes in head of bed position. Long- and short channels were used to monitor systemic artery pressure- and intracranial oscillations simultaneously. Gain and phase shift in spontaneous low- and very low-frequency oscillations (LFO, VLFO) of blood pressure were assessed.ResultsA total of 54 participants, 27 with AIS and 27 age-matched controls were included. Gain was significantly lower in the AIS group in the LFO range (i) when the upper body was steadily elevated to 30. and (ii) after its abrupt elevation to 30°. No other differences were found between groups.DiscussionThis study demonstrates the feasibility of NIRS short channels to measure CA in AIS patients in one single instrument. A lower gain in AIS might indicate decreased CA activity in this pilot study, but further studies investigating the role of NIRS short channels in AIS are needed. |
| first_indexed | 2024-04-12T07:28:12Z |
| format | Article |
| id | doaj.art-5d92be8b474e4e558db2797a2b0c9b2d |
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| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-12T07:28:12Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Neurology |
| spelling | doaj.art-5d92be8b474e4e558db2797a2b0c9b2d2022-12-22T03:42:09ZengFrontiers Media S.A.Frontiers in Neurology1664-22952022-11-011310.3389/fneur.2022.10288641028864Assessment of dynamic cerebral autoregulation in near-infrared spectroscopy using short channels: A feasibility study in acute ischemic stroke patientsSabeth Becker0Franziska Klein1Katja König2Katja König3Christian Mathys4Christian Mathys5Thomas Liman6Thomas Liman7Karsten Witt8Karsten Witt9Karsten Witt10Department of Neurology, School of Medicine and Health Sciences, Carl von Ossietzky University of Oldenburg, Oldenburg, GermanyNeurocognition and Functional Neurorehabilitation Group, Neuropsychology Lab, Department of Psychology, Faculty of Medicine and Health Sciences, University of Oldenburg, Oldenburg, GermanyDepartment of Neurology, School of Medicine and Health Sciences, Carl von Ossietzky University of Oldenburg, Oldenburg, GermanyUniversity Clinic for Neurology, Evangelical Hospital, Oldenburg, GermanyInstitute of Radiology and Neuroradiology, Evangelical Hospital, Oldenburg, GermanyResearch Centre Neurosensory Science, Department of Human Medicine, Faculty of Medicine and Health Sciences, University of Oldenburg, Oldenburg, GermanyDepartment of Neurology, School of Medicine and Health Sciences, Carl von Ossietzky University of Oldenburg, Oldenburg, GermanyUniversity Clinic for Neurology, Evangelical Hospital, Oldenburg, GermanyDepartment of Neurology, School of Medicine and Health Sciences, Carl von Ossietzky University of Oldenburg, Oldenburg, GermanyUniversity Clinic for Neurology, Evangelical Hospital, Oldenburg, GermanyInstitute of Radiology and Neuroradiology, Evangelical Hospital, Oldenburg, GermanyIntroductionIn acute ischemic stroke, progressive impairment of cerebral autoregulation (CA) is frequent and associated with unfavorable outcomes. Easy assessment of cerebral blood flow and CA in stroke units bedside tools like near-infrared spectroscopy (NIRS) might improve early detection of CA deterioration. This study aimed to assess dynamic CA with multichannel CW-NIRS in acute ischemic stroke (AIS) patients compared to agematched healthy controls.MethodsCA reaction was amplified by changes in head of bed position. Long- and short channels were used to monitor systemic artery pressure- and intracranial oscillations simultaneously. Gain and phase shift in spontaneous low- and very low-frequency oscillations (LFO, VLFO) of blood pressure were assessed.ResultsA total of 54 participants, 27 with AIS and 27 age-matched controls were included. Gain was significantly lower in the AIS group in the LFO range (i) when the upper body was steadily elevated to 30. and (ii) after its abrupt elevation to 30°. No other differences were found between groups.DiscussionThis study demonstrates the feasibility of NIRS short channels to measure CA in AIS patients in one single instrument. A lower gain in AIS might indicate decreased CA activity in this pilot study, but further studies investigating the role of NIRS short channels in AIS are needed.https://www.frontiersin.org/articles/10.3389/fneur.2022.1028864/fullacute ischaemic stroke (AIS)cerebral autoregulation (CA)cerebral blood flow (CBF)head of bed positioninglow-frequency oscillation (LFO)near-infrared spectroscopy (NIRS) |
| spellingShingle | Sabeth Becker Franziska Klein Katja König Katja König Christian Mathys Christian Mathys Thomas Liman Thomas Liman Karsten Witt Karsten Witt Karsten Witt Assessment of dynamic cerebral autoregulation in near-infrared spectroscopy using short channels: A feasibility study in acute ischemic stroke patients Frontiers in Neurology acute ischaemic stroke (AIS) cerebral autoregulation (CA) cerebral blood flow (CBF) head of bed positioning low-frequency oscillation (LFO) near-infrared spectroscopy (NIRS) |
| title | Assessment of dynamic cerebral autoregulation in near-infrared spectroscopy using short channels: A feasibility study in acute ischemic stroke patients |
| title_full | Assessment of dynamic cerebral autoregulation in near-infrared spectroscopy using short channels: A feasibility study in acute ischemic stroke patients |
| title_fullStr | Assessment of dynamic cerebral autoregulation in near-infrared spectroscopy using short channels: A feasibility study in acute ischemic stroke patients |
| title_full_unstemmed | Assessment of dynamic cerebral autoregulation in near-infrared spectroscopy using short channels: A feasibility study in acute ischemic stroke patients |
| title_short | Assessment of dynamic cerebral autoregulation in near-infrared spectroscopy using short channels: A feasibility study in acute ischemic stroke patients |
| title_sort | assessment of dynamic cerebral autoregulation in near infrared spectroscopy using short channels a feasibility study in acute ischemic stroke patients |
| topic | acute ischaemic stroke (AIS) cerebral autoregulation (CA) cerebral blood flow (CBF) head of bed positioning low-frequency oscillation (LFO) near-infrared spectroscopy (NIRS) |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2022.1028864/full |
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