Homeostatic Plasticity in the Hippocampus Facilitates Memory Extinction
Summary: Correlated activity in the hippocampus drives synaptic plasticity that is necessary for the recruitment of neuronal ensembles underlying fear memory. Sustained neural activity, on the other hand, may trigger homeostatic adaptations. However, whether homeostatic plasticity affects memory fun...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2018-02-01
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| Series: | Cell Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124718300421 |
| _version_ | 1818145964987252736 |
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| author | Pablo Mendez Thomas Stefanelli Carmen E. Flores Dominique Muller Christian Lüscher |
| author_facet | Pablo Mendez Thomas Stefanelli Carmen E. Flores Dominique Muller Christian Lüscher |
| author_sort | Pablo Mendez |
| collection | DOAJ |
| description | Summary: Correlated activity in the hippocampus drives synaptic plasticity that is necessary for the recruitment of neuronal ensembles underlying fear memory. Sustained neural activity, on the other hand, may trigger homeostatic adaptations. However, whether homeostatic plasticity affects memory function remains unknown. Here, we use optogenetics to induce cell autonomous homeostatic plasticity in CA1 pyramidal neurons and granule cells of the hippocampus. High-frequency spike trains applied for 10 min decreased the number of excitatory spine synapses and increased the number of inhibitory shaft synapses. This activity stopped dendritic spine formation via L-type voltage-dependent calcium channel activity and protein synthesis. Applied selectively to the ensemble of granule cells encoding a contextual fear memory, the spike trains impaired memory recall and facilitated extinction. Our results indicate that homeostatic plasticity triggered by optogenetic neuronal firing alters the balance between excitation and inhibition in favor of memory extinction. |
| first_indexed | 2024-12-11T12:11:50Z |
| format | Article |
| id | doaj.art-5d95b94dd6654cd095825cc2c486bf8e |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-12-11T12:11:50Z |
| publishDate | 2018-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-5d95b94dd6654cd095825cc2c486bf8e2022-12-22T01:07:46ZengElsevierCell Reports2211-12472018-02-012261451146110.1016/j.celrep.2018.01.025Homeostatic Plasticity in the Hippocampus Facilitates Memory ExtinctionPablo Mendez0Thomas Stefanelli1Carmen E. Flores2Dominique Muller3Christian Lüscher4Department of Basic Neurosciences, Faculty of Medicine, University of Geneva, Michel-Servet 1, 1211 Geneva, Switzerland; Corresponding authorDepartment of Basic Neurosciences, Faculty of Medicine, University of Geneva, Michel-Servet 1, 1211 Geneva, SwitzerlandDepartment of Basic Neurosciences, Faculty of Medicine, University of Geneva, Michel-Servet 1, 1211 Geneva, SwitzerlandDepartment of Basic Neurosciences, Faculty of Medicine, University of Geneva, Michel-Servet 1, 1211 Geneva, SwitzerlandDepartment of Basic Neurosciences, Faculty of Medicine, University of Geneva, Michel-Servet 1, 1211 Geneva, Switzerland; Service of Neurology, Geneva University Hospital, Perret-Gentil 4, 1211 Geneva, SwitzerlandSummary: Correlated activity in the hippocampus drives synaptic plasticity that is necessary for the recruitment of neuronal ensembles underlying fear memory. Sustained neural activity, on the other hand, may trigger homeostatic adaptations. However, whether homeostatic plasticity affects memory function remains unknown. Here, we use optogenetics to induce cell autonomous homeostatic plasticity in CA1 pyramidal neurons and granule cells of the hippocampus. High-frequency spike trains applied for 10 min decreased the number of excitatory spine synapses and increased the number of inhibitory shaft synapses. This activity stopped dendritic spine formation via L-type voltage-dependent calcium channel activity and protein synthesis. Applied selectively to the ensemble of granule cells encoding a contextual fear memory, the spike trains impaired memory recall and facilitated extinction. Our results indicate that homeostatic plasticity triggered by optogenetic neuronal firing alters the balance between excitation and inhibition in favor of memory extinction.http://www.sciencedirect.com/science/article/pii/S2211124718300421hippocampusdendritic spineinhibitory synapsehomeostatic plasticitystructural plasticity |
| spellingShingle | Pablo Mendez Thomas Stefanelli Carmen E. Flores Dominique Muller Christian Lüscher Homeostatic Plasticity in the Hippocampus Facilitates Memory Extinction Cell Reports hippocampus dendritic spine inhibitory synapse homeostatic plasticity structural plasticity |
| title | Homeostatic Plasticity in the Hippocampus Facilitates Memory Extinction |
| title_full | Homeostatic Plasticity in the Hippocampus Facilitates Memory Extinction |
| title_fullStr | Homeostatic Plasticity in the Hippocampus Facilitates Memory Extinction |
| title_full_unstemmed | Homeostatic Plasticity in the Hippocampus Facilitates Memory Extinction |
| title_short | Homeostatic Plasticity in the Hippocampus Facilitates Memory Extinction |
| title_sort | homeostatic plasticity in the hippocampus facilitates memory extinction |
| topic | hippocampus dendritic spine inhibitory synapse homeostatic plasticity structural plasticity |
| url | http://www.sciencedirect.com/science/article/pii/S2211124718300421 |
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