Structural requirements for Yersinia YopJ inhibition of MAP kinase pathways.

Structural requirements for Yersinia YopJ inhibition of MAP kinase pathways.

MAPK signaling cascades are evolutionally conserved. The bacterial effector, YopJ, uses the unique activity of Ser/Thr acetylation to inhibit the activation of the MAPK kinase (MKK) and prevent activation by phosphorylation. YopJ is also able to block yeast MAPK signaling pathways using this mechani...

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Bibliographic Details
Main Authors:	Yi-Heng Hao, Yong Wang, Dara Burdette, Sohini Mukherjee, Gladys Keitany, Elizabeth Goldsmith, Kim Orth
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2008-01-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC2147050?pdf=render

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