Applications of a Standardized Green Tea Catechin Preparation for Viral Warts and Human Papilloma Virus-Related and Unrelated Cancers
Most cell-based and animal experiments have shown that green tea catechins (GTC) exhibit various health benefits. In human experimental and epidemiological studies, there are conflicting results, and more precise investigations are required. One of the most effective ways to prove beneficial health...
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MDPI AG
2020-06-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/25/11/2588 |
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| author | Noriyuki Miyoshi Hiroki Tanabe Takuji Suzuki Koichi Saeki Yukihiko Hara |
| author_facet | Noriyuki Miyoshi Hiroki Tanabe Takuji Suzuki Koichi Saeki Yukihiko Hara |
| author_sort | Noriyuki Miyoshi |
| collection | DOAJ |
| description | Most cell-based and animal experiments have shown that green tea catechins (GTC) exhibit various health benefits. In human experimental and epidemiological studies, there are conflicting results, and more precise investigations are required. One of the most effective ways to prove beneficial health effects in humans might be clinical intervention studies. Polyphenon<sup>®</sup>E was developed as a standardized GTC preparation, which was approved by Food and Drug Administration of US in 2006 as a medication to treat genital warts (Veregen<sup>®</sup> or sinecatechins). Positive efficacy of Polyphenon<sup>®</sup>E/sinecatechins/Veregen<sup>®</sup> (PSV) on anogenital warts has been demonstrated in several epidemiological studies and there have been several case reports to show the clinical effectiveness of PSV. In addition, several studies have provided evidence to suggest that PSV is effective in other human papillomavirus (HPV)-related diseases, although some studies failed to show such effects. Since (−)-epigallocatechin gallate (EGCG) is the major component of PSV, the mechanism of the action of PSV might be deduced from that of EGCG. The microarray analysis of the biopsy samples from the patients suggested that apoptosis induction and the downregulation of inflammation are involved in the mechanism of the action of PSV in the clearance of anogenital warts. Cell-based and animal experiments using PSV also demonstrated effects similar to those elicited by EGCG, explaining how PSV works to induce apoptosis and exert anti-inflammatory actions in HPV-related diseases. Future studies would clarify what kinds of diseases respond effectively to PSV, showing health benefits of GTC and EGCG in humans. |
| first_indexed | 2024-03-10T19:24:42Z |
| format | Article |
| id | doaj.art-5d99825be2934544827bbaa53038db40 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T19:24:42Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-5d99825be2934544827bbaa53038db402023-11-20T02:39:23ZengMDPI AGMolecules1420-30492020-06-012511258810.3390/molecules25112588Applications of a Standardized Green Tea Catechin Preparation for Viral Warts and Human Papilloma Virus-Related and Unrelated CancersNoriyuki Miyoshi0Hiroki Tanabe1Takuji Suzuki2Koichi Saeki3Yukihiko Hara4Graduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, Shizuoka 422-8526, JapanFaculty of Health and Welfare Science, Nayoro City University, Nayoro, Hokkaido 096-8641, JapanFaculty of Agriculture, Yamagata University, Yamagata 990-8560, JapanRegenerative Medicine iPS Gateway Center Co., Ltd., Tokyo 150-0012, JapanTea Solutions, Hara Office Inc., Tokyo 130-0012, JapanMost cell-based and animal experiments have shown that green tea catechins (GTC) exhibit various health benefits. In human experimental and epidemiological studies, there are conflicting results, and more precise investigations are required. One of the most effective ways to prove beneficial health effects in humans might be clinical intervention studies. Polyphenon<sup>®</sup>E was developed as a standardized GTC preparation, which was approved by Food and Drug Administration of US in 2006 as a medication to treat genital warts (Veregen<sup>®</sup> or sinecatechins). Positive efficacy of Polyphenon<sup>®</sup>E/sinecatechins/Veregen<sup>®</sup> (PSV) on anogenital warts has been demonstrated in several epidemiological studies and there have been several case reports to show the clinical effectiveness of PSV. In addition, several studies have provided evidence to suggest that PSV is effective in other human papillomavirus (HPV)-related diseases, although some studies failed to show such effects. Since (−)-epigallocatechin gallate (EGCG) is the major component of PSV, the mechanism of the action of PSV might be deduced from that of EGCG. The microarray analysis of the biopsy samples from the patients suggested that apoptosis induction and the downregulation of inflammation are involved in the mechanism of the action of PSV in the clearance of anogenital warts. Cell-based and animal experiments using PSV also demonstrated effects similar to those elicited by EGCG, explaining how PSV works to induce apoptosis and exert anti-inflammatory actions in HPV-related diseases. Future studies would clarify what kinds of diseases respond effectively to PSV, showing health benefits of GTC and EGCG in humans.https://www.mdpi.com/1420-3049/25/11/2588green tea catechinsepigallocatechin gallatehuman papillomavirusgene expression |
| spellingShingle | Noriyuki Miyoshi Hiroki Tanabe Takuji Suzuki Koichi Saeki Yukihiko Hara Applications of a Standardized Green Tea Catechin Preparation for Viral Warts and Human Papilloma Virus-Related and Unrelated Cancers Molecules green tea catechins epigallocatechin gallate human papillomavirus gene expression |
| title | Applications of a Standardized Green Tea Catechin Preparation for Viral Warts and Human Papilloma Virus-Related and Unrelated Cancers |
| title_full | Applications of a Standardized Green Tea Catechin Preparation for Viral Warts and Human Papilloma Virus-Related and Unrelated Cancers |
| title_fullStr | Applications of a Standardized Green Tea Catechin Preparation for Viral Warts and Human Papilloma Virus-Related and Unrelated Cancers |
| title_full_unstemmed | Applications of a Standardized Green Tea Catechin Preparation for Viral Warts and Human Papilloma Virus-Related and Unrelated Cancers |
| title_short | Applications of a Standardized Green Tea Catechin Preparation for Viral Warts and Human Papilloma Virus-Related and Unrelated Cancers |
| title_sort | applications of a standardized green tea catechin preparation for viral warts and human papilloma virus related and unrelated cancers |
| topic | green tea catechins epigallocatechin gallate human papillomavirus gene expression |
| url | https://www.mdpi.com/1420-3049/25/11/2588 |
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