EFFECTS OF CARVEDILOL AND METOPROLOL ON VEGETATIVE REGULATION OF HEART AND MICROCIRCULATION IN PATIENTS WITH HYPERTENSION AND HIGH BODY MASS
Aim. To study effects of carvedilol and metoprolol on vegetative regulation of heart and microcirculatory vessels in patients with arterial hypertension (HT) of 1-2 degrees and high body mass/obesity.Material and methods. Patients with HT of 1-2 degrees (n=25; aged 51±8 y.o.) were included in the st...
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| Format: | Article |
| Language: | English |
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Столичная издательская компания
2016-01-01
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| Series: | Рациональная фармакотерапия в кардиологии |
| Subjects: | |
| Online Access: | https://www.rpcardio.online/jour/article/view/664 |
| _version_ | 1797232374501605376 |
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| author | A. R. Kiselev V. I. Gridnev A. S. Karavaev O. M. Posnenkova V. A. Shvarts V. I. Ponomarenko M. D. Prokhorov B. P. Bezruchko |
| author_facet | A. R. Kiselev V. I. Gridnev A. S. Karavaev O. M. Posnenkova V. A. Shvarts V. I. Ponomarenko M. D. Prokhorov B. P. Bezruchko |
| author_sort | A. R. Kiselev |
| collection | DOAJ |
| description | Aim. To study effects of carvedilol and metoprolol on vegetative regulation of heart and microcirculatory vessels in patients with arterial hypertension (HT) of 1-2 degrees and high body mass/obesity.Material and methods. Patients with HT of 1-2 degrees (n=25; aged 51±8 y.o.) were included in the study. Registration of 0,1 Hz-fluctuations in heart rhythm variability and microcirculation change was performed during passive orthostatic test at spontaneous breath (duration of each test stage 10 min). Synchronization of 0,1 Hz-rhythms was estimated by calculation of phases difference and a numerical measure of synchronization. Frequency estimations of heart rhythm variability spectrum were performed in high and low frequency ranges additionaly.Results. Carvedilol and metoprolol have the comparable antihypertensive effect and influence on vegetative regulation of cardiovascular system in patients with HT. Both drugs have negative influence on synchronization of 0,1 Hz-rhythms in initially high systolic blood pressure level (>150 mm Hg).Conclusion. Carvedilol and metoprolol have comparable influence on synchronization of 0,1 Hz-rhythms in cardiovascular system. |
| first_indexed | 2024-03-08T14:04:58Z |
| format | Article |
| id | doaj.art-5d9b761211614f7592cc32a6d3a80f63 |
| institution | Directory Open Access Journal |
| issn | 1819-6446 2225-3653 |
| language | English |
| last_indexed | 2024-04-24T15:59:16Z |
| publishDate | 2016-01-01 |
| publisher | Столичная издательская компания |
| record_format | Article |
| series | Рациональная фармакотерапия в кардиологии |
| spelling | doaj.art-5d9b761211614f7592cc32a6d3a80f632024-04-01T07:43:28ZengСтоличная издательская компанияРациональная фармакотерапия в кардиологии1819-64462225-36532016-01-0153556110.20996/1819-6446-2009-5-3-55-61663EFFECTS OF CARVEDILOL AND METOPROLOL ON VEGETATIVE REGULATION OF HEART AND MICROCIRCULATION IN PATIENTS WITH HYPERTENSION AND HIGH BODY MASSA. R. Kiselev0V. I. Gridnev1A. S. Karavaev2O. M. Posnenkova3V. A. Shvarts4V. I. Ponomarenko5M. D. Prokhorov6B. P. Bezruchko7Saratov Research Institute of Cardiology of RosmedtechnologySaratov Research Institute of Cardiology of RosmedtechnologySaratov State University named after N.G. ChernyshevskySaratov Research Institute of Cardiology of RosmedtechnologySaratov Research Institute of Cardiology of RosmedtechnologySaratov Affiliate of Institute of Radiotechnics and Electronics of Russian Academy of ScienceSaratov Affiliate of Institute of Radiotechnics and Electronics of Russian Academy of ScienceSaratov State University named after N.G. ChernyshevskyAim. To study effects of carvedilol and metoprolol on vegetative regulation of heart and microcirculatory vessels in patients with arterial hypertension (HT) of 1-2 degrees and high body mass/obesity.Material and methods. Patients with HT of 1-2 degrees (n=25; aged 51±8 y.o.) were included in the study. Registration of 0,1 Hz-fluctuations in heart rhythm variability and microcirculation change was performed during passive orthostatic test at spontaneous breath (duration of each test stage 10 min). Synchronization of 0,1 Hz-rhythms was estimated by calculation of phases difference and a numerical measure of synchronization. Frequency estimations of heart rhythm variability spectrum were performed in high and low frequency ranges additionaly.Results. Carvedilol and metoprolol have the comparable antihypertensive effect and influence on vegetative regulation of cardiovascular system in patients with HT. Both drugs have negative influence on synchronization of 0,1 Hz-rhythms in initially high systolic blood pressure level (>150 mm Hg).Conclusion. Carvedilol and metoprolol have comparable influence on synchronization of 0,1 Hz-rhythms in cardiovascular system.https://www.rpcardio.online/jour/article/view/664arterial hypertensioncarvedilolmetoprololvegetative regulation |
| spellingShingle | A. R. Kiselev V. I. Gridnev A. S. Karavaev O. M. Posnenkova V. A. Shvarts V. I. Ponomarenko M. D. Prokhorov B. P. Bezruchko EFFECTS OF CARVEDILOL AND METOPROLOL ON VEGETATIVE REGULATION OF HEART AND MICROCIRCULATION IN PATIENTS WITH HYPERTENSION AND HIGH BODY MASS Рациональная фармакотерапия в кардиологии arterial hypertension carvedilol metoprolol vegetative regulation |
| title | EFFECTS OF CARVEDILOL AND METOPROLOL ON VEGETATIVE REGULATION OF HEART AND MICROCIRCULATION IN PATIENTS WITH HYPERTENSION AND HIGH BODY MASS |
| title_full | EFFECTS OF CARVEDILOL AND METOPROLOL ON VEGETATIVE REGULATION OF HEART AND MICROCIRCULATION IN PATIENTS WITH HYPERTENSION AND HIGH BODY MASS |
| title_fullStr | EFFECTS OF CARVEDILOL AND METOPROLOL ON VEGETATIVE REGULATION OF HEART AND MICROCIRCULATION IN PATIENTS WITH HYPERTENSION AND HIGH BODY MASS |
| title_full_unstemmed | EFFECTS OF CARVEDILOL AND METOPROLOL ON VEGETATIVE REGULATION OF HEART AND MICROCIRCULATION IN PATIENTS WITH HYPERTENSION AND HIGH BODY MASS |
| title_short | EFFECTS OF CARVEDILOL AND METOPROLOL ON VEGETATIVE REGULATION OF HEART AND MICROCIRCULATION IN PATIENTS WITH HYPERTENSION AND HIGH BODY MASS |
| title_sort | effects of carvedilol and metoprolol on vegetative regulation of heart and microcirculation in patients with hypertension and high body mass |
| topic | arterial hypertension carvedilol metoprolol vegetative regulation |
| url | https://www.rpcardio.online/jour/article/view/664 |
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