Efficacy and Safety of Third Dose of the COVID-19 Vaccine among Solid Organ Transplant Recipients: A Systemic Review and Meta-Analysis

Solid organ transplant recipients were demonstrated to have reduced antibody response to the first and second doses of the COVID-19 mRNA vaccine. This review evaluated published data on the efficacy and safety of the third dose among solid organ transplant recipients. We performed a systematic searc...

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Main Authors: Orly Efros, Roi Anteby, Mirit Halfon, Eshcar Meisel, Eyal Klang, Shelly Soffer
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Vaccines
Subjects:
Online Access:https://www.mdpi.com/2076-393X/10/1/95
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author Orly Efros
Roi Anteby
Mirit Halfon
Eshcar Meisel
Eyal Klang
Shelly Soffer
author_facet Orly Efros
Roi Anteby
Mirit Halfon
Eshcar Meisel
Eyal Klang
Shelly Soffer
author_sort Orly Efros
collection DOAJ
description Solid organ transplant recipients were demonstrated to have reduced antibody response to the first and second doses of the COVID-19 mRNA vaccine. This review evaluated published data on the efficacy and safety of the third dose among solid organ transplant recipients. We performed a systematic search of PubMed, EMBASE, and Web of Science to retrieve studies evaluating the efficacy of the third dose of anti-SARS-CoV-2 vaccines in adult solid organ transplant recipients. Serologic response after the third vaccine was pooled using inverse variance and generalized linear mixed and random-effects models. Seven studies met our inclusion criteria. A total of 853 patients received the third dose. Except for one randomized controlled trial, all studies were retrospective in design. Following the third COVID-19 vaccine dose, antibody response occurred in 6.4–69.2% of patients. The pooled proportion of antibody response rate after the third vaccine was 50.3% (95% confidence interval (CI): 37.1–63.5, I<sup>2</sup> = 90%). Five papers reported the safety profile. No severe adverse events were observed after the third vaccine dose. In conclusion, a third dose of the SARS-CoV-2 mRNA vaccine in solid organ transplant recipients is associated with improved immunogenicity and appears to be safe. Nevertheless, a significant portion of patients remain seronegative.
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spelling doaj.art-5d9bd8b625e2417897d7d796705b84522023-11-23T15:39:20ZengMDPI AGVaccines2076-393X2022-01-011019510.3390/vaccines10010095Efficacy and Safety of Third Dose of the COVID-19 Vaccine among Solid Organ Transplant Recipients: A Systemic Review and Meta-AnalysisOrly Efros0Roi Anteby1Mirit Halfon2Eshcar Meisel3Eyal Klang4Shelly Soffer5National Hemophilia Center, Thrombosis & Hemostasis Institute, Sheba Medical Center, Ramat-Gan 5262100, IsraelSackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 6997801, IsraelSackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 6997801, IsraelSackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 6997801, IsraelSackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 6997801, IsraelInternal Medicine Department B, Assuta Medical Center, Ben-Gurion University of the Negev, Be’er Sheva 8410501, IsraelSolid organ transplant recipients were demonstrated to have reduced antibody response to the first and second doses of the COVID-19 mRNA vaccine. This review evaluated published data on the efficacy and safety of the third dose among solid organ transplant recipients. We performed a systematic search of PubMed, EMBASE, and Web of Science to retrieve studies evaluating the efficacy of the third dose of anti-SARS-CoV-2 vaccines in adult solid organ transplant recipients. Serologic response after the third vaccine was pooled using inverse variance and generalized linear mixed and random-effects models. Seven studies met our inclusion criteria. A total of 853 patients received the third dose. Except for one randomized controlled trial, all studies were retrospective in design. Following the third COVID-19 vaccine dose, antibody response occurred in 6.4–69.2% of patients. The pooled proportion of antibody response rate after the third vaccine was 50.3% (95% confidence interval (CI): 37.1–63.5, I<sup>2</sup> = 90%). Five papers reported the safety profile. No severe adverse events were observed after the third vaccine dose. In conclusion, a third dose of the SARS-CoV-2 mRNA vaccine in solid organ transplant recipients is associated with improved immunogenicity and appears to be safe. Nevertheless, a significant portion of patients remain seronegative.https://www.mdpi.com/2076-393X/10/1/95COVID-19vaccinesthird dosesolid organ transplant recipients
spellingShingle Orly Efros
Roi Anteby
Mirit Halfon
Eshcar Meisel
Eyal Klang
Shelly Soffer
Efficacy and Safety of Third Dose of the COVID-19 Vaccine among Solid Organ Transplant Recipients: A Systemic Review and Meta-Analysis
Vaccines
COVID-19
vaccines
third dose
solid organ transplant recipients
title Efficacy and Safety of Third Dose of the COVID-19 Vaccine among Solid Organ Transplant Recipients: A Systemic Review and Meta-Analysis
title_full Efficacy and Safety of Third Dose of the COVID-19 Vaccine among Solid Organ Transplant Recipients: A Systemic Review and Meta-Analysis
title_fullStr Efficacy and Safety of Third Dose of the COVID-19 Vaccine among Solid Organ Transplant Recipients: A Systemic Review and Meta-Analysis
title_full_unstemmed Efficacy and Safety of Third Dose of the COVID-19 Vaccine among Solid Organ Transplant Recipients: A Systemic Review and Meta-Analysis
title_short Efficacy and Safety of Third Dose of the COVID-19 Vaccine among Solid Organ Transplant Recipients: A Systemic Review and Meta-Analysis
title_sort efficacy and safety of third dose of the covid 19 vaccine among solid organ transplant recipients a systemic review and meta analysis
topic COVID-19
vaccines
third dose
solid organ transplant recipients
url https://www.mdpi.com/2076-393X/10/1/95
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