Prospective Clinical Study of Non-Invasive Intracranial Pressure Measurements in Open-Angle Glaucoma Patients and Healthy Subjects
<i>Background and Objective:</i> Glaucoma is a progressive optic neuropathy in which the optic nerve is damaged. The optic nerve is exposed not only to intraocular pressure (IOP) in the eye, but also to intracranial pressure (ICP), as it is surrounded by cerebrospinal fluid in the subara...
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| Format: | Article |
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MDPI AG
2020-11-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1010-660X/56/12/664 |
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| author | Mantas Deimantavicius Yasin Hamarat Paulius Lucinskas Rolandas Zakelis Laimonas Bartusis Lina Siaudvytyte Ingrida Janulevicienė Arminas Ragauskas |
| author_facet | Mantas Deimantavicius Yasin Hamarat Paulius Lucinskas Rolandas Zakelis Laimonas Bartusis Lina Siaudvytyte Ingrida Janulevicienė Arminas Ragauskas |
| author_sort | Mantas Deimantavicius |
| collection | DOAJ |
| description | <i>Background and Objective:</i> Glaucoma is a progressive optic neuropathy in which the optic nerve is damaged. The optic nerve is exposed not only to intraocular pressure (IOP) in the eye, but also to intracranial pressure (ICP), as it is surrounded by cerebrospinal fluid in the subarachnoid space. Here, we analyse ICP differences between patients with glaucoma and healthy subjects (HSs). <i>Materials and Methods:</i> Ninety-five patients with normal-tension glaucoma (NTG), 60 patients with high-tension glaucoma (HTG), and 62 HSs were included in the prospective clinical study, and ICP was measured non-invasively by two-depth transcranial Doppler (TCD). <i>Results:</i> The mean ICP of NTG patients (9.42 ± 2.83 mmHg) was significantly lower than that of HSs (10.73 ± 2.16 mmHg) (<i>p</i> = 0.007). The mean ICP of HTG patients (8.11 ± 2.68 mmHg) was significantly lower than that of NTG patients (9.42 ± 2.83 mmHg) (<i>p</i> = 0.008) and significantly lower than that of HSs (10.73 ± 2.16 mmHg) (<i>p</i> < 0.001). <i>Conclusions:</i> An abnormal ICP value could be one of the many influential factors in the optic nerve degeneration of NTG patients and should be considered as such instead of just being regarded as a “low ICP”. |
| first_indexed | 2024-03-12T11:13:34Z |
| format | Article |
| id | doaj.art-5d9d2fd991f64b04a92ecbbb4c14c62e |
| institution | Directory Open Access Journal |
| issn | 1010-660X |
| language | English |
| last_indexed | 2024-03-12T11:13:34Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-5d9d2fd991f64b04a92ecbbb4c14c62e2023-09-02T02:28:41ZengMDPI AGMedicina1010-660X2020-11-015666466410.3390/medicina56120664Prospective Clinical Study of Non-Invasive Intracranial Pressure Measurements in Open-Angle Glaucoma Patients and Healthy SubjectsMantas Deimantavicius0Yasin Hamarat1Paulius Lucinskas2Rolandas Zakelis3Laimonas Bartusis4Lina Siaudvytyte5Ingrida Janulevicienė6Arminas Ragauskas7Health Telematics Science Institute, Kaunas University of Technology, 51423 Kaunas, LithuaniaHealth Telematics Science Institute, Kaunas University of Technology, 51423 Kaunas, LithuaniaHealth Telematics Science Institute, Kaunas University of Technology, 51423 Kaunas, LithuaniaHealth Telematics Science Institute, Kaunas University of Technology, 51423 Kaunas, LithuaniaHealth Telematics Science Institute, Kaunas University of Technology, 51423 Kaunas, LithuaniaEye Clinic, Lithuanian University of Health Sciences, 50161 Kaunas, LithuaniaEye Clinic, Lithuanian University of Health Sciences, 50161 Kaunas, LithuaniaHealth Telematics Science Institute, Kaunas University of Technology, 51423 Kaunas, Lithuania<i>Background and Objective:</i> Glaucoma is a progressive optic neuropathy in which the optic nerve is damaged. The optic nerve is exposed not only to intraocular pressure (IOP) in the eye, but also to intracranial pressure (ICP), as it is surrounded by cerebrospinal fluid in the subarachnoid space. Here, we analyse ICP differences between patients with glaucoma and healthy subjects (HSs). <i>Materials and Methods:</i> Ninety-five patients with normal-tension glaucoma (NTG), 60 patients with high-tension glaucoma (HTG), and 62 HSs were included in the prospective clinical study, and ICP was measured non-invasively by two-depth transcranial Doppler (TCD). <i>Results:</i> The mean ICP of NTG patients (9.42 ± 2.83 mmHg) was significantly lower than that of HSs (10.73 ± 2.16 mmHg) (<i>p</i> = 0.007). The mean ICP of HTG patients (8.11 ± 2.68 mmHg) was significantly lower than that of NTG patients (9.42 ± 2.83 mmHg) (<i>p</i> = 0.008) and significantly lower than that of HSs (10.73 ± 2.16 mmHg) (<i>p</i> < 0.001). <i>Conclusions:</i> An abnormal ICP value could be one of the many influential factors in the optic nerve degeneration of NTG patients and should be considered as such instead of just being regarded as a “low ICP”.https://www.mdpi.com/1010-660X/56/12/664primary open angle glaucomanormal-tension glaucomahigh-tension glaucomaintracranial pressurenon-invasive ICP measurement |
| spellingShingle | Mantas Deimantavicius Yasin Hamarat Paulius Lucinskas Rolandas Zakelis Laimonas Bartusis Lina Siaudvytyte Ingrida Janulevicienė Arminas Ragauskas Prospective Clinical Study of Non-Invasive Intracranial Pressure Measurements in Open-Angle Glaucoma Patients and Healthy Subjects Medicina primary open angle glaucoma normal-tension glaucoma high-tension glaucoma intracranial pressure non-invasive ICP measurement |
| title | Prospective Clinical Study of Non-Invasive Intracranial Pressure Measurements in Open-Angle Glaucoma Patients and Healthy Subjects |
| title_full | Prospective Clinical Study of Non-Invasive Intracranial Pressure Measurements in Open-Angle Glaucoma Patients and Healthy Subjects |
| title_fullStr | Prospective Clinical Study of Non-Invasive Intracranial Pressure Measurements in Open-Angle Glaucoma Patients and Healthy Subjects |
| title_full_unstemmed | Prospective Clinical Study of Non-Invasive Intracranial Pressure Measurements in Open-Angle Glaucoma Patients and Healthy Subjects |
| title_short | Prospective Clinical Study of Non-Invasive Intracranial Pressure Measurements in Open-Angle Glaucoma Patients and Healthy Subjects |
| title_sort | prospective clinical study of non invasive intracranial pressure measurements in open angle glaucoma patients and healthy subjects |
| topic | primary open angle glaucoma normal-tension glaucoma high-tension glaucoma intracranial pressure non-invasive ICP measurement |
| url | https://www.mdpi.com/1010-660X/56/12/664 |
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