Biomedical applications of stimuli-responsive “smart” interpenetrating polymer network hydrogels
In recent years, owing to the ongoing advancements in polymer materials, hydrogels have found increasing applications in the biomedical domain, notably in the realm of stimuli-responsive ''smart'' hydrogels. Nonetheless, conventional single-network stimuli-responsive ''...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-04-01
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| Series: | Materials Today Bio |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006424000577 |
| _version_ | 1797258657799340032 |
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| author | Jiuping Wu Wu Xue Zhihe Yun Qinyi Liu Xinzhi Sun |
| author_facet | Jiuping Wu Wu Xue Zhihe Yun Qinyi Liu Xinzhi Sun |
| author_sort | Jiuping Wu |
| collection | DOAJ |
| description | In recent years, owing to the ongoing advancements in polymer materials, hydrogels have found increasing applications in the biomedical domain, notably in the realm of stimuli-responsive ''smart'' hydrogels. Nonetheless, conventional single-network stimuli-responsive ''smart'' hydrogels frequently exhibit deficiencies, including low mechanical strength, limited biocompatibility, and extended response times. In response, researchers have addressed these challenges by introducing a second network to create stimuli-responsive ''smart'' Interpenetrating Polymer Network (IPN) hydrogels. The mechanical strength of the material can be significantly improved due to the topological entanglement and physical interactions within the interpenetrating structure. Simultaneously, combining different network structures enhances the biocompatibility and stimulus responsiveness of the gel, endowing it with unique properties such as cell adhesion, conductivity, hemostasis/antioxidation, and color-changing capabilities. This article primarily aims to elucidate the stimulus-inducing factors in stimuli-responsive ''smart'' IPN hydrogels, the impact of the gels on cell behaviors and their biomedical application range. Additionally, we also offer an in-depth exposition of their categorization, mechanisms, performance characteristics, and related aspects. This review furnishes a comprehensive assessment and outlook for the advancement of stimuli-responsive ''smart'' IPN hydrogels within the biomedical arena. We believe that, as the biomedical field increasingly demands novel materials featuring improved mechanical properties, robust biocompatibility, and heightened stimulus responsiveness, stimuli-responsive ''smart'' IPN hydrogels will hold substantial promise for wide-ranging applications in this domain. |
| first_indexed | 2024-03-08T00:09:07Z |
| format | Article |
| id | doaj.art-5d9ebc1ebbfe47fc8a433194de734fae |
| institution | Directory Open Access Journal |
| issn | 2590-0064 |
| language | English |
| last_indexed | 2024-04-24T22:57:01Z |
| publishDate | 2024-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj.art-5d9ebc1ebbfe47fc8a433194de734fae2024-03-18T04:34:23ZengElsevierMaterials Today Bio2590-00642024-04-0125100998Biomedical applications of stimuli-responsive “smart” interpenetrating polymer network hydrogelsJiuping Wu0Wu Xue1Zhihe Yun2Qinyi Liu3Xinzhi Sun4Department of Orthopedics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, ChinaDepartment of Orthopedics, The Second Hospital of Jilin University, Changchun, 130041, ChinaDepartment of Orthopedics, The Second Hospital of Jilin University, Changchun, 130041, ChinaDepartment of Orthopedics, The Second Hospital of Jilin University, Changchun, 130041, China; Corresponding author.Department of Orthopedics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China; Corresponding author.In recent years, owing to the ongoing advancements in polymer materials, hydrogels have found increasing applications in the biomedical domain, notably in the realm of stimuli-responsive ''smart'' hydrogels. Nonetheless, conventional single-network stimuli-responsive ''smart'' hydrogels frequently exhibit deficiencies, including low mechanical strength, limited biocompatibility, and extended response times. In response, researchers have addressed these challenges by introducing a second network to create stimuli-responsive ''smart'' Interpenetrating Polymer Network (IPN) hydrogels. The mechanical strength of the material can be significantly improved due to the topological entanglement and physical interactions within the interpenetrating structure. Simultaneously, combining different network structures enhances the biocompatibility and stimulus responsiveness of the gel, endowing it with unique properties such as cell adhesion, conductivity, hemostasis/antioxidation, and color-changing capabilities. This article primarily aims to elucidate the stimulus-inducing factors in stimuli-responsive ''smart'' IPN hydrogels, the impact of the gels on cell behaviors and their biomedical application range. Additionally, we also offer an in-depth exposition of their categorization, mechanisms, performance characteristics, and related aspects. This review furnishes a comprehensive assessment and outlook for the advancement of stimuli-responsive ''smart'' IPN hydrogels within the biomedical arena. We believe that, as the biomedical field increasingly demands novel materials featuring improved mechanical properties, robust biocompatibility, and heightened stimulus responsiveness, stimuli-responsive ''smart'' IPN hydrogels will hold substantial promise for wide-ranging applications in this domain.http://www.sciencedirect.com/science/article/pii/S2590006424000577Stimuli-responsiveSmart hydrogelInterpenetrating polymer networkDual networkBiomedical application |
| spellingShingle | Jiuping Wu Wu Xue Zhihe Yun Qinyi Liu Xinzhi Sun Biomedical applications of stimuli-responsive “smart” interpenetrating polymer network hydrogels Materials Today Bio Stimuli-responsive Smart hydrogel Interpenetrating polymer network Dual network Biomedical application |
| title | Biomedical applications of stimuli-responsive “smart” interpenetrating polymer network hydrogels |
| title_full | Biomedical applications of stimuli-responsive “smart” interpenetrating polymer network hydrogels |
| title_fullStr | Biomedical applications of stimuli-responsive “smart” interpenetrating polymer network hydrogels |
| title_full_unstemmed | Biomedical applications of stimuli-responsive “smart” interpenetrating polymer network hydrogels |
| title_short | Biomedical applications of stimuli-responsive “smart” interpenetrating polymer network hydrogels |
| title_sort | biomedical applications of stimuli responsive smart interpenetrating polymer network hydrogels |
| topic | Stimuli-responsive Smart hydrogel Interpenetrating polymer network Dual network Biomedical application |
| url | http://www.sciencedirect.com/science/article/pii/S2590006424000577 |
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