Non-coding RNAs and chromatin: key epigenetic factors from spermatogenesis to transgenerational inheritance
Abstract Cellular fate and gene expression patterns are modulated by different epigenetic factors including non-coding RNAs (ncRNAs) and chromatin organization. Both factors are dynamic throughout male germ cell differentiation on the seminiferous tubule, despite the transcriptional inactivation in...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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BMC
2021-12-01
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| Series: | Biological Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40659-021-00364-0 |
| _version_ | 1818988375702503424 |
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| author | Carolina Cheuquemán Rodrigo Maldonado |
| author_facet | Carolina Cheuquemán Rodrigo Maldonado |
| author_sort | Carolina Cheuquemán |
| collection | DOAJ |
| description | Abstract Cellular fate and gene expression patterns are modulated by different epigenetic factors including non-coding RNAs (ncRNAs) and chromatin organization. Both factors are dynamic throughout male germ cell differentiation on the seminiferous tubule, despite the transcriptional inactivation in the last stages of spermatogenesis. Sperm maturation during the caput-to-cauda transit on the epididymis involves changes in chromatin organization and the soma-to-germ line transference of ncRNAs that are essential to obtain a functional sperm for fertilization and embryo development. Here, the male environment (diseases, drugs, mental stress) is crucial to modulate these epigenetic factors throughout sperm maturation, affecting the corresponding offspring. Paternal transgenerational inheritance has been directly related to sperm epigenetic changes, most of them associated with variations in the ncRNA content and chromatin marks. Our aim is to give an overview about how epigenetics, focused on ncRNAs and chromatin, is pivotal to understand spermatogenesis and sperm maturation, and how the male environment impacts the sperm epigenome modulating the offspring gene expression pattern. |
| first_indexed | 2024-12-20T19:21:35Z |
| format | Article |
| id | doaj.art-5da0265774ec432880153b5c5a8e4d10 |
| institution | Directory Open Access Journal |
| issn | 0717-6287 |
| language | English |
| last_indexed | 2024-12-20T19:21:35Z |
| publishDate | 2021-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Biological Research |
| spelling | doaj.art-5da0265774ec432880153b5c5a8e4d102022-12-21T19:28:59ZengBMCBiological Research0717-62872021-12-0154111310.1186/s40659-021-00364-0Non-coding RNAs and chromatin: key epigenetic factors from spermatogenesis to transgenerational inheritanceCarolina Cheuquemán0Rodrigo Maldonado1Núcleo de Ciencias Biológicas, Dirección de Núcleos Transversales, Facultad de estudios Interdisciplinarios, Universidad MayorInstitute of Anatomy, Histology and Pathology, Faculty of Medicine, Universidad Austral de ChileAbstract Cellular fate and gene expression patterns are modulated by different epigenetic factors including non-coding RNAs (ncRNAs) and chromatin organization. Both factors are dynamic throughout male germ cell differentiation on the seminiferous tubule, despite the transcriptional inactivation in the last stages of spermatogenesis. Sperm maturation during the caput-to-cauda transit on the epididymis involves changes in chromatin organization and the soma-to-germ line transference of ncRNAs that are essential to obtain a functional sperm for fertilization and embryo development. Here, the male environment (diseases, drugs, mental stress) is crucial to modulate these epigenetic factors throughout sperm maturation, affecting the corresponding offspring. Paternal transgenerational inheritance has been directly related to sperm epigenetic changes, most of them associated with variations in the ncRNA content and chromatin marks. Our aim is to give an overview about how epigenetics, focused on ncRNAs and chromatin, is pivotal to understand spermatogenesis and sperm maturation, and how the male environment impacts the sperm epigenome modulating the offspring gene expression pattern.https://doi.org/10.1186/s40659-021-00364-0Epigenetic inheritanceChromatinMethylationEpigenomeEmbryonic developmentOffspring |
| spellingShingle | Carolina Cheuquemán Rodrigo Maldonado Non-coding RNAs and chromatin: key epigenetic factors from spermatogenesis to transgenerational inheritance Biological Research Epigenetic inheritance Chromatin Methylation Epigenome Embryonic development Offspring |
| title | Non-coding RNAs and chromatin: key epigenetic factors from spermatogenesis to transgenerational inheritance |
| title_full | Non-coding RNAs and chromatin: key epigenetic factors from spermatogenesis to transgenerational inheritance |
| title_fullStr | Non-coding RNAs and chromatin: key epigenetic factors from spermatogenesis to transgenerational inheritance |
| title_full_unstemmed | Non-coding RNAs and chromatin: key epigenetic factors from spermatogenesis to transgenerational inheritance |
| title_short | Non-coding RNAs and chromatin: key epigenetic factors from spermatogenesis to transgenerational inheritance |
| title_sort | non coding rnas and chromatin key epigenetic factors from spermatogenesis to transgenerational inheritance |
| topic | Epigenetic inheritance Chromatin Methylation Epigenome Embryonic development Offspring |
| url | https://doi.org/10.1186/s40659-021-00364-0 |
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