Host biomarkers are associated with progression to dengue haemorrhagic fever: a nested case-control study
Objectives: Dengue represents the most important arboviral infection worldwide. Onset of circulatory collapse can be unpredictable. Biomarkers that can identify individuals at risk of plasma leakage may facilitate better triage and clinical management. Design: Using a nested case-control design, we...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2015-11-01
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| Series: | International Journal of Infectious Diseases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971215001952 |
| _version_ | 1818607744952827904 |
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| author | Andrea L. Conroy Margarita Gélvez Michael Hawkes Nimerta Rajwans Vanessa Tran W. Conrad Liles Luis Angel Villar-Centeno Kevin C. Kain |
| author_facet | Andrea L. Conroy Margarita Gélvez Michael Hawkes Nimerta Rajwans Vanessa Tran W. Conrad Liles Luis Angel Villar-Centeno Kevin C. Kain |
| author_sort | Andrea L. Conroy |
| collection | DOAJ |
| description | Objectives: Dengue represents the most important arboviral infection worldwide. Onset of circulatory collapse can be unpredictable. Biomarkers that can identify individuals at risk of plasma leakage may facilitate better triage and clinical management.
Design: Using a nested case-control design, we randomly selected subjects from a prospective cohort study of dengue in Colombia (n = 1582). Using serum collected within 96 hours of fever onset, we tested 19 biomarkers by ELISA in cases (developed dengue hemorrhagic fever or dengue shock syndrome (DHF/DSS); n = 46), and controls (uncomplicated dengue fever (DF); n = 65) and healthy controls (HC); n = 15.
Results: Ang-1 levels were lower and angptl3, sKDR, sEng, sICAM-1, CRP, CXCL10/IP-10, IL-18 binding protein, CHI3L1, C5a and Factor D levels were increased in dengue compared to HC. sICAM-1, sEng and CXCL10/IP-10 were further elevated in subjects who subsequently developed DHF/DSS (p = 0.008, p = 0.028 and p = 0.025, respectively). In a logistic regression model, age (odds ratio (OR) (95% CI): 0.95 (0.92-0.98), p = 0.001), hyperesthesia/hyperalgesia (OR; 3.8 (1.4-10.4), p = 0.008) and elevated sICAM-1 (>298ng/mL: OR; 6.3 (1.5-25.7), p = 0.011) at presentation were independently associated with progression to DHF/DSS.
Conclusions: These results suggest that inflammation and endothelial activation are important pathways in the pathogenesis of dengue and sICAM-1 levels may identify individuals at risk of plasma leakage. |
| first_indexed | 2024-12-16T14:31:37Z |
| format | Article |
| id | doaj.art-5da02d1038864c19a0af7e223d26e325 |
| institution | Directory Open Access Journal |
| issn | 1201-9712 1878-3511 |
| language | English |
| last_indexed | 2024-12-16T14:31:37Z |
| publishDate | 2015-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj.art-5da02d1038864c19a0af7e223d26e3252022-12-21T22:28:13ZengElsevierInternational Journal of Infectious Diseases1201-97121878-35112015-11-0140C455310.1016/j.ijid.2015.07.027Host biomarkers are associated with progression to dengue haemorrhagic fever: a nested case-control studyAndrea L. Conroy0Margarita Gélvez1Michael Hawkes2Nimerta Rajwans3Vanessa Tran4W. Conrad Liles5Luis Angel Villar-Centeno6Kevin C. Kain7Sandra A. Rotman Laboratories, Sandra Rotman Centre, University Health Network-Toronto General Hospital, University of Toronto, Toronto, ON, M5G 1L7, CanadaCentro de Investigaciones Epidemiológicas, Facultad de Salud, Universidad Industrial de Santander, Bucaramanga, ColombiaDepartment of Pediatrics, University of Alberta, Edmonton, AB, T6G 2E1, CanadaSandra A. Rotman Laboratories, Sandra Rotman Centre, University Health Network-Toronto General Hospital, University of Toronto, Toronto, ON, M5G 1L7, CanadaSandra A. Rotman Laboratories, Sandra Rotman Centre, University Health Network-Toronto General Hospital, University of Toronto, Toronto, ON, M5G 1L7, CanadaUniversity of Washington, Department of Medicine, Seattle, WA, 98195, USACentro de Investigaciones Epidemiológicas, Facultad de Salud, Universidad Industrial de Santander, Bucaramanga, ColombiaSandra A. Rotman Laboratories, Sandra Rotman Centre, University Health Network-Toronto General Hospital, University of Toronto, Toronto, ON, M5G 1L7, CanadaObjectives: Dengue represents the most important arboviral infection worldwide. Onset of circulatory collapse can be unpredictable. Biomarkers that can identify individuals at risk of plasma leakage may facilitate better triage and clinical management. Design: Using a nested case-control design, we randomly selected subjects from a prospective cohort study of dengue in Colombia (n = 1582). Using serum collected within 96 hours of fever onset, we tested 19 biomarkers by ELISA in cases (developed dengue hemorrhagic fever or dengue shock syndrome (DHF/DSS); n = 46), and controls (uncomplicated dengue fever (DF); n = 65) and healthy controls (HC); n = 15. Results: Ang-1 levels were lower and angptl3, sKDR, sEng, sICAM-1, CRP, CXCL10/IP-10, IL-18 binding protein, CHI3L1, C5a and Factor D levels were increased in dengue compared to HC. sICAM-1, sEng and CXCL10/IP-10 were further elevated in subjects who subsequently developed DHF/DSS (p = 0.008, p = 0.028 and p = 0.025, respectively). In a logistic regression model, age (odds ratio (OR) (95% CI): 0.95 (0.92-0.98), p = 0.001), hyperesthesia/hyperalgesia (OR; 3.8 (1.4-10.4), p = 0.008) and elevated sICAM-1 (>298ng/mL: OR; 6.3 (1.5-25.7), p = 0.011) at presentation were independently associated with progression to DHF/DSS. Conclusions: These results suggest that inflammation and endothelial activation are important pathways in the pathogenesis of dengue and sICAM-1 levels may identify individuals at risk of plasma leakage.http://www.sciencedirect.com/science/article/pii/S1201971215001952denguebiomarkerspathogenesissICAM-1soluble endoglinCXCL10 |
| spellingShingle | Andrea L. Conroy Margarita Gélvez Michael Hawkes Nimerta Rajwans Vanessa Tran W. Conrad Liles Luis Angel Villar-Centeno Kevin C. Kain Host biomarkers are associated with progression to dengue haemorrhagic fever: a nested case-control study International Journal of Infectious Diseases dengue biomarkers pathogenesis sICAM-1 soluble endoglin CXCL10 |
| title | Host biomarkers are associated with progression to dengue haemorrhagic fever: a nested case-control study |
| title_full | Host biomarkers are associated with progression to dengue haemorrhagic fever: a nested case-control study |
| title_fullStr | Host biomarkers are associated with progression to dengue haemorrhagic fever: a nested case-control study |
| title_full_unstemmed | Host biomarkers are associated with progression to dengue haemorrhagic fever: a nested case-control study |
| title_short | Host biomarkers are associated with progression to dengue haemorrhagic fever: a nested case-control study |
| title_sort | host biomarkers are associated with progression to dengue haemorrhagic fever a nested case control study |
| topic | dengue biomarkers pathogenesis sICAM-1 soluble endoglin CXCL10 |
| url | http://www.sciencedirect.com/science/article/pii/S1201971215001952 |
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