Down-Regulation of Colonic ACE2 Expression in Patients With Inflammatory Bowel Disease Responding to Anti-TNF Therapy: Implications for COVID-19

Down-Regulation of Colonic ACE2 Expression in Patients With Inflammatory Bowel Disease Responding to Anti-TNF Therapy: Implications for COVID-19

Background and Aims: Angiotensin-converting enzyme II (ACE2) is the key molecule for understanding the pathophysiology of COVID-19. The risk of COVID-19 and impact of immunosuppressive treatment on disease course in patients with inflammatory bowel disease (IBD) remain controversial. We aimed to det...

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Bibliographic Details
Main Authors: Xiao-Zhi Li, Yun Qiu, Louisa Jeffery, Fen Liu, Rui Feng, Jin-Shen He, Jin-Yu Tan, Zi-Yin Ye, Si-Nan Lin, Subrata Ghosh, Marietta Iacucci, Min-Hu Chen, Ren Mao
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Medicine
Subjects:
COVID-19
ACE2
inflammatory bowel disease
intestine
anti-TNFα
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2020.613475/full

Internet

https://www.frontiersin.org/articles/10.3389/fmed.2020.613475/full

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