Regulation of tumor angiogenesis by the crosstalk between innate immunity and endothelial cells
Endothelial cells and immune cells are major regulators of cancer progression and prognosis. Endothelial cell proliferation and angiogenesis are required for providing nutrients and oxygen to the nascent tumor and infiltration of immune cells to the tumor is dependent on endothelial cell activation....
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-05-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1171794/full |
| _version_ | 1827950623574720512 |
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| author | Svenja Ebeling Svenja Ebeling Anita Kowalczyk Anita Kowalczyk Diego Perez-Vazquez Diego Perez-Vazquez Irene Mattiola Irene Mattiola |
| author_facet | Svenja Ebeling Svenja Ebeling Anita Kowalczyk Anita Kowalczyk Diego Perez-Vazquez Diego Perez-Vazquez Irene Mattiola Irene Mattiola |
| author_sort | Svenja Ebeling |
| collection | DOAJ |
| description | Endothelial cells and immune cells are major regulators of cancer progression and prognosis. Endothelial cell proliferation and angiogenesis are required for providing nutrients and oxygen to the nascent tumor and infiltration of immune cells to the tumor is dependent on endothelial cell activation. Myeloid cells and innate lymphocytes have an important role in shaping the tumor microenvironment by crosstalking with cancer cells and structural cells, including endothelial cells. Innate immune cells can modulate the activation and functions of tumor endothelial cells, and, in turn, endothelial cell expression of adhesion molecules can affect immune cell extravasation. However, the mechanisms underlying this bidirectional crosstalk are not fully understood. In this review, we will provide an overview of the current knowledge on the pathways regulating the crosstalk between innate immune cells and endothelial cells during tumor progression and discuss their potential contribution to the development of novel anti-tumor therapeutic approaches. |
| first_indexed | 2024-04-09T13:29:34Z |
| format | Article |
| id | doaj.art-5da2c2602ecc447eadd86414af40770c |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-09T13:29:34Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-5da2c2602ecc447eadd86414af40770c2023-05-10T05:00:26ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-05-011310.3389/fonc.2023.11717941171794Regulation of tumor angiogenesis by the crosstalk between innate immunity and endothelial cellsSvenja Ebeling0Svenja Ebeling1Anita Kowalczyk2Anita Kowalczyk3Diego Perez-Vazquez4Diego Perez-Vazquez5Irene Mattiola6Irene Mattiola7Institute of Microbiology, Infectious Diseases and Immunology (I-MIDI), Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and the Berlin Institute of Health, Berlin, GermanyLaboratory of Mucosal and Developmental Immunology, Deutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz Association, Berlin, GermanyInstitute of Microbiology, Infectious Diseases and Immunology (I-MIDI), Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and the Berlin Institute of Health, Berlin, GermanyLaboratory of Mucosal and Developmental Immunology, Deutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz Association, Berlin, GermanyInstitute of Microbiology, Infectious Diseases and Immunology (I-MIDI), Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and the Berlin Institute of Health, Berlin, GermanyLaboratory of Mucosal and Developmental Immunology, Deutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz Association, Berlin, GermanyInstitute of Microbiology, Infectious Diseases and Immunology (I-MIDI), Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and the Berlin Institute of Health, Berlin, GermanyLaboratory of Mucosal and Developmental Immunology, Deutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz Association, Berlin, GermanyEndothelial cells and immune cells are major regulators of cancer progression and prognosis. Endothelial cell proliferation and angiogenesis are required for providing nutrients and oxygen to the nascent tumor and infiltration of immune cells to the tumor is dependent on endothelial cell activation. Myeloid cells and innate lymphocytes have an important role in shaping the tumor microenvironment by crosstalking with cancer cells and structural cells, including endothelial cells. Innate immune cells can modulate the activation and functions of tumor endothelial cells, and, in turn, endothelial cell expression of adhesion molecules can affect immune cell extravasation. However, the mechanisms underlying this bidirectional crosstalk are not fully understood. In this review, we will provide an overview of the current knowledge on the pathways regulating the crosstalk between innate immune cells and endothelial cells during tumor progression and discuss their potential contribution to the development of novel anti-tumor therapeutic approaches.https://www.frontiersin.org/articles/10.3389/fonc.2023.1171794/fullmyeloid cellsinnate lymphocytesendothelial cellscancerangiogenesis |
| spellingShingle | Svenja Ebeling Svenja Ebeling Anita Kowalczyk Anita Kowalczyk Diego Perez-Vazquez Diego Perez-Vazquez Irene Mattiola Irene Mattiola Regulation of tumor angiogenesis by the crosstalk between innate immunity and endothelial cells Frontiers in Oncology myeloid cells innate lymphocytes endothelial cells cancer angiogenesis |
| title | Regulation of tumor angiogenesis by the crosstalk between innate immunity and endothelial cells |
| title_full | Regulation of tumor angiogenesis by the crosstalk between innate immunity and endothelial cells |
| title_fullStr | Regulation of tumor angiogenesis by the crosstalk between innate immunity and endothelial cells |
| title_full_unstemmed | Regulation of tumor angiogenesis by the crosstalk between innate immunity and endothelial cells |
| title_short | Regulation of tumor angiogenesis by the crosstalk between innate immunity and endothelial cells |
| title_sort | regulation of tumor angiogenesis by the crosstalk between innate immunity and endothelial cells |
| topic | myeloid cells innate lymphocytes endothelial cells cancer angiogenesis |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1171794/full |
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