The predominant role of 18F-FDG PET/CT over MDCT in assessment of ovarian cancer patient
Objectives: This article discusses that FDG PET/CT is superior to MDCT in evaluation of ovarian cancer oncological evaluation. Patients and methods: 87 PET/CT scans of 64 women with clinically suspected or pathologically proven ovarian cancer were retrospectively analyzed. The findings of contrast e...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2015-12-01
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| Series: | The Egyptian Journal of Radiology and Nuclear Medicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0378603X15001771 |
| _version_ | 1818229178463420416 |
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| author | Hemat A. Mahmoud Haisam Atta Waleed A. Diab Lamiaa M. Eloteify Hisham Imam Adel Gabr Mohamed A. Mekkawy Waleed M. Omar |
| author_facet | Hemat A. Mahmoud Haisam Atta Waleed A. Diab Lamiaa M. Eloteify Hisham Imam Adel Gabr Mohamed A. Mekkawy Waleed M. Omar |
| author_sort | Hemat A. Mahmoud |
| collection | DOAJ |
| description | Objectives: This article discusses that FDG PET/CT is superior to MDCT in evaluation of ovarian cancer oncological evaluation.
Patients and methods: 87 PET/CT scans of 64 women with clinically suspected or pathologically proven ovarian cancer were retrospectively analyzed. The findings of contrast enhanced MDCT (CE-CT) were interpreted by two experienced radiologists unaware of PET/CT findings. At least two experienced nuclear medicine physicians who were unaware of CE-MDCT findings examined PET images, evaluating localization and characterization and comparing them to co-registered PET/CT images. Diagnostic accuracy was determined on a patient level and a region level.
Results: PET has significantly higher Sensitivity, specificity, PPV, NPV, and overall accuracy of 94.7%, 86.7%, 93.1%, 89.7%, and 91.9% respectively compared to 89.5%, 30%, 70.8%, 60% and 68.9% for MDCT on patient level. The diagnostic performance of PET was also better at most anatomical sites when results were analyzed on region level.
Conclusions and recommendations: FDG PET in addition to conventional imaging modalities should represent an important step in the diagnostic flowchart of ovarian cancer patients for evaluating abdominal and extra-abdominal probable metastatic deposits. |
| first_indexed | 2024-12-12T10:14:28Z |
| format | Article |
| id | doaj.art-5da2e40536a941819d23c01feafbf66f |
| institution | Directory Open Access Journal |
| issn | 0378-603X |
| language | English |
| last_indexed | 2024-12-12T10:14:28Z |
| publishDate | 2015-12-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Radiology and Nuclear Medicine |
| spelling | doaj.art-5da2e40536a941819d23c01feafbf66f2022-12-22T00:27:42ZengSpringerOpenThe Egyptian Journal of Radiology and Nuclear Medicine0378-603X2015-12-014641313132210.1016/j.ejrnm.2015.07.011The predominant role of 18F-FDG PET/CT over MDCT in assessment of ovarian cancer patientHemat A. Mahmoud0Haisam Atta1Waleed A. Diab2Lamiaa M. Eloteify3Hisham Imam4Adel Gabr5Mohamed A. Mekkawy6Waleed M. Omar7Department of Clinical Oncology and Nuclear Medicine, Assiut University Hospital, EgyptDepartment of Radiology, South Egypt Cancer Institute, Assiut University, EgyptDepartment of Clinical Oncology and Nuclear Medicine, Assiut University Hospital, EgyptDepartment of Clinical Oncology and Nuclear Medicine, Assiut University Hospital, EgyptDepartment of Radiology, Assiut University Hospital, EgyptDepartment of Medical Oncology, South Egypt Cancer Institute, Assiut University, EgyptDepartment of Clinical Oncology and Nuclear Medicine, Assiut University Hospital, EgyptDepartment of Nuclear Medicine, National Cancer Institute, Cairo University, EgyptObjectives: This article discusses that FDG PET/CT is superior to MDCT in evaluation of ovarian cancer oncological evaluation. Patients and methods: 87 PET/CT scans of 64 women with clinically suspected or pathologically proven ovarian cancer were retrospectively analyzed. The findings of contrast enhanced MDCT (CE-CT) were interpreted by two experienced radiologists unaware of PET/CT findings. At least two experienced nuclear medicine physicians who were unaware of CE-MDCT findings examined PET images, evaluating localization and characterization and comparing them to co-registered PET/CT images. Diagnostic accuracy was determined on a patient level and a region level. Results: PET has significantly higher Sensitivity, specificity, PPV, NPV, and overall accuracy of 94.7%, 86.7%, 93.1%, 89.7%, and 91.9% respectively compared to 89.5%, 30%, 70.8%, 60% and 68.9% for MDCT on patient level. The diagnostic performance of PET was also better at most anatomical sites when results were analyzed on region level. Conclusions and recommendations: FDG PET in addition to conventional imaging modalities should represent an important step in the diagnostic flowchart of ovarian cancer patients for evaluating abdominal and extra-abdominal probable metastatic deposits.http://www.sciencedirect.com/science/article/pii/S0378603X15001771FDG PET/CTMDCTOvarian cancer |
| spellingShingle | Hemat A. Mahmoud Haisam Atta Waleed A. Diab Lamiaa M. Eloteify Hisham Imam Adel Gabr Mohamed A. Mekkawy Waleed M. Omar The predominant role of 18F-FDG PET/CT over MDCT in assessment of ovarian cancer patient The Egyptian Journal of Radiology and Nuclear Medicine FDG PET/CT MDCT Ovarian cancer |
| title | The predominant role of 18F-FDG PET/CT over MDCT in assessment of ovarian cancer patient |
| title_full | The predominant role of 18F-FDG PET/CT over MDCT in assessment of ovarian cancer patient |
| title_fullStr | The predominant role of 18F-FDG PET/CT over MDCT in assessment of ovarian cancer patient |
| title_full_unstemmed | The predominant role of 18F-FDG PET/CT over MDCT in assessment of ovarian cancer patient |
| title_short | The predominant role of 18F-FDG PET/CT over MDCT in assessment of ovarian cancer patient |
| title_sort | predominant role of 18f fdg pet ct over mdct in assessment of ovarian cancer patient |
| topic | FDG PET/CT MDCT Ovarian cancer |
| url | http://www.sciencedirect.com/science/article/pii/S0378603X15001771 |
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