The Effect of PCSK9 Inhibition on the Stabilization of Atherosclerotic Plaque Determined by Biochemical and Diagnostic Imaging Methods
Atherosclerosis is a multifactorial, progressive, chronic inflammatory disease. Ultrasound and magnetic resonance imaging are the most accurate predictors of atherosclerotic plaque instability (MRI). Cytokines such as osteopontin, osteoprotegerin, and metalloproteinase 9 could be used as the most re...
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MDPI AG
2023-08-01
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| author | Marcin Basiak Marcin Hachula Michal Kosowski Grzegorz Machnik Mateusz Maliglowka Maria Dziubinska-Basiak Robert Krysiak Boguslaw Okopien |
| author_facet | Marcin Basiak Marcin Hachula Michal Kosowski Grzegorz Machnik Mateusz Maliglowka Maria Dziubinska-Basiak Robert Krysiak Boguslaw Okopien |
| author_sort | Marcin Basiak |
| collection | DOAJ |
| description | Atherosclerosis is a multifactorial, progressive, chronic inflammatory disease. Ultrasound and magnetic resonance imaging are the most accurate predictors of atherosclerotic plaque instability (MRI). Cytokines such as osteopontin, osteoprotegerin, and metalloproteinase 9 could be used as the most recent markers to identify and track the efficacy of anti-atherosclerotic therapy. Patients with USG and MRI-verified unstable atherosclerotic plaque were included in the study. Biomarker concentrations were measured and compared before and after PCSK9 inhibitor therapy. Additionally, concentrations prior to treatment were correlated with MRI images of the carotid artery. After treatment with alirocumab, the concentrations of MMP-9 (<i>p</i> < 0.01) and OPN, OPG (<i>p</i> < 0.05) decreased significantly. Furthermore, the results of OPN, OPG, and MMP 9 varied significantly depending on the type of atherosclerotic plaque in the MRI assay. In stable atherosclerotic plaques, the concentrations of OPN and OPG were greater (<i>p</i> < 0.01), whereas the concentration of MMP9 correlated with the instability of the plaque (<i>p</i> < 0.05). We demonstrated, probably for the first time, that alirocumab therapy significantly decreased the serum concentration of atherosclerotic plaque markers. In addition, we demonstrated the relationship between the type of atherosclerotic plaque as determined by carotid MRI and the concentration of these markers. |
| first_indexed | 2024-03-11T00:20:29Z |
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| issn | 1420-3049 |
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| publishDate | 2023-08-01 |
| publisher | MDPI AG |
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| series | Molecules |
| spelling | doaj.art-5da2f9b847b74eba9a260e81f8dc4ed72023-11-18T23:20:43ZengMDPI AGMolecules1420-30492023-08-012815592810.3390/molecules28155928The Effect of PCSK9 Inhibition on the Stabilization of Atherosclerotic Plaque Determined by Biochemical and Diagnostic Imaging MethodsMarcin Basiak0Marcin Hachula1Michal Kosowski2Grzegorz Machnik3Mateusz Maliglowka4Maria Dziubinska-Basiak5Robert Krysiak6Boguslaw Okopien7Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Medyków 18, 40-752 Katowice, PolandDepartment of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Medyków 18, 40-752 Katowice, PolandDepartment of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Medyków 18, 40-752 Katowice, PolandDepartment of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Medyków 18, 40-752 Katowice, PolandDepartment of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Medyków 18, 40-752 Katowice, PolandSCANiX Medical Imaging, Ceglana 35, 40-514 Katowice, PolandDepartment of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Medyków 18, 40-752 Katowice, PolandDepartment of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Medyków 18, 40-752 Katowice, PolandAtherosclerosis is a multifactorial, progressive, chronic inflammatory disease. Ultrasound and magnetic resonance imaging are the most accurate predictors of atherosclerotic plaque instability (MRI). Cytokines such as osteopontin, osteoprotegerin, and metalloproteinase 9 could be used as the most recent markers to identify and track the efficacy of anti-atherosclerotic therapy. Patients with USG and MRI-verified unstable atherosclerotic plaque were included in the study. Biomarker concentrations were measured and compared before and after PCSK9 inhibitor therapy. Additionally, concentrations prior to treatment were correlated with MRI images of the carotid artery. After treatment with alirocumab, the concentrations of MMP-9 (<i>p</i> < 0.01) and OPN, OPG (<i>p</i> < 0.05) decreased significantly. Furthermore, the results of OPN, OPG, and MMP 9 varied significantly depending on the type of atherosclerotic plaque in the MRI assay. In stable atherosclerotic plaques, the concentrations of OPN and OPG were greater (<i>p</i> < 0.01), whereas the concentration of MMP9 correlated with the instability of the plaque (<i>p</i> < 0.05). We demonstrated, probably for the first time, that alirocumab therapy significantly decreased the serum concentration of atherosclerotic plaque markers. In addition, we demonstrated the relationship between the type of atherosclerotic plaque as determined by carotid MRI and the concentration of these markers.https://www.mdpi.com/1420-3049/28/15/5928PCSK-9 inhibitorsatherosclerotic plaquecarotid MRIosteopontinosteoprotegerinmatrix metalloproteinases |
| spellingShingle | Marcin Basiak Marcin Hachula Michal Kosowski Grzegorz Machnik Mateusz Maliglowka Maria Dziubinska-Basiak Robert Krysiak Boguslaw Okopien The Effect of PCSK9 Inhibition on the Stabilization of Atherosclerotic Plaque Determined by Biochemical and Diagnostic Imaging Methods Molecules PCSK-9 inhibitors atherosclerotic plaque carotid MRI osteopontin osteoprotegerin matrix metalloproteinases |
| title | The Effect of PCSK9 Inhibition on the Stabilization of Atherosclerotic Plaque Determined by Biochemical and Diagnostic Imaging Methods |
| title_full | The Effect of PCSK9 Inhibition on the Stabilization of Atherosclerotic Plaque Determined by Biochemical and Diagnostic Imaging Methods |
| title_fullStr | The Effect of PCSK9 Inhibition on the Stabilization of Atherosclerotic Plaque Determined by Biochemical and Diagnostic Imaging Methods |
| title_full_unstemmed | The Effect of PCSK9 Inhibition on the Stabilization of Atherosclerotic Plaque Determined by Biochemical and Diagnostic Imaging Methods |
| title_short | The Effect of PCSK9 Inhibition on the Stabilization of Atherosclerotic Plaque Determined by Biochemical and Diagnostic Imaging Methods |
| title_sort | effect of pcsk9 inhibition on the stabilization of atherosclerotic plaque determined by biochemical and diagnostic imaging methods |
| topic | PCSK-9 inhibitors atherosclerotic plaque carotid MRI osteopontin osteoprotegerin matrix metalloproteinases |
| url | https://www.mdpi.com/1420-3049/28/15/5928 |
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