Collagen-based biomaterials in organoid technology for reproductive medicine: composition, characteristics, and applications
Abstract Collagen-based biomaterials (CBB) are highly esteemed by researchers in materials science and biomedicine due to their extensive applications across various biomedical disciplines. In recent years, owing to advancements in developmental biology techniques, this superior biomaterial has seen...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2023-12-01
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| Series: | Collagen and Leather |
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| Online Access: | https://doi.org/10.1186/s42825-023-00142-6 |
| _version_ | 1797376768087162880 |
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| author | Bo Feng Hao Yang Manman Zhu Jinlin Li Hsun-Ming Chang Peter C. K. Leung Junling Guo Yaoyao Zhang |
| author_facet | Bo Feng Hao Yang Manman Zhu Jinlin Li Hsun-Ming Chang Peter C. K. Leung Junling Guo Yaoyao Zhang |
| author_sort | Bo Feng |
| collection | DOAJ |
| description | Abstract Collagen-based biomaterials (CBB) are highly esteemed by researchers in materials science and biomedicine due to their extensive applications across various biomedical disciplines. In recent years, owing to advancements in developmental biology techniques, this superior biomaterial has seen increasing utilization in 3D in vitro tissue culture. Three-dimensional cell cultures, often referred to as organoids, have emerged in response to technological advancements in biomaterials and the growing need in the field of medical research. They serve as important models for simulating normal physiological activities in vivo, addressing limitations in experimental material sources, and resolving ethical issues. In this review, we discuss the material characteristics of CBBs commonly used for organoid culture, integrating aspects such as Matrigel and decellularized ECM as culture matrices. We also analyzed the development prospects and directions of various materials in the context of biology, clinical medicine, and particularly reproductive medicine. Currently, despite the FDA approval and clinical research incorporating numerous CBBs, existing challenges in multiple studies indicate a significant unmet need in the development of key tissue models for both medical research and clinical applications. In summary, CBBs are swiftly broadening their applicability in the realms of organoid nature and medical research, serving as a versatile and high-performing material for 3D in vitro tissue culture. Graphical abstract |
| first_indexed | 2024-03-08T19:43:22Z |
| format | Article |
| id | doaj.art-5da37ccc36ec4429b468cd597045961a |
| institution | Directory Open Access Journal |
| issn | 2097-1419 2731-6998 |
| language | English |
| last_indexed | 2024-03-08T19:43:22Z |
| publishDate | 2023-12-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Collagen and Leather |
| spelling | doaj.art-5da37ccc36ec4429b468cd597045961a2023-12-24T12:29:14ZengSpringerOpenCollagen and Leather2097-14192731-69982023-12-015112610.1186/s42825-023-00142-6Collagen-based biomaterials in organoid technology for reproductive medicine: composition, characteristics, and applicationsBo Feng0Hao Yang1Manman Zhu2Jinlin Li3Hsun-Ming Chang4Peter C. K. Leung5Junling Guo6Yaoyao Zhang7Department of Obstetrics and Gynecology, Key Laboratory of Birth Defects and Related of Women and Children of Ministry of Education, West China Second University Hospital, Sichuan University, Frontier Medical Center, Tianfu Jincheng LaboratoryDepartment of Obstetrics and Gynecology, Key Laboratory of Birth Defects and Related of Women and Children of Ministry of Education, West China Second University Hospital, Sichuan University, Frontier Medical Center, Tianfu Jincheng LaboratoryDepartment of Obstetrics and Gynecology, Key Laboratory of Birth Defects and Related of Women and Children of Ministry of Education, West China Second University Hospital, Sichuan University, Frontier Medical Center, Tianfu Jincheng LaboratorySichuan University Department of Polymer Science: Sichuan University College of Polymer Science and EngineeringDepartment of Obstetrics and Gynecology, Reproductive Medicine Center, China Medical University HospitalDepartment of Obstetrics and Gynecology, BC Children’s Hospital Research Institute, University of British ColumbiaBMI Center for Biomass Materials and Nanointerfaces, College of Biomass Science and Engineering, Sichuan UniversityDepartment of Obstetrics and Gynecology, Key Laboratory of Birth Defects and Related of Women and Children of Ministry of Education, West China Second University Hospital, Sichuan University, Frontier Medical Center, Tianfu Jincheng LaboratoryAbstract Collagen-based biomaterials (CBB) are highly esteemed by researchers in materials science and biomedicine due to their extensive applications across various biomedical disciplines. In recent years, owing to advancements in developmental biology techniques, this superior biomaterial has seen increasing utilization in 3D in vitro tissue culture. Three-dimensional cell cultures, often referred to as organoids, have emerged in response to technological advancements in biomaterials and the growing need in the field of medical research. They serve as important models for simulating normal physiological activities in vivo, addressing limitations in experimental material sources, and resolving ethical issues. In this review, we discuss the material characteristics of CBBs commonly used for organoid culture, integrating aspects such as Matrigel and decellularized ECM as culture matrices. We also analyzed the development prospects and directions of various materials in the context of biology, clinical medicine, and particularly reproductive medicine. Currently, despite the FDA approval and clinical research incorporating numerous CBBs, existing challenges in multiple studies indicate a significant unmet need in the development of key tissue models for both medical research and clinical applications. In summary, CBBs are swiftly broadening their applicability in the realms of organoid nature and medical research, serving as a versatile and high-performing material for 3D in vitro tissue culture. Graphical abstracthttps://doi.org/10.1186/s42825-023-00142-6CollagenOrganoidsBiomaterialsApplicationsComponent and characteristics |
| spellingShingle | Bo Feng Hao Yang Manman Zhu Jinlin Li Hsun-Ming Chang Peter C. K. Leung Junling Guo Yaoyao Zhang Collagen-based biomaterials in organoid technology for reproductive medicine: composition, characteristics, and applications Collagen and Leather Collagen Organoids Biomaterials Applications Component and characteristics |
| title | Collagen-based biomaterials in organoid technology for reproductive medicine: composition, characteristics, and applications |
| title_full | Collagen-based biomaterials in organoid technology for reproductive medicine: composition, characteristics, and applications |
| title_fullStr | Collagen-based biomaterials in organoid technology for reproductive medicine: composition, characteristics, and applications |
| title_full_unstemmed | Collagen-based biomaterials in organoid technology for reproductive medicine: composition, characteristics, and applications |
| title_short | Collagen-based biomaterials in organoid technology for reproductive medicine: composition, characteristics, and applications |
| title_sort | collagen based biomaterials in organoid technology for reproductive medicine composition characteristics and applications |
| topic | Collagen Organoids Biomaterials Applications Component and characteristics |
| url | https://doi.org/10.1186/s42825-023-00142-6 |
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