Effects of co-administered dexamethasone and diclofenac potassium on pain, swelling and trismus following third molar surgery
<p>Abstract</p> <p>Background</p> <p>The apparent interactions between the mechanisms of action of non-steroidal anti-inflammatory drugs (NSAIDS) and steroids suggest that co-therapy may provide beneficial inflammatory and pain relief in the absence of side effects. The...
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| Format: | Article |
| Language: | English |
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BMC
2005-11-01
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| Series: | Head & Face Medicine |
| Online Access: | http://www.head-face-med.com/content/1/1/11 |
| _version_ | 1818261745858248704 |
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| author | Arotiba Godwin Ladeinde Akinola Adeyemo Wasiu Akinwande Jelili Bamgbose Babatunde Ogunlewe Mobolanle |
| author_facet | Arotiba Godwin Ladeinde Akinola Adeyemo Wasiu Akinwande Jelili Bamgbose Babatunde Ogunlewe Mobolanle |
| author_sort | Arotiba Godwin |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>The apparent interactions between the mechanisms of action of non-steroidal anti-inflammatory drugs (NSAIDS) and steroids suggest that co-therapy may provide beneficial inflammatory and pain relief in the absence of side effects. The aim of the study was to compare the effect of co-administered dexamethasone and diclofenac potassium (diclofenac K) with diclofenac K alone on the postoperative pain, swelling and trismus after surgical removal of third molars.</p> <p>Patients and Methods</p> <p>A prospective randomized double-blind study was conducted at the Department of Oral and Maxillofacial Surgery, Lagos University Teaching Hospital, Nigeria. A total of 100 patients were randomly allocated to two treatment groups of dexamethasone (prophylactic 8 mg and postoperative 4 mg IV) and diclofenac K (50 mg Oral before and after surgery), and diclofenac K alone (as with first group). The overall analgesic efficacy of the drug combinations was assessed postoperatively by determination of pain intensity using a category rating scale. Facial swelling was measured using a tape measure placed from tragus to gonion to tragus, while interincisal mouth-opening of patients was measured using a vernier calibrated caliper pre-operatively and post-operatively.</p> <p>Results</p> <p>Co-administration of dexamethasone and diclofenac K was significantly superior to diclofenac alone for the relief of pain (P < 0.05), and facial swelling up to post-operative 48 hour (P < 0.05). However, there was no significant difference for trismus relief between the two medication protocols (P > 0.05).</p> <p>Conclusion</p> <p>This study illustrates enhanced effects of co-administered dexamethasone and diclofenac K on short-term post-operative pain and swelling, compared to diclofenac potassium alone in third molar surgery.</p> |
| first_indexed | 2024-12-12T18:52:07Z |
| format | Article |
| id | doaj.art-5da5084b235545d893b2110f27b1ab3c |
| institution | Directory Open Access Journal |
| issn | 1746-160X |
| language | English |
| last_indexed | 2024-12-12T18:52:07Z |
| publishDate | 2005-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Head & Face Medicine |
| spelling | doaj.art-5da5084b235545d893b2110f27b1ab3c2022-12-22T00:15:21ZengBMCHead & Face Medicine1746-160X2005-11-01111110.1186/1746-160X-1-11Effects of co-administered dexamethasone and diclofenac potassium on pain, swelling and trismus following third molar surgeryArotiba GodwinLadeinde AkinolaAdeyemo WasiuAkinwande JeliliBamgbose BabatundeOgunlewe Mobolanle<p>Abstract</p> <p>Background</p> <p>The apparent interactions between the mechanisms of action of non-steroidal anti-inflammatory drugs (NSAIDS) and steroids suggest that co-therapy may provide beneficial inflammatory and pain relief in the absence of side effects. The aim of the study was to compare the effect of co-administered dexamethasone and diclofenac potassium (diclofenac K) with diclofenac K alone on the postoperative pain, swelling and trismus after surgical removal of third molars.</p> <p>Patients and Methods</p> <p>A prospective randomized double-blind study was conducted at the Department of Oral and Maxillofacial Surgery, Lagos University Teaching Hospital, Nigeria. A total of 100 patients were randomly allocated to two treatment groups of dexamethasone (prophylactic 8 mg and postoperative 4 mg IV) and diclofenac K (50 mg Oral before and after surgery), and diclofenac K alone (as with first group). The overall analgesic efficacy of the drug combinations was assessed postoperatively by determination of pain intensity using a category rating scale. Facial swelling was measured using a tape measure placed from tragus to gonion to tragus, while interincisal mouth-opening of patients was measured using a vernier calibrated caliper pre-operatively and post-operatively.</p> <p>Results</p> <p>Co-administration of dexamethasone and diclofenac K was significantly superior to diclofenac alone for the relief of pain (P < 0.05), and facial swelling up to post-operative 48 hour (P < 0.05). However, there was no significant difference for trismus relief between the two medication protocols (P > 0.05).</p> <p>Conclusion</p> <p>This study illustrates enhanced effects of co-administered dexamethasone and diclofenac K on short-term post-operative pain and swelling, compared to diclofenac potassium alone in third molar surgery.</p>http://www.head-face-med.com/content/1/1/11 |
| spellingShingle | Arotiba Godwin Ladeinde Akinola Adeyemo Wasiu Akinwande Jelili Bamgbose Babatunde Ogunlewe Mobolanle Effects of co-administered dexamethasone and diclofenac potassium on pain, swelling and trismus following third molar surgery Head & Face Medicine |
| title | Effects of co-administered dexamethasone and diclofenac potassium on pain, swelling and trismus following third molar surgery |
| title_full | Effects of co-administered dexamethasone and diclofenac potassium on pain, swelling and trismus following third molar surgery |
| title_fullStr | Effects of co-administered dexamethasone and diclofenac potassium on pain, swelling and trismus following third molar surgery |
| title_full_unstemmed | Effects of co-administered dexamethasone and diclofenac potassium on pain, swelling and trismus following third molar surgery |
| title_short | Effects of co-administered dexamethasone and diclofenac potassium on pain, swelling and trismus following third molar surgery |
| title_sort | effects of co administered dexamethasone and diclofenac potassium on pain swelling and trismus following third molar surgery |
| url | http://www.head-face-med.com/content/1/1/11 |
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