Promotion of microRNA-146a by histone deacetylase 4 silencing contributes to radiosensitization of esophageal carcinoma

Promotion of microRNA-146a by histone deacetylase 4 silencing contributes to radiosensitization of esophageal carcinoma

Abstract Background Histone deacetylases (HDACs) have been identified to be implicated in the carcinogenesis and cancer progression. The present study was performed to probe into the effect of HDAC4 on radioresistance of esophageal carcinoma (EC). Methods The expression of HDAC4 in responders and no...

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Bibliographic Details
Main Authors: Zhonghua Lu, Yifei Yun, Yutong Zhang, Yao Ou, Meihua Wang
Format: Article
Language:English
Published: BMC 2022-02-01
Series:Journal of Translational Medicine
Subjects:
Esophageal carcinoma
Histone deacetylase 4
miR-146a
IRAK1
Radioresistance
In vitro and in vivo studies
Online Access:https://doi.org/10.1186/s12967-021-03171-z

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