A Benzoic Acid Derivative and Flavokawains from Piper species as Schistosomiasis Vector Controls
The search of alternative compounds to control tropical diseases such as schistosomiasis has pointed to secondary metabolites derived from natural sources. Piper species are candidates in strategies to control the transmission of schistosomiasis due to their production of molluscicidal compounds. A...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2014-04-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1420-3049/19/4/5205 |
| _version_ | 1828451609058738176 |
|---|---|
| author | Ludmila N. Rapado Giovana C. Freitas Adriano Polpo Maritza Rojas-Cardozo Javier V. Rincón Marcus T. Scotti Massuo J. Kato Eliana Nakano Lydia F. Yamaguchi |
| author_facet | Ludmila N. Rapado Giovana C. Freitas Adriano Polpo Maritza Rojas-Cardozo Javier V. Rincón Marcus T. Scotti Massuo J. Kato Eliana Nakano Lydia F. Yamaguchi |
| author_sort | Ludmila N. Rapado |
| collection | DOAJ |
| description | The search of alternative compounds to control tropical diseases such as schistosomiasis has pointed to secondary metabolites derived from natural sources. Piper species are candidates in strategies to control the transmission of schistosomiasis due to their production of molluscicidal compounds. A new benzoic acid derivative and three flavokawains from Piper diospyrifolium, P. cumanense and P. gaudichaudianum displayed significant activities against Biomphalaria glabrata snails. Additionally, “in silico” studies were performed using docking assays and Molecular Interaction Fields to evaluate the physical-chemical differences among the compounds in order to characterize the observed activities of the test compounds against Biomphalaria glabrata snails. |
| first_indexed | 2024-12-10T23:39:08Z |
| format | Article |
| id | doaj.art-5daa0e119f924bd8b465e2bbf42dcfe1 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-10T23:39:08Z |
| publishDate | 2014-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-5daa0e119f924bd8b465e2bbf42dcfe12022-12-22T01:29:05ZengMDPI AGMolecules1420-30492014-04-011945205521810.3390/molecules19045205molecules19045205A Benzoic Acid Derivative and Flavokawains from Piper species as Schistosomiasis Vector ControlsLudmila N. Rapado0Giovana C. Freitas1Adriano Polpo2Maritza Rojas-Cardozo3Javier V. Rincón4Marcus T. Scotti5Massuo J. Kato6Eliana Nakano7Lydia F. Yamaguchi8Laboratório de Parasitologia, Instituto Butantan, Av. Vital Brasil, 1500, São Paulo, SP, CEP 05503-900, BrazilResearch Support Center in Diversity of Natural Products, Instituto de Química, Universidade de São Paulo, Av. Prof. Lineu Prestes, 748, sala 1124, São Paulo, SP, CEP 05508-000, BrazilDepartamento de Estatística, Centro de Ciências Exatas e de Tecnologia, Universidade Federal de São Carlos, Via Washington Luís, km 235, Sao Carlos, SP, Caixa-postal 676, CEP 13565-905, BrazilDepartment of Pharmacy, Faculty of Sciences, Universidad Nacional de Colombia, Kr 30 45-03, Bogotá, ColombiaDepartment of Pharmacy, Faculty of Sciences, Universidad Nacional de Colombia, Kr 30 45-03, Bogotá, ColombiaCentro de Ciências Aplicadas e Educação, Universidade Federal da Paraíba, Campus IV, Rua da Mangueira, s/n, Rio Tinto, PB, CEP 5829-7000, BrazilResearch Support Center in Diversity of Natural Products, Instituto de Química, Universidade de São Paulo, Av. Prof. Lineu Prestes, 748, sala 1124, São Paulo, SP, CEP 05508-000, BrazilLaboratório de Parasitologia, Instituto Butantan, Av. Vital Brasil, 1500, São Paulo, SP, CEP 05503-900, BrazilResearch Support Center in Diversity of Natural Products, Instituto de Química, Universidade de São Paulo, Av. Prof. Lineu Prestes, 748, sala 1124, São Paulo, SP, CEP 05508-000, BrazilThe search of alternative compounds to control tropical diseases such as schistosomiasis has pointed to secondary metabolites derived from natural sources. Piper species are candidates in strategies to control the transmission of schistosomiasis due to their production of molluscicidal compounds. A new benzoic acid derivative and three flavokawains from Piper diospyrifolium, P. cumanense and P. gaudichaudianum displayed significant activities against Biomphalaria glabrata snails. Additionally, “in silico” studies were performed using docking assays and Molecular Interaction Fields to evaluate the physical-chemical differences among the compounds in order to characterize the observed activities of the test compounds against Biomphalaria glabrata snails.http://www.mdpi.com/1420-3049/19/4/5205schistosomiasismolluscicidebenzoic acidflavokawainPiper |
| spellingShingle | Ludmila N. Rapado Giovana C. Freitas Adriano Polpo Maritza Rojas-Cardozo Javier V. Rincón Marcus T. Scotti Massuo J. Kato Eliana Nakano Lydia F. Yamaguchi A Benzoic Acid Derivative and Flavokawains from Piper species as Schistosomiasis Vector Controls Molecules schistosomiasis molluscicide benzoic acid flavokawain Piper |
| title | A Benzoic Acid Derivative and Flavokawains from Piper species as Schistosomiasis Vector Controls |
| title_full | A Benzoic Acid Derivative and Flavokawains from Piper species as Schistosomiasis Vector Controls |
| title_fullStr | A Benzoic Acid Derivative and Flavokawains from Piper species as Schistosomiasis Vector Controls |
| title_full_unstemmed | A Benzoic Acid Derivative and Flavokawains from Piper species as Schistosomiasis Vector Controls |
| title_short | A Benzoic Acid Derivative and Flavokawains from Piper species as Schistosomiasis Vector Controls |
| title_sort | benzoic acid derivative and flavokawains from piper species as schistosomiasis vector controls |
| topic | schistosomiasis molluscicide benzoic acid flavokawain Piper |
| url | http://www.mdpi.com/1420-3049/19/4/5205 |
| work_keys_str_mv | AT ludmilanrapado abenzoicacidderivativeandflavokawainsfrompiperspeciesasschistosomiasisvectorcontrols AT giovanacfreitas abenzoicacidderivativeandflavokawainsfrompiperspeciesasschistosomiasisvectorcontrols AT adrianopolpo abenzoicacidderivativeandflavokawainsfrompiperspeciesasschistosomiasisvectorcontrols AT maritzarojascardozo abenzoicacidderivativeandflavokawainsfrompiperspeciesasschistosomiasisvectorcontrols AT javiervrincon abenzoicacidderivativeandflavokawainsfrompiperspeciesasschistosomiasisvectorcontrols AT marcustscotti abenzoicacidderivativeandflavokawainsfrompiperspeciesasschistosomiasisvectorcontrols AT massuojkato abenzoicacidderivativeandflavokawainsfrompiperspeciesasschistosomiasisvectorcontrols AT eliananakano abenzoicacidderivativeandflavokawainsfrompiperspeciesasschistosomiasisvectorcontrols AT lydiafyamaguchi abenzoicacidderivativeandflavokawainsfrompiperspeciesasschistosomiasisvectorcontrols AT ludmilanrapado benzoicacidderivativeandflavokawainsfrompiperspeciesasschistosomiasisvectorcontrols AT giovanacfreitas benzoicacidderivativeandflavokawainsfrompiperspeciesasschistosomiasisvectorcontrols AT adrianopolpo benzoicacidderivativeandflavokawainsfrompiperspeciesasschistosomiasisvectorcontrols AT maritzarojascardozo benzoicacidderivativeandflavokawainsfrompiperspeciesasschistosomiasisvectorcontrols AT javiervrincon benzoicacidderivativeandflavokawainsfrompiperspeciesasschistosomiasisvectorcontrols AT marcustscotti benzoicacidderivativeandflavokawainsfrompiperspeciesasschistosomiasisvectorcontrols AT massuojkato benzoicacidderivativeandflavokawainsfrompiperspeciesasschistosomiasisvectorcontrols AT eliananakano benzoicacidderivativeandflavokawainsfrompiperspeciesasschistosomiasisvectorcontrols AT lydiafyamaguchi benzoicacidderivativeandflavokawainsfrompiperspeciesasschistosomiasisvectorcontrols |