The importance of pharmacogenetic research for optimization of antihypertensive treatment

As time goes by, significant individuality of antihypertensive drugs effectiveness may be clarified by pharmacogenetic research methods. Pronounced variability of pharmacological response may be caused by mononucleotide substitutions in genes, coding biotransformation enzymes. The present work is de...

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Main Authors: O V Shevchenko, E N Bychkov, O M Posnenkova, P Ya Dovgalevsky, S I Bogoslovskaya, A A Svistunov
Format: Article
Language:English
Published: Peoples’ Friendship University of Russia (RUDN University) 2012-09-01
Series:RUDN Journal of Medicine
Subjects:
Online Access:http://journals.rudn.ru/medicine/article/view/3622
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author O V Shevchenko
E N Bychkov
O M Posnenkova
P Ya Dovgalevsky
S I Bogoslovskaya
A A Svistunov
author_facet O V Shevchenko
E N Bychkov
O M Posnenkova
P Ya Dovgalevsky
S I Bogoslovskaya
A A Svistunov
author_sort O V Shevchenko
collection DOAJ
description As time goes by, significant individuality of antihypertensive drugs effectiveness may be clarified by pharmacogenetic research methods. Pronounced variability of pharmacological response may be caused by mononucleotide substitutions in genes, coding biotransformation enzymes. The present work is dedicated to investigation of allelic variants of functionally defective genes CYP2D6 and CYP2C9 in patients with arterial hypertension. Possible relation of distinct associations of polymorphous gene variants with difference in individual sensitivity to beta-blockers and angiotensin receptor blockers was shown.
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spelling doaj.art-5dad840aa30b42949e8cf32ca56ce3322022-12-21T23:58:32ZengPeoples’ Friendship University of Russia (RUDN University)RUDN Journal of Medicine2313-02452313-02612012-09-0103951003622The importance of pharmacogenetic research for optimization of antihypertensive treatmentO V Shevchenko0E N Bychkov1O M Posnenkova2P Ya Dovgalevsky3S I Bogoslovskaya4A A Svistunov5Саратовский государственный медицинский университетим. В.И. Разумовского Минздравсоцразвития РосздраваСаратовский государственный медицинский университетим. В.И. Разумовского Минздравсоцразвития РосздраваСаратовский НИИ кардиологии Минздравсоцразвития РоссииСаратовский НИИ кардиологии Минздравсоцразвития РоссииСаратовский государственный медицинский университетим. В.И. Разумовского Минздравсоцразвития РосздраваНаучно-исследовательский институт фармацииПервый московский государственный медицинский университет им. И.М. СеченоваAs time goes by, significant individuality of antihypertensive drugs effectiveness may be clarified by pharmacogenetic research methods. Pronounced variability of pharmacological response may be caused by mononucleotide substitutions in genes, coding biotransformation enzymes. The present work is dedicated to investigation of allelic variants of functionally defective genes CYP2D6 and CYP2C9 in patients with arterial hypertension. Possible relation of distinct associations of polymorphous gene variants with difference in individual sensitivity to beta-blockers and angiotensin receptor blockers was shown.http://journals.rudn.ru/medicine/article/view/3622антигипертензивная терапияцитохром Р450фармакогенетикабиочипы
spellingShingle O V Shevchenko
E N Bychkov
O M Posnenkova
P Ya Dovgalevsky
S I Bogoslovskaya
A A Svistunov
The importance of pharmacogenetic research for optimization of antihypertensive treatment
RUDN Journal of Medicine
антигипертензивная терапия
цитохром Р450
фармакогенетика
биочипы
title The importance of pharmacogenetic research for optimization of antihypertensive treatment
title_full The importance of pharmacogenetic research for optimization of antihypertensive treatment
title_fullStr The importance of pharmacogenetic research for optimization of antihypertensive treatment
title_full_unstemmed The importance of pharmacogenetic research for optimization of antihypertensive treatment
title_short The importance of pharmacogenetic research for optimization of antihypertensive treatment
title_sort importance of pharmacogenetic research for optimization of antihypertensive treatment
topic антигипертензивная терапия
цитохром Р450
фармакогенетика
биочипы
url http://journals.rudn.ru/medicine/article/view/3622
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