The importance of pharmacogenetic research for optimization of antihypertensive treatment
As time goes by, significant individuality of antihypertensive drugs effectiveness may be clarified by pharmacogenetic research methods. Pronounced variability of pharmacological response may be caused by mononucleotide substitutions in genes, coding biotransformation enzymes. The present work is de...
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Format: | Article |
Language: | English |
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Peoples’ Friendship University of Russia (RUDN University)
2012-09-01
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Series: | RUDN Journal of Medicine |
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Online Access: | http://journals.rudn.ru/medicine/article/view/3622 |
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author | O V Shevchenko E N Bychkov O M Posnenkova P Ya Dovgalevsky S I Bogoslovskaya A A Svistunov |
author_facet | O V Shevchenko E N Bychkov O M Posnenkova P Ya Dovgalevsky S I Bogoslovskaya A A Svistunov |
author_sort | O V Shevchenko |
collection | DOAJ |
description | As time goes by, significant individuality of antihypertensive drugs effectiveness may be clarified by pharmacogenetic research methods. Pronounced variability of pharmacological response may be caused by mononucleotide substitutions in genes, coding biotransformation enzymes. The present work is dedicated to investigation of allelic variants of functionally defective genes CYP2D6 and CYP2C9 in patients with arterial hypertension. Possible relation of distinct associations of polymorphous gene variants with difference in individual sensitivity to beta-blockers and angiotensin receptor blockers was shown. |
first_indexed | 2024-12-13T05:10:42Z |
format | Article |
id | doaj.art-5dad840aa30b42949e8cf32ca56ce332 |
institution | Directory Open Access Journal |
issn | 2313-0245 2313-0261 |
language | English |
last_indexed | 2024-12-13T05:10:42Z |
publishDate | 2012-09-01 |
publisher | Peoples’ Friendship University of Russia (RUDN University) |
record_format | Article |
series | RUDN Journal of Medicine |
spelling | doaj.art-5dad840aa30b42949e8cf32ca56ce3322022-12-21T23:58:32ZengPeoples’ Friendship University of Russia (RUDN University)RUDN Journal of Medicine2313-02452313-02612012-09-0103951003622The importance of pharmacogenetic research for optimization of antihypertensive treatmentO V Shevchenko0E N Bychkov1O M Posnenkova2P Ya Dovgalevsky3S I Bogoslovskaya4A A Svistunov5Саратовский государственный медицинский университетим. В.И. Разумовского Минздравсоцразвития РосздраваСаратовский государственный медицинский университетим. В.И. Разумовского Минздравсоцразвития РосздраваСаратовский НИИ кардиологии Минздравсоцразвития РоссииСаратовский НИИ кардиологии Минздравсоцразвития РоссииСаратовский государственный медицинский университетим. В.И. Разумовского Минздравсоцразвития РосздраваНаучно-исследовательский институт фармацииПервый московский государственный медицинский университет им. И.М. СеченоваAs time goes by, significant individuality of antihypertensive drugs effectiveness may be clarified by pharmacogenetic research methods. Pronounced variability of pharmacological response may be caused by mononucleotide substitutions in genes, coding biotransformation enzymes. The present work is dedicated to investigation of allelic variants of functionally defective genes CYP2D6 and CYP2C9 in patients with arterial hypertension. Possible relation of distinct associations of polymorphous gene variants with difference in individual sensitivity to beta-blockers and angiotensin receptor blockers was shown.http://journals.rudn.ru/medicine/article/view/3622антигипертензивная терапияцитохром Р450фармакогенетикабиочипы |
spellingShingle | O V Shevchenko E N Bychkov O M Posnenkova P Ya Dovgalevsky S I Bogoslovskaya A A Svistunov The importance of pharmacogenetic research for optimization of antihypertensive treatment RUDN Journal of Medicine антигипертензивная терапия цитохром Р450 фармакогенетика биочипы |
title | The importance of pharmacogenetic research for optimization of antihypertensive treatment |
title_full | The importance of pharmacogenetic research for optimization of antihypertensive treatment |
title_fullStr | The importance of pharmacogenetic research for optimization of antihypertensive treatment |
title_full_unstemmed | The importance of pharmacogenetic research for optimization of antihypertensive treatment |
title_short | The importance of pharmacogenetic research for optimization of antihypertensive treatment |
title_sort | importance of pharmacogenetic research for optimization of antihypertensive treatment |
topic | антигипертензивная терапия цитохром Р450 фармакогенетика биочипы |
url | http://journals.rudn.ru/medicine/article/view/3622 |
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