Deep cerebral venous abnormalities in premature babies with GMH-IVH: a single-centre retrospective study
Purpose Germinal matrix haemorrhage/intraventricular haemorrhage (GMH-IVH) is a multifactorial injury with both anatomic and haemodynamic involvement. Normal variants in preterm deep cerebral venous anatomy associated with GMH-IVH have been previously described using MRI susceptibility weighted imag...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2023-12-01
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| Series: | BMJ Paediatrics Open |
| Online Access: | https://bmjpaedsopen.bmj.com/content/7/1/e001853.full |
| _version_ | 1797368452260823040 |
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| author | Livia Sura Mehmet Albayram Michael David Weiss Vikash Sinha Thomas Kent Elvan Ceyhan Ensar Yekeler |
| author_facet | Livia Sura Mehmet Albayram Michael David Weiss Vikash Sinha Thomas Kent Elvan Ceyhan Ensar Yekeler |
| author_sort | Livia Sura |
| collection | DOAJ |
| description | Purpose Germinal matrix haemorrhage/intraventricular haemorrhage (GMH-IVH) is a multifactorial injury with both anatomic and haemodynamic involvement. Normal variants in preterm deep cerebral venous anatomy associated with GMH-IVH have been previously described using MRI susceptibility weighted imaging (SWI). The aims of this study were to use SWI to compare the deep venous systems of a cohort of preterm neonates with various grades of GMH-IVH to a group of age-matched controls without GMH-IVH and to present novel retrospective SWI imaging findings.Methods A neuroradiologist retrospectively evaluated 3T MRI SWI and phase imaging of 56 preterm neonates with GMH-IVH (14 of each grade) and 27 controls without GMH-IVH, scoring the venous irregularities according to three variables: decreased venous patency, increased lumen susceptibility and the presence of collaterals. Eight different venous locations, including indicated bilateral components, were evaluated: straight sinus, vein of galen, internal cerebral, direct lateral, thalamostriate, atrial and the anterior septal veins. Variables were analysed for statistical significance. Inter-rater reliability was determined via subset evaluation by a second paediatric radiologist.Results Deep venous abnormalities were significantly more common in patients with GMH-IVH, with Wilcoxon Rank Sum Test demonstrating significant increase with GMH-IVH for total decreased venous patency (W=0, p<0.0001), increased lumen susceptibility and collateral formation. Venous abnormalities were also positively correlated with an increase in GMH-IVH grade from I to IV (patency, ρ=0.782, p<0.01) (increased lumen susceptibility, ρ=0.739, p<0.01) (collaterals, ρ=0.649, p<0.01), not just GMH-IVH alone.Conclusion Deep venous abnormalities are significantly correlated with GMH-IVH alone and an increase in GMH-IVH grade. Further study is needed to determine cause and effect. |
| first_indexed | 2024-03-08T17:32:40Z |
| format | Article |
| id | doaj.art-5dae3b92b3ce43b7956a375e71013785 |
| institution | Directory Open Access Journal |
| issn | 2399-9772 |
| language | English |
| last_indexed | 2024-03-08T17:32:40Z |
| publishDate | 2023-12-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Paediatrics Open |
| spelling | doaj.art-5dae3b92b3ce43b7956a375e710137852024-01-02T14:35:07ZengBMJ Publishing GroupBMJ Paediatrics Open2399-97722023-12-017110.1136/bmjpo-2023-001853Deep cerebral venous abnormalities in premature babies with GMH-IVH: a single-centre retrospective studyLivia Sura0Mehmet Albayram1Michael David Weiss2Vikash Sinha3Thomas Kent4Elvan Ceyhan5Ensar Yekeler6Department of Pediatrics, University of Florida College of Medicine, Gainesville, Florida, USADepartment of Radiology, University of Florida College of Medicine, Gainesville, Florida, USADepartment of Pediatrics, University of Florida College of Medicine, Gainesville, Florida, USADepartment of Radiology, University of Florida College of Medicine, Gainesville, Florida, USAUniversity of Florida College of Medicine, Gainesville, Florida, USADepartment of Mathematics and Statistics, Auburn University College of Sciences and Mathematics, Auburn, Alabama, USADepartment of Radiology, University of Florida College of Medicine, Gainesville, Florida, USAPurpose Germinal matrix haemorrhage/intraventricular haemorrhage (GMH-IVH) is a multifactorial injury with both anatomic and haemodynamic involvement. Normal variants in preterm deep cerebral venous anatomy associated with GMH-IVH have been previously described using MRI susceptibility weighted imaging (SWI). The aims of this study were to use SWI to compare the deep venous systems of a cohort of preterm neonates with various grades of GMH-IVH to a group of age-matched controls without GMH-IVH and to present novel retrospective SWI imaging findings.Methods A neuroradiologist retrospectively evaluated 3T MRI SWI and phase imaging of 56 preterm neonates with GMH-IVH (14 of each grade) and 27 controls without GMH-IVH, scoring the venous irregularities according to three variables: decreased venous patency, increased lumen susceptibility and the presence of collaterals. Eight different venous locations, including indicated bilateral components, were evaluated: straight sinus, vein of galen, internal cerebral, direct lateral, thalamostriate, atrial and the anterior septal veins. Variables were analysed for statistical significance. Inter-rater reliability was determined via subset evaluation by a second paediatric radiologist.Results Deep venous abnormalities were significantly more common in patients with GMH-IVH, with Wilcoxon Rank Sum Test demonstrating significant increase with GMH-IVH for total decreased venous patency (W=0, p<0.0001), increased lumen susceptibility and collateral formation. Venous abnormalities were also positively correlated with an increase in GMH-IVH grade from I to IV (patency, ρ=0.782, p<0.01) (increased lumen susceptibility, ρ=0.739, p<0.01) (collaterals, ρ=0.649, p<0.01), not just GMH-IVH alone.Conclusion Deep venous abnormalities are significantly correlated with GMH-IVH alone and an increase in GMH-IVH grade. Further study is needed to determine cause and effect.https://bmjpaedsopen.bmj.com/content/7/1/e001853.full |
| spellingShingle | Livia Sura Mehmet Albayram Michael David Weiss Vikash Sinha Thomas Kent Elvan Ceyhan Ensar Yekeler Deep cerebral venous abnormalities in premature babies with GMH-IVH: a single-centre retrospective study BMJ Paediatrics Open |
| title | Deep cerebral venous abnormalities in premature babies with GMH-IVH: a single-centre retrospective study |
| title_full | Deep cerebral venous abnormalities in premature babies with GMH-IVH: a single-centre retrospective study |
| title_fullStr | Deep cerebral venous abnormalities in premature babies with GMH-IVH: a single-centre retrospective study |
| title_full_unstemmed | Deep cerebral venous abnormalities in premature babies with GMH-IVH: a single-centre retrospective study |
| title_short | Deep cerebral venous abnormalities in premature babies with GMH-IVH: a single-centre retrospective study |
| title_sort | deep cerebral venous abnormalities in premature babies with gmh ivh a single centre retrospective study |
| url | https://bmjpaedsopen.bmj.com/content/7/1/e001853.full |
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