A PKB-SPEG signaling nexus links insulin resistance with diabetic cardiomyopathy by regulating calcium homeostasis
Molecular mechanisms linking myocardial insulin resistance to diabetic cardiomyopathy are incompletely understood. Here the authors show that myocardial insulin resistance impairs a PKB-SPEG-SERCA2a signaling axis, which contributes to the development of diabetic cardiomyopathy.
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-05-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-16116-9 |
| _version_ | 1831774096411590656 |
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| author | Chao Quan Qian Du Min Li Ruizhen Wang Qian Ouyang Shu Su Sangsang Zhu Qiaoli Chen Yang Sheng Liang Chen Hong Wang David G. Campbell Carol MacKintosh Zhongzhou Yang Kunfu Ouyang Hong Yu Wang Shuai Chen |
| author_facet | Chao Quan Qian Du Min Li Ruizhen Wang Qian Ouyang Shu Su Sangsang Zhu Qiaoli Chen Yang Sheng Liang Chen Hong Wang David G. Campbell Carol MacKintosh Zhongzhou Yang Kunfu Ouyang Hong Yu Wang Shuai Chen |
| author_sort | Chao Quan |
| collection | DOAJ |
| description | Molecular mechanisms linking myocardial insulin resistance to diabetic cardiomyopathy are incompletely understood. Here the authors show that myocardial insulin resistance impairs a PKB-SPEG-SERCA2a signaling axis, which contributes to the development of diabetic cardiomyopathy. |
| first_indexed | 2024-12-22T08:48:13Z |
| format | Article |
| id | doaj.art-5daf127d28454b4bae80efceddb9c9af |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-22T08:48:13Z |
| publishDate | 2020-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-5daf127d28454b4bae80efceddb9c9af2022-12-21T18:32:02ZengNature PortfolioNature Communications2041-17232020-05-0111111410.1038/s41467-020-16116-9A PKB-SPEG signaling nexus links insulin resistance with diabetic cardiomyopathy by regulating calcium homeostasisChao Quan0Qian Du1Min Li2Ruizhen Wang3Qian Ouyang4Shu Su5Sangsang Zhu6Qiaoli Chen7Yang Sheng8Liang Chen9Hong Wang10David G. Campbell11Carol MacKintosh12Zhongzhou Yang13Kunfu Ouyang14Hong Yu Wang15Shuai Chen16State Key Laboratory of Pharmaceutical Biotechnology, Department of Cardiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Model Animal Research Center, Nanjing UniversityState Key Laboratory of Pharmaceutical Biotechnology, Department of Cardiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Model Animal Research Center, Nanjing UniversityState Key Laboratory of Pharmaceutical Biotechnology, Department of Cardiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Model Animal Research Center, Nanjing UniversityState Key Laboratory of Pharmaceutical Biotechnology, Department of Cardiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Model Animal Research Center, Nanjing UniversityMOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing UniversityMOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing UniversityState Key Laboratory of Pharmaceutical Biotechnology, Department of Cardiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Model Animal Research Center, Nanjing UniversityState Key Laboratory of Pharmaceutical Biotechnology, Department of Cardiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Model Animal Research Center, Nanjing UniversityState Key Laboratory of Pharmaceutical Biotechnology, Department of Cardiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Model Animal Research Center, Nanjing UniversityState Key Laboratory of Pharmaceutical Biotechnology, Department of Cardiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Model Animal Research Center, Nanjing UniversityKey Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking UniversityMRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of DundeeDivision of Cell and Developmental Biology, School of Life Sciences, University of DundeeState Key Laboratory of Pharmaceutical Biotechnology, Department of Cardiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Model Animal Research Center, Nanjing UniversityKey Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking UniversityMOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing UniversityState Key Laboratory of Pharmaceutical Biotechnology, Department of Cardiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Model Animal Research Center, Nanjing UniversityMolecular mechanisms linking myocardial insulin resistance to diabetic cardiomyopathy are incompletely understood. Here the authors show that myocardial insulin resistance impairs a PKB-SPEG-SERCA2a signaling axis, which contributes to the development of diabetic cardiomyopathy.https://doi.org/10.1038/s41467-020-16116-9 |
| spellingShingle | Chao Quan Qian Du Min Li Ruizhen Wang Qian Ouyang Shu Su Sangsang Zhu Qiaoli Chen Yang Sheng Liang Chen Hong Wang David G. Campbell Carol MacKintosh Zhongzhou Yang Kunfu Ouyang Hong Yu Wang Shuai Chen A PKB-SPEG signaling nexus links insulin resistance with diabetic cardiomyopathy by regulating calcium homeostasis Nature Communications |
| title | A PKB-SPEG signaling nexus links insulin resistance with diabetic cardiomyopathy by regulating calcium homeostasis |
| title_full | A PKB-SPEG signaling nexus links insulin resistance with diabetic cardiomyopathy by regulating calcium homeostasis |
| title_fullStr | A PKB-SPEG signaling nexus links insulin resistance with diabetic cardiomyopathy by regulating calcium homeostasis |
| title_full_unstemmed | A PKB-SPEG signaling nexus links insulin resistance with diabetic cardiomyopathy by regulating calcium homeostasis |
| title_short | A PKB-SPEG signaling nexus links insulin resistance with diabetic cardiomyopathy by regulating calcium homeostasis |
| title_sort | pkb speg signaling nexus links insulin resistance with diabetic cardiomyopathy by regulating calcium homeostasis |
| url | https://doi.org/10.1038/s41467-020-16116-9 |
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