Experimental Study of Collateral Patency following Overlapped Multilayer Flow Modulators Deployment
Decades after its introduction, endovascular aneurysm repair remains a challenging procedure with risks of collateral patency failure. Here, we investigate the ability of a porous stent, the Multilayer Flow Modulator (MFM), to maintain renal perfusion after a single or overlapping case. Silicone mod...
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| Format: | Article |
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MDPI AG
2022-06-01
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| Series: | Fluids |
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| Online Access: | https://www.mdpi.com/2311-5521/7/7/220 |
| _version_ | 1797406433116946432 |
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| author | Simon Tupin Kei Takase Makoto Ohta |
| author_facet | Simon Tupin Kei Takase Makoto Ohta |
| author_sort | Simon Tupin |
| collection | DOAJ |
| description | Decades after its introduction, endovascular aneurysm repair remains a challenging procedure with risks of collateral patency failure. Here, we investigate the ability of a porous stent, the Multilayer Flow Modulator (MFM), to maintain renal perfusion after a single or overlapping case. Silicone models representing an ideal infrarenal AAA geometry were used to analyze and compare three cases (control, single MFM and two overlapped MFMs). Micro-computed tomography was used to image the deployed MFM devices geometry and evaluate pore size and density along with porosity in both two (planimetric) and three dimensions (gravimetric). Laser particle image velocimetry (PIV) experiments were performed to image velocity and vorticity fields at the aorta-renal bifurcation. Flow experiments revealed renal arteries perfusion preservation in both single and overlapped cases. Microstructure analysis revealed an uneven distribution of wires in the MFM devices leading to local change in planimetric porosity and pore size. Overlap of a second MFM device led to a significant decrease in those 2D metrics but did not affect the gravimetric porosity and the branch perfusion. This first microstructure evaluation of MFM device combined with flow experiments revealed the ability of the device to preserve collateral flow thanks to a highly porous microstructure. |
| first_indexed | 2024-03-09T03:26:23Z |
| format | Article |
| id | doaj.art-5db0afa90947464aa1c62a1c1064bc3e |
| institution | Directory Open Access Journal |
| issn | 2311-5521 |
| language | English |
| last_indexed | 2024-03-09T03:26:23Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Fluids |
| spelling | doaj.art-5db0afa90947464aa1c62a1c1064bc3e2023-12-03T15:02:04ZengMDPI AGFluids2311-55212022-06-017722010.3390/fluids7070220Experimental Study of Collateral Patency following Overlapped Multilayer Flow Modulators DeploymentSimon Tupin0Kei Takase1Makoto Ohta2Biomedical Flow Dynamics Laboratory, Institute of Fluid Science, Tohoku University, Sendai 980-8577, JapanDepartment of Diagnostic Radiology, Tohoku University School of Medicine, Sendai 980-8575, JapanBiomedical Flow Dynamics Laboratory, Institute of Fluid Science, Tohoku University, Sendai 980-8577, JapanDecades after its introduction, endovascular aneurysm repair remains a challenging procedure with risks of collateral patency failure. Here, we investigate the ability of a porous stent, the Multilayer Flow Modulator (MFM), to maintain renal perfusion after a single or overlapping case. Silicone models representing an ideal infrarenal AAA geometry were used to analyze and compare three cases (control, single MFM and two overlapped MFMs). Micro-computed tomography was used to image the deployed MFM devices geometry and evaluate pore size and density along with porosity in both two (planimetric) and three dimensions (gravimetric). Laser particle image velocimetry (PIV) experiments were performed to image velocity and vorticity fields at the aorta-renal bifurcation. Flow experiments revealed renal arteries perfusion preservation in both single and overlapped cases. Microstructure analysis revealed an uneven distribution of wires in the MFM devices leading to local change in planimetric porosity and pore size. Overlap of a second MFM device led to a significant decrease in those 2D metrics but did not affect the gravimetric porosity and the branch perfusion. This first microstructure evaluation of MFM device combined with flow experiments revealed the ability of the device to preserve collateral flow thanks to a highly porous microstructure.https://www.mdpi.com/2311-5521/7/7/220AAAMFMcollateral patencylaser particle imaging velocimetrymicrostructureporosity |
| spellingShingle | Simon Tupin Kei Takase Makoto Ohta Experimental Study of Collateral Patency following Overlapped Multilayer Flow Modulators Deployment Fluids AAA MFM collateral patency laser particle imaging velocimetry microstructure porosity |
| title | Experimental Study of Collateral Patency following Overlapped Multilayer Flow Modulators Deployment |
| title_full | Experimental Study of Collateral Patency following Overlapped Multilayer Flow Modulators Deployment |
| title_fullStr | Experimental Study of Collateral Patency following Overlapped Multilayer Flow Modulators Deployment |
| title_full_unstemmed | Experimental Study of Collateral Patency following Overlapped Multilayer Flow Modulators Deployment |
| title_short | Experimental Study of Collateral Patency following Overlapped Multilayer Flow Modulators Deployment |
| title_sort | experimental study of collateral patency following overlapped multilayer flow modulators deployment |
| topic | AAA MFM collateral patency laser particle imaging velocimetry microstructure porosity |
| url | https://www.mdpi.com/2311-5521/7/7/220 |
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