TCA cycle remodeling drives proinflammatory signaling in humans with pulmonary tuberculosis.

TCA cycle remodeling drives proinflammatory signaling in humans with pulmonary tuberculosis.

The metabolic signaling pathways that drive pathologic tissue inflammation and damage in humans with pulmonary tuberculosis (TB) are not well understood. Using combined methods in plasma high-resolution metabolomics, lipidomics and cytokine profiling from a multicohort study of humans with pulmonary...

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Bibliographic Details
Main Authors: Jeffrey M Collins, Dean P Jones, Ashish Sharma, Manoj Khadka, Ken H Liu, Russell R Kempker, Brendan Prideaux, Kristal Maner-Smith, Nestani Tukvadze, N Sarita Shah, James C M Brust, Rafick-Pierre Sékaly, Neel R Gandhi, Henry M Blumberg, Eric A Ortlund, Thomas R Ziegler
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-09-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1009941

Internet

https://doi.org/10.1371/journal.ppat.1009941

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