Antibiotic-Loaded Gold Nanoparticles: A Nano-Arsenal against ESBL Producer-Resistant Pathogens
The advent of new antibiotics has helped clinicians to control severe bacterial infections. Despite this, inappropriate and redundant use of antibiotics, inadequate diagnosis, and smart resistant mechanisms developed by pathogens sometimes lead to the failure of treatment strategies. The genotypic a...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/15/2/430 |
| _version_ | 1827755919158542336 |
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| author | Syed Mohd Danish Rizvi Amr Selim Abu Lila Afrasim Moin Talib Hussain Mohammad Amjad Kamal Hana Sonbol El-Sayed Khafagy |
| author_facet | Syed Mohd Danish Rizvi Amr Selim Abu Lila Afrasim Moin Talib Hussain Mohammad Amjad Kamal Hana Sonbol El-Sayed Khafagy |
| author_sort | Syed Mohd Danish Rizvi |
| collection | DOAJ |
| description | The advent of new antibiotics has helped clinicians to control severe bacterial infections. Despite this, inappropriate and redundant use of antibiotics, inadequate diagnosis, and smart resistant mechanisms developed by pathogens sometimes lead to the failure of treatment strategies. The genotypic analysis of clinical samples revealed that the rapid spread of extended-spectrum β-lactamases (ESBLs) genes is one of the most common approaches acquired by bacterial pathogens to become resistant. The scenario compelled the researchers to prioritize the design and development of novel and effective therapeutic options. Nanotechnology has emerged as a plausible groundbreaking tool against resistant infectious pathogens. Numerous reports suggested that inorganic nanomaterials, specifically gold nanoparticles (AuNPs), have converted unresponsive antibiotics into potent ones against multi-drug resistant pathogenic strains. Interestingly, after almost two decades of exhaustive preclinical evaluations, AuNPs are gradually progressively moving ahead toward clinical evaluations. However, the mechanistic aspects of the antibacterial action of AuNPs remain an unsolved puzzle for the scientific fraternity. Thus, the review covers state-of-the-art investigations pertaining to the efficacy of AuNPs as a tool to overcome ESBLs acquired resistance, their applicability and toxicity perspectives, and the revelation of the most appropriate proposed mechanism of action. Conclusively, the trend suggested that antibiotic-loaded AuNPs could be developed into a promising interventional strategy to limit and overcome the concerns of antibiotic-resistance. |
| first_indexed | 2024-03-11T08:16:50Z |
| format | Article |
| id | doaj.art-5db494a7adb84dcf972f167da2b6bf6e |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-11T08:16:50Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-5db494a7adb84dcf972f167da2b6bf6e2023-11-16T22:39:51ZengMDPI AGPharmaceutics1999-49232023-01-0115243010.3390/pharmaceutics15020430Antibiotic-Loaded Gold Nanoparticles: A Nano-Arsenal against ESBL Producer-Resistant PathogensSyed Mohd Danish Rizvi0Amr Selim Abu Lila1Afrasim Moin2Talib Hussain3Mohammad Amjad Kamal4Hana Sonbol5El-Sayed Khafagy6Department of Pharmaceutics, College of Pharmacy, University of Ha’il, Ha’il 81442, Saudi ArabiaDepartment of Pharmaceutics, College of Pharmacy, University of Ha’il, Ha’il 81442, Saudi ArabiaDepartment of Pharmaceutics, College of Pharmacy, University of Ha’il, Ha’il 81442, Saudi ArabiaMolecular Diagnostic & Personalized Therapeutic Unit, University of Ha’il, Ha’il 81442, Saudi ArabiaInstitutes for Systems Genetics, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu 610065, ChinaDepartment of Biology, College of Science, Princess Nourah bint Abdulrahman University, Riyadh 11671, Saudi ArabiaDepartment of Pharmaceutics, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-kharj 11942, Saudi ArabiaThe advent of new antibiotics has helped clinicians to control severe bacterial infections. Despite this, inappropriate and redundant use of antibiotics, inadequate diagnosis, and smart resistant mechanisms developed by pathogens sometimes lead to the failure of treatment strategies. The genotypic analysis of clinical samples revealed that the rapid spread of extended-spectrum β-lactamases (ESBLs) genes is one of the most common approaches acquired by bacterial pathogens to become resistant. The scenario compelled the researchers to prioritize the design and development of novel and effective therapeutic options. Nanotechnology has emerged as a plausible groundbreaking tool against resistant infectious pathogens. Numerous reports suggested that inorganic nanomaterials, specifically gold nanoparticles (AuNPs), have converted unresponsive antibiotics into potent ones against multi-drug resistant pathogenic strains. Interestingly, after almost two decades of exhaustive preclinical evaluations, AuNPs are gradually progressively moving ahead toward clinical evaluations. However, the mechanistic aspects of the antibacterial action of AuNPs remain an unsolved puzzle for the scientific fraternity. Thus, the review covers state-of-the-art investigations pertaining to the efficacy of AuNPs as a tool to overcome ESBLs acquired resistance, their applicability and toxicity perspectives, and the revelation of the most appropriate proposed mechanism of action. Conclusively, the trend suggested that antibiotic-loaded AuNPs could be developed into a promising interventional strategy to limit and overcome the concerns of antibiotic-resistance.https://www.mdpi.com/1999-4923/15/2/430antibiotic resistancebacterial pathogensESBLsgold nanoparticlesnano-therapeutics |
| spellingShingle | Syed Mohd Danish Rizvi Amr Selim Abu Lila Afrasim Moin Talib Hussain Mohammad Amjad Kamal Hana Sonbol El-Sayed Khafagy Antibiotic-Loaded Gold Nanoparticles: A Nano-Arsenal against ESBL Producer-Resistant Pathogens Pharmaceutics antibiotic resistance bacterial pathogens ESBLs gold nanoparticles nano-therapeutics |
| title | Antibiotic-Loaded Gold Nanoparticles: A Nano-Arsenal against ESBL Producer-Resistant Pathogens |
| title_full | Antibiotic-Loaded Gold Nanoparticles: A Nano-Arsenal against ESBL Producer-Resistant Pathogens |
| title_fullStr | Antibiotic-Loaded Gold Nanoparticles: A Nano-Arsenal against ESBL Producer-Resistant Pathogens |
| title_full_unstemmed | Antibiotic-Loaded Gold Nanoparticles: A Nano-Arsenal against ESBL Producer-Resistant Pathogens |
| title_short | Antibiotic-Loaded Gold Nanoparticles: A Nano-Arsenal against ESBL Producer-Resistant Pathogens |
| title_sort | antibiotic loaded gold nanoparticles a nano arsenal against esbl producer resistant pathogens |
| topic | antibiotic resistance bacterial pathogens ESBLs gold nanoparticles nano-therapeutics |
| url | https://www.mdpi.com/1999-4923/15/2/430 |
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