Quantitative Analysis of Cenobamate and Concomitant Anti-Seizure Medications in Human Plasma via Ultra-High Performance Liquid Chromatography–Tandem Mass Spectrometry

Quantitative Analysis of Cenobamate and Concomitant Anti-Seizure Medications in Human Plasma via Ultra-High Performance Liquid Chromatography–Tandem Mass Spectrometry

Cenobamate (CNB) is a new anti-seizure medication (ASM) recently introduced in clinical practice after approval by the FDA and EMA for the add-on treatment of focal onset seizures in adult patients. Although its mechanism of action has not been fully understood, CNB showed promising clinical efficac...

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Bibliographic Details
Main Authors: Linda Molteni, Bruno Charlier, Albino Coglianese, Viviana Izzo, Giovanni Assenza, Pierantonio Menna, Ugo de Grazia, Annachiara D’Urso
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:Molecules
Subjects:
cenobamate
anti-seizure medications
therapeutic drug monitoring
pharmacokinetics
UHPLC–MS/MS
Online Access:https://www.mdpi.com/1420-3049/29/4/884

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