Pathological diagnosis of antibody-mediated rejection in renal allograft without c4d staining, how much reliable?
Background: C4d as a part of complement activation process is a marker for detecting antibody-mediated rejection (ABMR) and its positivity accompanied by positive donor specific antibody (DSA), and morphologic view of humoral rejection has been suggested to detect ABMR since 2003. Materials and Me...
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Wolters Kluwer Medknow Publications
2012-01-01
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| Series: | Advanced Biomedical Research |
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| Online Access: | http://www.advbiores.net/article.asp?issn=2277-9175;year=2012;volume=1;issue=1;spage=40;epage=40;aulast=Taheri |
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| author | Diana Taheri Ardeshir Talebi Maryam Taghaodi Mehdi Fesharakizadeh Mojgan Mortazavi Afshin Azhir Shahaboddin Dolatkhah Noushin A Moghaddam Mohsen Nasr |
| author_facet | Diana Taheri Ardeshir Talebi Maryam Taghaodi Mehdi Fesharakizadeh Mojgan Mortazavi Afshin Azhir Shahaboddin Dolatkhah Noushin A Moghaddam Mohsen Nasr |
| author_sort | Diana Taheri |
| collection | DOAJ |
| description | Background: C4d as a part of complement activation process is a marker for detecting antibody-mediated rejection (ABMR) and its positivity accompanied by positive donor specific antibody (DSA), and morphologic view of humoral rejection has been suggested to detect ABMR since 2003.
Materials and Methods: 41 specimens of transplanted kidney biopsies gathered from 2006 to 2008 were evaluated for morphological changes on light microscopy, and nephro-pathologist made distinct diagnosis for all of specimens then c4d staining was done for all of them. The association between primary diagnosis without c4d staining and c4d scoring on peritubular capillaries and glomerular capillaries were evaluated to determine whether morphological changes were enough for distinct diagnosis or not.
Results: Acute tubular necrosis (ATN) 27%, interstitial fibrosis and tubular atrophy (IF&TA) 17%, and T cell mediated rejection (TCMR) 22% were the commonest diagnosis on light microscopy, and 17% of all biopsies had diffuse positive c4d staining. There was not any report of ABMR in morphological evaluation while c4d positive staining was seen in some specimens (17%). It may result from masking of ABMR by other morphological changes such as TCMR and no specific histologic changes for ABMR on light microscopy.
Conclusion: We would like to emphasize that c4d staining should be done for all of renal allograft biopsies, and pathologists all over the world should consider the probability of ABMR masked by other morphological changes on light microscopic evaluation. |
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| issn | 2277-9175 2277-9175 |
| language | English |
| last_indexed | 2024-12-13T14:13:05Z |
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| series | Advanced Biomedical Research |
| spelling | doaj.art-5db94ff1674a443e877bfe085e78c3a12022-12-21T23:42:23ZengWolters Kluwer Medknow PublicationsAdvanced Biomedical Research2277-91752277-91752012-01-0111404010.4103/2277-9175.100139Pathological diagnosis of antibody-mediated rejection in renal allograft without c4d staining, how much reliable?Diana TaheriArdeshir TalebiMaryam TaghaodiMehdi FesharakizadehMojgan MortazaviAfshin AzhirShahaboddin DolatkhahNoushin A MoghaddamMohsen NasrBackground: C4d as a part of complement activation process is a marker for detecting antibody-mediated rejection (ABMR) and its positivity accompanied by positive donor specific antibody (DSA), and morphologic view of humoral rejection has been suggested to detect ABMR since 2003. Materials and Methods: 41 specimens of transplanted kidney biopsies gathered from 2006 to 2008 were evaluated for morphological changes on light microscopy, and nephro-pathologist made distinct diagnosis for all of specimens then c4d staining was done for all of them. The association between primary diagnosis without c4d staining and c4d scoring on peritubular capillaries and glomerular capillaries were evaluated to determine whether morphological changes were enough for distinct diagnosis or not. Results: Acute tubular necrosis (ATN) 27%, interstitial fibrosis and tubular atrophy (IF&TA) 17%, and T cell mediated rejection (TCMR) 22% were the commonest diagnosis on light microscopy, and 17% of all biopsies had diffuse positive c4d staining. There was not any report of ABMR in morphological evaluation while c4d positive staining was seen in some specimens (17%). It may result from masking of ABMR by other morphological changes such as TCMR and no specific histologic changes for ABMR on light microscopy. Conclusion: We would like to emphasize that c4d staining should be done for all of renal allograft biopsies, and pathologists all over the world should consider the probability of ABMR masked by other morphological changes on light microscopic evaluation.http://www.advbiores.net/article.asp?issn=2277-9175;year=2012;volume=1;issue=1;spage=40;epage=40;aulast=TaheriAntibody-mediated rejectionc4dkidney transplantation |
| spellingShingle | Diana Taheri Ardeshir Talebi Maryam Taghaodi Mehdi Fesharakizadeh Mojgan Mortazavi Afshin Azhir Shahaboddin Dolatkhah Noushin A Moghaddam Mohsen Nasr Pathological diagnosis of antibody-mediated rejection in renal allograft without c4d staining, how much reliable? Advanced Biomedical Research Antibody-mediated rejection c4d kidney transplantation |
| title | Pathological diagnosis of antibody-mediated rejection in renal allograft without c4d staining, how much reliable? |
| title_full | Pathological diagnosis of antibody-mediated rejection in renal allograft without c4d staining, how much reliable? |
| title_fullStr | Pathological diagnosis of antibody-mediated rejection in renal allograft without c4d staining, how much reliable? |
| title_full_unstemmed | Pathological diagnosis of antibody-mediated rejection in renal allograft without c4d staining, how much reliable? |
| title_short | Pathological diagnosis of antibody-mediated rejection in renal allograft without c4d staining, how much reliable? |
| title_sort | pathological diagnosis of antibody mediated rejection in renal allograft without c4d staining how much reliable |
| topic | Antibody-mediated rejection c4d kidney transplantation |
| url | http://www.advbiores.net/article.asp?issn=2277-9175;year=2012;volume=1;issue=1;spage=40;epage=40;aulast=Taheri |
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