Evaluation of the levels of cardiac troponin I as an end point in resuscitation of dogs with hemorrhagic shock
This study sought to assess the levels of cardiac troponin I, as a resuscitation end point, along with oxygen delivery (DO2) and oxygen consumption (VO2) during resuscitation of dogs with experimental hemorrhagic shock using lactated Ringer’s solution or 6% hydroxyethyl starch. After induction of an...
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| Format: | Article |
| Language: | English |
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Ferdowsi University of Mashhad
2018-03-01
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| Series: | The Iranian Journal of Veterinary Science and Technology |
| Subjects: | |
| Online Access: | https://ijvst.um.ac.ir/article_29809_bd74f8e9b997dd068848e8f2ddaf268c.pdf |
| _version_ | 1828407967740854272 |
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| author | Reza Azargoun Reza Avizeh Alireza Ghadiri Hadi Imani Rastabi Mahdi Pourmahdi Boroujeni Mohammad Razi Jalali |
| author_facet | Reza Azargoun Reza Avizeh Alireza Ghadiri Hadi Imani Rastabi Mahdi Pourmahdi Boroujeni Mohammad Razi Jalali |
| author_sort | Reza Azargoun |
| collection | DOAJ |
| description | This study sought to assess the levels of cardiac troponin I, as a resuscitation end point, along with oxygen delivery (DO2) and oxygen consumption (VO2) during resuscitation of dogs with experimental hemorrhagic shock using lactated Ringer’s solution or 6% hydroxyethyl starch. After induction of anesthesia (control measurements), hemorrhagic shock was induced by rapid removal of blood to achieve a mean arterial pressure (MAP) of 40 to 50 mmHg within 30 minutes and then maintained in hypovolemic situation for additional 30 minutes (second and third stages of measurements). Afterward, the dogs were randomly assigned to two groups which received 20 ml/kg lactated Ringer’s solution or 5 ml/kg Hydroxyethyl starch, in four consecutive 15 minutes intervals (forth stage of measurements). One hour after the last resuscitation step, final measurements were performed. Hemorrhagic shock caused marked elevation in the levels of cTnI and reduction in DO2 and VO2 (p < 0.05). Following resuscitation, a significant reduction was observed in the levels of cTnI and VO2 but a significant elevation was seen in DO2 levels (p < 0.05), without significant differences between the groups (p > 0.05). The results of this study proved that cTnI can be evaluated for better monitoring during fluid therapy in hemorrhagic shock, as a novel resuscitation end point. |
| first_indexed | 2024-12-10T11:31:44Z |
| format | Article |
| id | doaj.art-5dbb568c15544eb29136c5cf81ad31c7 |
| institution | Directory Open Access Journal |
| issn | 2008-465X 2423-6306 |
| language | English |
| last_indexed | 2024-12-10T11:31:44Z |
| publishDate | 2018-03-01 |
| publisher | Ferdowsi University of Mashhad |
| record_format | Article |
| series | The Iranian Journal of Veterinary Science and Technology |
| spelling | doaj.art-5dbb568c15544eb29136c5cf81ad31c72022-12-22T01:50:33ZengFerdowsi University of MashhadThe Iranian Journal of Veterinary Science and Technology2008-465X2423-63062018-03-01102374210.22067/veterinary.v2i10.7388229809Evaluation of the levels of cardiac troponin I as an end point in resuscitation of dogs with hemorrhagic shockReza Azargoun0Reza Avizeh1Alireza Ghadiri2Hadi Imani Rastabi3Mahdi Pourmahdi Boroujeni4Mohammad Razi Jalali5shahid chamran universityShahid Chamran universityshahid chamran universityshahid chamran universityshahid chamran universityshahid chamran universityThis study sought to assess the levels of cardiac troponin I, as a resuscitation end point, along with oxygen delivery (DO2) and oxygen consumption (VO2) during resuscitation of dogs with experimental hemorrhagic shock using lactated Ringer’s solution or 6% hydroxyethyl starch. After induction of anesthesia (control measurements), hemorrhagic shock was induced by rapid removal of blood to achieve a mean arterial pressure (MAP) of 40 to 50 mmHg within 30 minutes and then maintained in hypovolemic situation for additional 30 minutes (second and third stages of measurements). Afterward, the dogs were randomly assigned to two groups which received 20 ml/kg lactated Ringer’s solution or 5 ml/kg Hydroxyethyl starch, in four consecutive 15 minutes intervals (forth stage of measurements). One hour after the last resuscitation step, final measurements were performed. Hemorrhagic shock caused marked elevation in the levels of cTnI and reduction in DO2 and VO2 (p < 0.05). Following resuscitation, a significant reduction was observed in the levels of cTnI and VO2 but a significant elevation was seen in DO2 levels (p < 0.05), without significant differences between the groups (p > 0.05). The results of this study proved that cTnI can be evaluated for better monitoring during fluid therapy in hemorrhagic shock, as a novel resuscitation end point.https://ijvst.um.ac.ir/article_29809_bd74f8e9b997dd068848e8f2ddaf268c.pdfcardiac troponin idoghemorrhagic shock |
| spellingShingle | Reza Azargoun Reza Avizeh Alireza Ghadiri Hadi Imani Rastabi Mahdi Pourmahdi Boroujeni Mohammad Razi Jalali Evaluation of the levels of cardiac troponin I as an end point in resuscitation of dogs with hemorrhagic shock The Iranian Journal of Veterinary Science and Technology cardiac troponin i dog hemorrhagic shock |
| title | Evaluation of the levels of cardiac troponin I as an end point in resuscitation of dogs with hemorrhagic shock |
| title_full | Evaluation of the levels of cardiac troponin I as an end point in resuscitation of dogs with hemorrhagic shock |
| title_fullStr | Evaluation of the levels of cardiac troponin I as an end point in resuscitation of dogs with hemorrhagic shock |
| title_full_unstemmed | Evaluation of the levels of cardiac troponin I as an end point in resuscitation of dogs with hemorrhagic shock |
| title_short | Evaluation of the levels of cardiac troponin I as an end point in resuscitation of dogs with hemorrhagic shock |
| title_sort | evaluation of the levels of cardiac troponin i as an end point in resuscitation of dogs with hemorrhagic shock |
| topic | cardiac troponin i dog hemorrhagic shock |
| url | https://ijvst.um.ac.ir/article_29809_bd74f8e9b997dd068848e8f2ddaf268c.pdf |
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