Biomimetic Nanozymes Suppressed Ferroptosis to Ameliorate Doxorubicin-Induced Cardiotoxicity via Synergetic Effect of Antioxidant Stress and GPX4 Restoration

Biomimetic Nanozymes Suppressed Ferroptosis to Ameliorate Doxorubicin-Induced Cardiotoxicity via Synergetic Effect of Antioxidant Stress and GPX4 Restoration

Mitochondria-dependent ferroptosis plays an important role in the pathogenesis of doxorubicin (DOX)-induced cardiotoxicity (DIC), which remains a clinical challenge due to the lack of effective interventions. Cerium oxide (CeO<sub>2</sub>), a representative nanozyme, has attracted much a...

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Bibliographic Details
Main Authors: Yunpeng Zhang, Shuang Liu, Jing Peng, Shifeng Cheng, Qingling Zhang, Nan Zhang, Zandong Zhou, Yue Zhang, Yang Zhao, Tong Liu
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Nutrients
Subjects:
doxorubicin-induced cardiomyopathy
ferroptosis
mitochondria
nanozyme
oxidative stress
biomineralization
Online Access:https://www.mdpi.com/2072-6643/15/5/1090

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