Biomimetic carbon nanotubes for neurological disease therapeutics as inherent medication
Nowadays, nanotechnology is revolutionizing the approaches to different fields from manufacture to health. Carbon nanotubes (CNTs) as promising candidates in nanomedicine have great potentials in developing novel entities for central nervous system pathologies, due to their excellent physicochemical...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2020-02-01
|
| Series: | Acta Pharmaceutica Sinica B |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211383519306069 |
| _version_ | 1828756590493171712 |
|---|---|
| author | Chenyang Xiang Yuxuan Zhang Weisheng Guo Xing-Jie Liang |
| author_facet | Chenyang Xiang Yuxuan Zhang Weisheng Guo Xing-Jie Liang |
| author_sort | Chenyang Xiang |
| collection | DOAJ |
| description | Nowadays, nanotechnology is revolutionizing the approaches to different fields from manufacture to health. Carbon nanotubes (CNTs) as promising candidates in nanomedicine have great potentials in developing novel entities for central nervous system pathologies, due to their excellent physicochemical properties and ability to interface with neurons and neuronal circuits. However, most of the studies mainly focused on the drug delivery and bioimaging applications of CNTs, while neglect their application prospects as therapeutic drugs themselves. At present, the relevant reviews are not available yet. Herein we summarized the latest advances on the biomedical and therapeutic applications of CNTs in vitro and in vivo for neurological diseases treatments as inherent therapeutic drugs. The biological mechanisms of CNTs-mediated bio-medical effects and potential toxicity of CNTs were also intensely discussed. It is expected that CNTs will exploit further neurological applications on disease therapy in the near future. Key words: Carbon nanotubes, Nervous system diseases, Drug delivery, Therapeutic drug, Inherent medication, Toxicity |
| first_indexed | 2024-12-10T23:18:53Z |
| format | Article |
| id | doaj.art-5dbcef5b03344b69b3e0dab3ef6934c3 |
| institution | Directory Open Access Journal |
| issn | 2211-3835 |
| language | English |
| last_indexed | 2024-12-10T23:18:53Z |
| publishDate | 2020-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Acta Pharmaceutica Sinica B |
| spelling | doaj.art-5dbcef5b03344b69b3e0dab3ef6934c32022-12-22T01:29:46ZengElsevierActa Pharmaceutica Sinica B2211-38352020-02-01102239248Biomimetic carbon nanotubes for neurological disease therapeutics as inherent medicationChenyang Xiang0Yuxuan Zhang1Weisheng Guo2Xing-Jie Liang3Translational Medicine Center, Key Laboratory of Molecular Target & Clinical Pharmacology and the State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences & the Second Affiliated Hospital, Guangzhou Medical University, Guangzhou 510260, ChinaCAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing 100190, ChinaTranslational Medicine Center, Key Laboratory of Molecular Target & Clinical Pharmacology and the State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences & the Second Affiliated Hospital, Guangzhou Medical University, Guangzhou 510260, China; Corresponding authors.Translational Medicine Center, Key Laboratory of Molecular Target & Clinical Pharmacology and the State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences & the Second Affiliated Hospital, Guangzhou Medical University, Guangzhou 510260, China; CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing 100190, China; Corresponding authors.Nowadays, nanotechnology is revolutionizing the approaches to different fields from manufacture to health. Carbon nanotubes (CNTs) as promising candidates in nanomedicine have great potentials in developing novel entities for central nervous system pathologies, due to their excellent physicochemical properties and ability to interface with neurons and neuronal circuits. However, most of the studies mainly focused on the drug delivery and bioimaging applications of CNTs, while neglect their application prospects as therapeutic drugs themselves. At present, the relevant reviews are not available yet. Herein we summarized the latest advances on the biomedical and therapeutic applications of CNTs in vitro and in vivo for neurological diseases treatments as inherent therapeutic drugs. The biological mechanisms of CNTs-mediated bio-medical effects and potential toxicity of CNTs were also intensely discussed. It is expected that CNTs will exploit further neurological applications on disease therapy in the near future. Key words: Carbon nanotubes, Nervous system diseases, Drug delivery, Therapeutic drug, Inherent medication, Toxicityhttp://www.sciencedirect.com/science/article/pii/S2211383519306069 |
| spellingShingle | Chenyang Xiang Yuxuan Zhang Weisheng Guo Xing-Jie Liang Biomimetic carbon nanotubes for neurological disease therapeutics as inherent medication Acta Pharmaceutica Sinica B |
| title | Biomimetic carbon nanotubes for neurological disease therapeutics as inherent medication |
| title_full | Biomimetic carbon nanotubes for neurological disease therapeutics as inherent medication |
| title_fullStr | Biomimetic carbon nanotubes for neurological disease therapeutics as inherent medication |
| title_full_unstemmed | Biomimetic carbon nanotubes for neurological disease therapeutics as inherent medication |
| title_short | Biomimetic carbon nanotubes for neurological disease therapeutics as inherent medication |
| title_sort | biomimetic carbon nanotubes for neurological disease therapeutics as inherent medication |
| url | http://www.sciencedirect.com/science/article/pii/S2211383519306069 |
| work_keys_str_mv | AT chenyangxiang biomimeticcarbonnanotubesforneurologicaldiseasetherapeuticsasinherentmedication AT yuxuanzhang biomimeticcarbonnanotubesforneurologicaldiseasetherapeuticsasinherentmedication AT weishengguo biomimeticcarbonnanotubesforneurologicaldiseasetherapeuticsasinherentmedication AT xingjieliang biomimeticcarbonnanotubesforneurologicaldiseasetherapeuticsasinherentmedication |